{"id":"https://openalex.org/W166375989","doi":null,"title":"Melperone in the treatment of iatrogenic psychosis in Parkinson's disease.","display_name":"Melperone in the treatment of iatrogenic psychosis in Parkinson's disease.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W166375989","mag":"166375989","pmid":"https://pubmed.ncbi.nlm.nih.gov/8934152"},"language":"en","primary_location":{"id":"pmid:8934152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8934152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Functional neurology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L Barbato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Barbato","raw_affiliation_strings":["Istituto Antonio Benedetti, Vicenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Antonio Benedetti, Vicenza, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Monge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Monge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031345514","display_name":"Fabrizio Stocchi","orcid":"https://orcid.org/0000-0002-5763-0033","observed_orcids":["https://orcid.org/0000-0002-5763-0033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Stocchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109122452","display_name":"G.P. Nordera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Nordera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2787,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.53213575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"201","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melperone","display_name":"melperone","score":1.0},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9330000281333923},{"id":"https://openalex.org/keywords/levodopa-withdrawal","display_name":"levodopa withdrawal","score":0.8830000162124634},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.7620000243186951},{"id":"https://openalex.org/keywords/unified-parkinson-s-disease-rating-scale","display_name":"Unified Parkinson's Disease Rating Scale","score":0.7929999828338623},{"id":"https://openalex.org/keywords/brief-psychiatric-rating-scale","display_name":"Brief Psychiatric Rating Scale","score":0.9330000281333923},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7585822343826294},{"id":"https://openalex.org/C2778528637","wikidata":"https://www.wikidata.org/wiki/Q4967025","display_name":"Brief Psychiatric Rating Scale","level":3,"score":0.750534176826477},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.667911946773529},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.606650710105896},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.5690662860870361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5587166547775269},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5424602031707764},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.48846474289894104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47380417585372925},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.4454454481601715},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43970412015914917},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3628104627132416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28392601013183594},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.19102096557617188},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002090","descriptor_name":"Butyrophenones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002090","descriptor_name":"Butyrophenones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011605","descriptor_name":"Psychoses, Substance-Induced","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011605","descriptor_name":"Psychoses, Substance-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8934152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8934152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Functional neurology","raw_type":"Journal Article"},{"id":"mag:166375989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8934152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2137007688","https://openalex.org/W2063876295","https://openalex.org/W2048145705","https://openalex.org/W2326981815","https://openalex.org/W2729759407","https://openalex.org/W1977556495","https://openalex.org/W2554393705","https://openalex.org/W2581655053","https://openalex.org/W1971439299","https://openalex.org/W2333444689"],"abstract_inverted_index":{"The":[0,17,146],"pharmacological":[1],"management":[2,79],"of":[3,21,32,75,80,108,127,137,196],"Parkinson's":[4,111],"disease":[5],"(PD)":[6],"can":[7],"be":[8,209],"complicated":[9],"by":[10,14],"psychiatric":[11,132],"disorders":[12],"induced":[13],"antiparkinsonian":[15],"drugs.":[16],"reduction":[18],"or":[19],"withdrawal":[20],"levodopa":[22],"(l-dopa)":[23],"and":[24,42,72,99,171],"other":[25],"drugs":[26],"commonly":[27],"used":[28],"in":[29,51,77,83,96,100,118,174,201],"the":[30,36,58,61,69,73,78,97,101,105,109,124,134,138,202],"treatment":[31],"PD":[33],"may":[34],"attenuate":[35],"psychosis":[37,82],"but":[38,200],"exacerbate":[39],"motor":[40,106,169],"impairment":[41],"disability.":[43],"Melperone":[44],"is":[45],"an":[46],"atypical":[47],"antipsychotic":[48],"drug":[49],"showing":[50],"vivo":[52],"a":[53],"greater":[54],"relative":[55],"affinity":[56],"for":[57],"5-HT2":[59],"than":[60],"D2":[62],"receptors.":[63],"A":[64],"two-year":[65],"study":[66],"to":[67,208],"assess":[68,131],"clinical":[70],"efficacy":[71],"safety":[74],"melperone":[76,206],"iatrogenic":[81],"30":[84],"parkinsonian":[85],"patients":[86,95,192,205],"was":[87,92,121,144,150],"carried":[88],"out.":[89],"Neurological":[90],"evaluation":[91],"performed":[93],"with":[94,156,188],"\"off\"":[98],"\"on\"":[102,119,175],"state":[103,120,176],"using":[104,123],"examination":[107],"Unified":[110],"Disease":[112],"Rating":[113,141],"Scale":[114,142],"(UPDRS).":[115],"Time":[116],"spent":[117,173],"evaluated":[122],"self-evaluation":[125],"diary":[126],"daily":[128,178],"life.":[129],"To":[130],"disturbances":[133],"modified":[135],"version":[136],"Brief":[139],"Psychiatric":[140],"(BPRS)":[143],"used.":[145],"mean":[147],"BPRS":[148],"score":[149,170],"significantly":[151],"reduced":[152],"when":[153,185],"comparing":[154,186],"baseline":[155,187],"individual":[157],"examinations;":[158],"no":[159,181],"statistically":[160,182],"significant":[161,183],"differences":[162,184],"were":[163],"found":[164],"between":[165],"subsequent":[166,189],"examinations.":[167,190],"UPDRS":[168],"time":[172],"during":[177],"life":[179],"showed":[180],"Two":[191],"dropped":[193],"out":[194],"because":[195],"excessive":[197],"sedation":[198],"problems":[199],"remaining":[203],"28":[204],"proved":[207],"optimally":[210],"tolerated.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
