{"id":"https://openalex.org/W1663318878","doi":"https://doi.org/10.1016/s0021-9258(19)45804-3","title":"Deoxyadenosine Diphosphate as a Substrate and Inhibitor of Polynucleotide Phosphorylase of Micrococcus luteus","display_name":"Deoxyadenosine Diphosphate as a Substrate and Inhibitor of Polynucleotide Phosphorylase of Micrococcus luteus","publication_year":1971,"publication_date":"1971-12-01","ids":{"openalex":"https://openalex.org/W1663318878","doi":"https://doi.org/10.1016/s0021-9258(19)45804-3","mag":"1663318878","pmid":"https://pubmed.ncbi.nlm.nih.gov/5316337"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)45804-3","doi":"https://doi.org/10.1016/s0021-9258(19)45804-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45804-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)45804-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033006726","display_name":"JANICE YANG CHOU","orcid":"https://orcid.org/0000-0003-4004-6516","observed_orcids":["https://orcid.org/0000-0003-4004-6516"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janice Yang Chou","raw_affiliation_strings":["From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006407155","display_name":"Maxine Singer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxine F. Singer","raw_affiliation_strings":["From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9874,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70799794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"246","issue":"24","first_page":"7497","last_page":"7504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polynucleotide-phosphorylase","display_name":"polynucleotide phosphorylase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/micrococcus-luteus","display_name":"Micrococcus luteus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7319999933242798},{"id":"https://openalex.org/keywords/primers","display_name":"primer sequences","score":0.8709999918937683},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.47999998927116394},{"id":"https://openalex.org/keywords/manganese","display_name":"manganese","score":0.9940000176429749},{"id":"https://openalex.org/keywords/initiation-sites","display_name":"initiation sites","score":0.7139999866485596},{"id":"https://openalex.org/keywords/binding-constant","display_name":"binding constant","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2776683811","wikidata":"https://www.wikidata.org/wiki/Q142000","display_name":"Micrococcus luteus","level":4,"score":0.9196789860725403},{"id":"https://openalex.org/C2779478826","wikidata":"https://www.wikidata.org/wiki/Q24780839","display_name":"Polynucleotide phosphorylase","level":5,"score":0.7989164590835571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6471057534217834},{"id":"https://openalex.org/C2780636463","wikidata":"https://www.wikidata.org/wiki/Q422457","display_name":"Deoxyadenosine","level":3,"score":0.5470933318138123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5248779654502869},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4561336636543274},{"id":"https://openalex.org/C2781291461","wikidata":"https://www.wikidata.org/wiki/Q1954952","display_name":"Micrococcus","level":3,"score":0.43932589888572693},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3798309564590454},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30985701084136963},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2719007134437561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26597467064857483},{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.25428611040115356},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1939087212085724},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.11051538586616516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10844928026199341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008837","descriptor_name":"Micrococcus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008837","descriptor_name":"Micrococcus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008837","descriptor_name":"Micrococcus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011119","descriptor_name":"Polynucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011119","descriptor_name":"Polynucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011119","descriptor_name":"Polynucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)45804-3","doi":"https://doi.org/10.1016/s0021-9258(19)45804-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45804-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:5316337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5316337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)45804-3","doi":"https://doi.org/10.1016/s0021-9258(19)45804-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)45804-3","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W73321846","https://openalex.org/W258163986","https://openalex.org/W1499096332","https://openalex.org/W1507811951","https://openalex.org/W1515606077","https://openalex.org/W1516702023","https://openalex.org/W1530654936","https://openalex.org/W1530889893","https://openalex.org/W1538926214","https://openalex.org/W1578530920","https://openalex.org/W1668590966","https://openalex.org/W1832598496","https://openalex.org/W1980227005","https://openalex.org/W1985836092","https://openalex.org/W2007373868","https://openalex.org/W2022302833","https://openalex.org/W2043548667","https://openalex.org/W2050331053","https://openalex.org/W2050678001","https://openalex.org/W2051665075","https://openalex.org/W2052448004","https://openalex.org/W2052480640","https://openalex.org/W2329418110","https://openalex.org/W2412171015"],"related_works":["https://openalex.org/W1482182747","https://openalex.org/W2613682111","https://openalex.org/W2241413189","https://openalex.org/W1578530920","https://openalex.org/W2066453609","https://openalex.org/W1540525217","https://openalex.org/W3005341373","https://openalex.org/W2076193455","https://openalex.org/W2036957844","https://openalex.org/W1530889893"],"abstract_inverted_index":{"Abstract":[0],"dADP":[1,24,98,109,136],"inhibits":[2,111],"de":[3,51],"novo":[4,52],"polymerization":[5,44,53],"of":[6,23,27,39,45,60,64,77,94,123,129],"ADP":[7,32,46],"by":[8,90,114],"polynucleotide":[9],"phosphorylase":[10],"(primer-independent,":[11],"Form":[12,16],"I,":[13],"and":[14,133,137],"primer-dependent,":[15],"T,":[17],"enzyme).":[18],"Inhibition":[19],"occurs":[20],"at":[21,47,74,118],"concentrations":[22,59,76],"2":[25],"orders":[26],"magnitude":[28],"lower":[29],"than":[30],"the":[31,62,84,92,95,124],"concentration.":[33],"Adenosine":[34],"methylene":[35,139],"diphosphonate,":[36],"another":[37],"analogue":[38],"ADP,":[40],"does":[41],"not":[42],"inhibit":[43],"comparable":[48],"concentrations.":[49],"Although":[50],"is":[54,71,88,99],"very":[55],"sensitive":[56],"to":[57,68,82,97,106],"low":[58],"dADP,":[61],"addition":[63],"nucleoside":[65],"monophosphate":[66],"units":[67],"oligonucleotide":[69],"primers":[70],"only":[72],"inhibited":[73],"high":[75],"dADP.":[78],"Thus":[79],"oligonucleotides":[80],"appear":[81],"relieve":[83],"inhibition.":[85],"When":[86],"Mg2+":[87,132],"replaced":[89],"Mn2+,":[91],"sensitivity":[93],"enzyme":[96,117],"markedly":[100],"reduced.":[101],"These":[102],"results":[103],"are":[104,141],"interpreted":[105],"indicate":[107],"that":[108],"specifically":[110],"chain":[112],"initiation":[120],"interaction":[115],"with":[116,135],"an":[119],"site.":[121],"Values":[122],"association":[125],"constants":[126],"for":[127],"formation":[128],"complexes":[130],"between":[131],"Mn2+":[134],"adenosine":[138],"diphosphonate":[140],"presented.":[142]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
