{"id":"https://openalex.org/W1663049697","doi":null,"title":"Origem e Desenvolvimento da Mielina no Sistema Nervoso Central - Um Estudo de Revis\u00e3o","display_name":"Origem e Desenvolvimento da Mielina no Sistema Nervoso Central - Um Estudo de Revis\u00e3o","publication_year":2011,"publication_date":"2011-02-03","ids":{"openalex":"https://openalex.org/W1663049697","mag":"1663049697"},"language":"pt","primary_location":{"id":"pmh:oai:periodicos.unicesumar.edu.br:article/1654","doi":null,"is_oa":true,"landing_page_url":"https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1654","pdf_url":null,"source":{"id":"https://openalex.org/S2738224174","display_name":"Sa\u00fade e Pesquisa","issn_l":"1983-1870","issn":["1983-1870","2176-9206"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312112","host_organization_name":"Universidade Cesumar","host_organization_lineage":["https://openalex.org/P4310312112"],"host_organization_lineage_names":["Universidade Cesumar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2176-9206","raw_type":"Revis\u00e3o de literatura"},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1654","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005975532","display_name":"Priscilla Balestrin Mendes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mendes, Priscilla Balestrin","raw_affiliation_strings":["Universidade Estadual de Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013876351","display_name":"Silvana Regina de Melo","orcid":"https://orcid.org/0000-0003-0968-4376","observed_orcids":["https://orcid.org/0000-0003-0968-4376"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Melo, Silvana Regina de","raw_affiliation_strings":["Universidade Estadual de Maring\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Maring\u00e1","institution_ids":["https://openalex.org/I123443094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123443094"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.8399999737739563},{"id":"https://openalex.org/keywords/myelin-sheath","display_name":"myelin sheath","score":0.9100000262260437},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.8939999938011169},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.9290000200271606},{"id":"https://openalex.org/keywords/axons","display_name":"axons","score":0.6200000047683716},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/environmental-stimulation","display_name":"environmental stimulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nutrition","display_name":"nutrition","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.4230000078678131},{"id":"https://openalex.org/keywords/glycophospholipids","display_name":"glycophospholipids","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7559940814971924},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7551804780960083},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6628769636154175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6211365461349487},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5323904752731323},{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.49988770484924316},{"id":"https://openalex.org/C178300618","wikidata":"https://www.wikidata.org/wiki/Q1898509","display_name":"Extant taxon","level":2,"score":0.4816093146800995},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.4780438542366028},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4290015697479248},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4185260832309723},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34635215997695923},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.1179656982421875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11388698220252991},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:periodicos.unicesumar.edu.br:article/1654","doi":null,"is_oa":true,"landing_page_url":"https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1654","pdf_url":null,"source":{"id":"https://openalex.org/S2738224174","display_name":"Sa\u00fade e Pesquisa","issn_l":"1983-1870","issn":["1983-1870","2176-9206"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312112","host_organization_name":"Universidade Cesumar","host_organization_lineage":["https://openalex.org/P4310312112"],"host_organization_lineage_names":["Universidade Cesumar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2176-9206","raw_type":"Revis\u00e3o de literatura"}],"best_oa_location":{"id":"pmh:oai:periodicos.unicesumar.edu.br:article/1654","doi":null,"is_oa":true,"landing_page_url":"https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1654","pdf_url":null,"source":{"id":"https://openalex.org/S2738224174","display_name":"Sa\u00fade e Pesquisa","issn_l":"1983-1870","issn":["1983-1870","2176-9206"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312112","host_organization_name":"Universidade Cesumar","host_organization_lineage":["https://openalex.org/P4310312112"],"host_organization_lineage_names":["Universidade Cesumar"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2176-9206","raw_type":"Revis\u00e3o de literatura"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1969821478","https://openalex.org/W2014186370","https://openalex.org/W2015748290","https://openalex.org/W2018440098","https://openalex.org/W2018558728","https://openalex.org/W2031106541","https://openalex.org/W2033560185","https://openalex.org/W2035963692","https://openalex.org/W2037060258","https://openalex.org/W2043259162","https://openalex.org/W2046564493","https://openalex.org/W2077081354","https://openalex.org/W2087260851","https://openalex.org/W2112873940","https://openalex.org/W2115585096","https://openalex.org/W2122772224","https://openalex.org/W2127621191","https://openalex.org/W2153393262","https://openalex.org/W2162689717","https://openalex.org/W3167162497"],"related_works":["https://openalex.org/W7133545035","https://openalex.org/W1161758876","https://openalex.org/W2151106401","https://openalex.org/W4285191495","https://openalex.org/W1842838667","https://openalex.org/W151876241","https://openalex.org/W3167477394","https://openalex.org/W2028030425","https://openalex.org/W4409833831","https://openalex.org/W67320361"],"abstract_inverted_index":{"Myelin,":[0],"a":[1,5],"structure":[2],"formed":[3],"by":[4],"lipid":[6],"membrane":[7],"rich":[8],"in":[9,48,76],"cholesterol":[10],"and":[11,16,26,65,85,89,122,131,138],"glycophospholipids,":[12],"envelops":[13],"the":[14,18,28,38,49,52,57,77,94,97,118],"axons":[15,88],"facilitates":[17],"rapid":[19],"communication":[20],"between":[21],"neurons.":[22],"Oligodendrocytes,":[23],"which":[24],"synthesize":[25],"maintain":[27],"myelin":[29,98,121],"sheath,":[30],"are":[31],"highly":[32],"specialized,":[33],"albeit":[34],"vulnerable,":[35],"cells":[36],"of":[37,55,59,96,120],"central":[39],"nervous":[40,78],"system":[41],"(CNS).":[42],"The":[43],"white":[44],"matter\u2019s":[45],"myelinated":[46],"tracts":[47],"CNS":[50],"have":[51,70],"important":[53],"role":[54],"promoting":[56],"transmission":[58],"neural":[60],"signals":[61],"among":[62],"different":[63],"cortical":[64],"subcortical":[66],"areas.":[67],"Although":[68],"experiments":[69],"shown":[71],"that":[72,124],"plasticity":[73],"is":[74,100],"extant":[75],"system,":[79],"especially":[80],"with":[81],"regard":[82],"to":[83],"neurons":[84],"their":[86,125],"dendrites,":[87],"synapses,":[90],"doubts":[91],"remained":[92],"whether":[93,106],"formation":[95],"sheath":[99],"dependent":[101],"on":[102,117,128],"genetic":[103],"factors":[104],"or":[105],"external":[107,132],"experiences":[108],"change":[109],"this":[110],"structure.":[111],"Current":[112],"exploratory":[113],"research":[114],"identified":[115],"theories":[116],"development":[119,126],"shows":[123],"depends":[127],"internal":[129],"(genetic)":[130],"factors,":[133],"such":[134],"as":[135],"environmental":[136],"stimulation":[137],"nutrition.":[139]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2026-10-03T00:00:00"}
