{"id":"https://openalex.org/W1664563740","doi":"https://doi.org/10.1016/s0079-6123(08)61209-1","title":"Chapter 13 Enantioselective recognition of two anticonvulsants, FCE 26743 and FCE 28073, by MAO, and relationship between MAO-B inhibition and FCE 26743 concentrations in rat brain","display_name":"Chapter 13 Enantioselective recognition of two anticonvulsants, FCE 26743 and FCE 28073, by MAO, and relationship between MAO-B inhibition and FCE 26743 concentrations in rat brain","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W1664563740","doi":"https://doi.org/10.1016/s0079-6123(08)61209-1","mag":"1664563740","pmid":"https://pubmed.ncbi.nlm.nih.gov/8584648"},"language":"en","primary_location":{"id":"doi:10.1016/s0079-6123(08)61209-1","doi":"https://doi.org/10.1016/s0079-6123(08)61209-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0079-6123(08)61209-1","pdf_url":null,"source":{"id":"https://openalex.org/S170217976","display_name":"Progress in brain research","issn_l":"0079-6123","issn":["0079-6123","1875-7855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Brain Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W570818295","display_name":"Current Neurochemical and Pharmacological Aspects of Biogenic Amines - Their Function, Oxidative Deamination and Inhibition"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003140724","display_name":"Margherita Strolin Benedetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Strolin Benedetti","raw_affiliation_strings":["Pharmacia, Nerviano, Milan, Italy","Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Nerviano, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015361221","display_name":"Paola Tocchetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Tocchetti","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Rocchetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Rocchetti","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063907460","display_name":"Marcella Martignoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Martignoni","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013120459","display_name":"P. Marrari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Marrari","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021392198","display_name":"Italo Poggesi","orcid":"https://orcid.org/0000-0003-3079-6954","observed_orcids":["https://orcid.org/0000-0003-3079-6954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Poggesi","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010091677","display_name":"P. Dostert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Dostert","raw_affiliation_strings":["Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacia, Via per Pogliano, 20014 Nerviano, Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6457,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.74107143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"106","issue":null,"first_page":"123","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-recognition","display_name":"chiral recognition","score":0.7820000052452087},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibition","display_name":"monoamine oxidase inhibition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/monoamine-oxidase-b","display_name":"monoamine oxidase B","score":0.9049999713897705},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8949999809265137},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.6970000267028809},{"id":"https://openalex.org/keywords/oxidative-drug-metabolism","display_name":"oxidative drug metabolism","score":0.6990000009536743},{"id":"https://openalex.org/keywords/skf-525a","display_name":"SKF 525-A","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.9039999842643738},{"id":"https://openalex.org/keywords/brain-drug-concentration","display_name":"brain drug concentration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/alanine-derivatives","display_name":"alanine derivatives","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.6273139715194702},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6250803470611572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6117002964019775},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.593605101108551},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5932394862174988},{"id":"https://openalex.org/C114461151","wikidata":"https://www.wikidata.org/wiki/Q14888415","display_name":"Monoamine oxidase A","level":4,"score":0.5685697197914124},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.5114232897758484},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.451265811920166},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44615769386291504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3367518186569214},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32538658380508423},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.25684255361557007},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25395387411117554},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19130641222000122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14790639281272888},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07409095764160156},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0079-6123(08)61209-1","doi":"https://doi.org/10.1016/s0079-6123(08)61209-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0079-6123(08)61209-1","pdf_url":null,"source":{"id":"https://openalex.org/S170217976","display_name":"Progress in brain research","issn_l":"0079-6123","issn":["0079-6123","1875-7855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Brain Research","raw_type":"book-chapter"},{"id":"pmid:8584648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8584648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W69154181","https://openalex.org/W182320622","https://openalex.org/W1546157867","https://openalex.org/W1964486233","https://openalex.org/W1976870178","https://openalex.org/W1979955365","https://openalex.org/W1991414578","https://openalex.org/W1997364324","https://openalex.org/W1999688453","https://openalex.org/W2011580074","https://openalex.org/W2016301461","https://openalex.org/W2025365229","https://openalex.org/W2036487197","https://openalex.org/W2039641498","https://openalex.org/W2051654271","https://openalex.org/W2066186029","https://openalex.org/W2068676996","https://openalex.org/W2070059653","https://openalex.org/W2070806978","https://openalex.org/W2078865702","https://openalex.org/W2080631706","https://openalex.org/W2080914836","https://openalex.org/W2092551867","https://openalex.org/W2107283311","https://openalex.org/W2128881722","https://openalex.org/W2169077209","https://openalex.org/W2239904743","https://openalex.org/W2324227497","https://openalex.org/W2401973332","https://openalex.org/W2499702265","https://openalex.org/W6607313087"],"related_works":["https://openalex.org/W2973395064","https://openalex.org/W6967623364","https://openalex.org/W2977061669","https://openalex.org/W2975783006","https://openalex.org/W2386008356","https://openalex.org/W2137685501","https://openalex.org/W2136833466","https://openalex.org/W7099964136","https://openalex.org/W2395805515","https://openalex.org/W1987977977"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}