{"id":"https://openalex.org/W1663004000","doi":"https://doi.org/10.1016/j.jconrel.2015.05.274","title":"Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan\u2013poly(ethylene imine) hybrid nanoparticles: A mechanistic insight","display_name":"Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan\u2013poly(ethylene imine) hybrid nanoparticles: A mechanistic insight","publication_year":2015,"publication_date":"2015-05-16","ids":{"openalex":"https://openalex.org/W1663004000","doi":"https://doi.org/10.1016/j.jconrel.2015.05.274","mag":"1663004000","pmid":"https://pubmed.ncbi.nlm.nih.gov/25989603"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2015.05.274","doi":"https://doi.org/10.1016/j.jconrel.2015.05.274","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.05.274","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031735211","display_name":"H\u00e9lo\u00efse Ragelle","orcid":"https://orcid.org/0000-0003-0650-9601","observed_orcids":["https://orcid.org/0000-0003-0650-9601"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"H\u00e9lo\u00efse Ragelle","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061885471","display_name":"Stefano Colombo","orcid":"https://orcid.org/0000-0002-5259-4600","observed_orcids":["https://orcid.org/0000-0002-5259-4600"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stefano Colombo","raw_affiliation_strings":["University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, Section for Biologics, Universitetsparken 2, 2100 Copenhagen O, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, Section for Biologics, Universitetsparken 2, 2100 Copenhagen O, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021857885","display_name":"Vincent Pourcelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Vincent Pourcelle","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Molecules, Solids and Reactivity, Institute of Condensed Matter and Nanosciences, 1348 Louvain-la-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Molecules, Solids and Reactivity, Institute of Condensed Matter and Nanosciences, 1348 Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057668117","display_name":"K\u00e9vin Vanvarenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kevin Vanvarenberg","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051387030","display_name":"Ga\u00eblle Vandermeulen","orcid":"https://orcid.org/0000-0002-8696-9642","observed_orcids":["https://orcid.org/0000-0002-8696-9642"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ga\u00eblle Vandermeulen","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039129582","display_name":"Caroline Bouzin","orcid":"https://orcid.org/0000-0003-0694-1947","observed_orcids":["https://orcid.org/0000-0003-0694-1947"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Caroline Bouzin","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Institut de Recherche Clinique et Exp\u00e9rimentale, Pole of Pharmacology and Therapeutics, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Institut de Recherche Clinique et Exp\u00e9rimentale, Pole of Pharmacology and Therapeutics, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895123","display_name":"Jacqueline Marchand\u2010Brynaert","orcid":"https://orcid.org/0000-0003-2642-3223","observed_orcids":["https://orcid.org/0000-0003-2642-3223"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jacqueline Marchand-Brynaert","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Molecules, Solids and Reactivity, Institute of Condensed Matter and Nanosciences, 1348 Louvain-la-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Molecules, Solids and Reactivity, Institute of Condensed Matter and Nanosciences, 1348 Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059376263","display_name":"Olivier F\u00e9ron","orcid":"https://orcid.org/0000-0001-5360-0286","observed_orcids":["https://orcid.org/0000-0001-5360-0286"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Olivier Feron","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Institut de Recherche Clinique et Exp\u00e9rimentale, Pole of Pharmacology and Therapeutics, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Institut de Recherche Clinique et Exp\u00e9rimentale, Pole of Pharmacology and Therapeutics, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042180788","display_name":"Camilla Foged","orcid":"https://orcid.org/0000-0003-2812-5588","observed_orcids":["https://orcid.org/0000-0003-2812-5588"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Camilla Foged","raw_affiliation_strings":["University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, Section for Biologics, Universitetsparken 2, 2100 Copenhagen O, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Copenhagen, Faculty of Health and Medical Sciences, Department of Pharmacy, Section for Biologics, Universitetsparken 2, 2100 Copenhagen O, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001987906","display_name":"V\u00e9ronique Pr\u00e9at A","orcid":"https://orcid.org/0000-0002-4045-1450","observed_orcids":["https://orcid.org/0000-0002-4045-1450"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"V\u00e9ronique Pr\u00e9at","raw_affiliation_strings":["Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001987906","https://openalex.org/A5042180788"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I95674353"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":3.2304,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.93279594,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"211","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9860000014305115},{"id":"https://openalex.org/keywords/alphavbeta3-integrin-targeting","display_name":"\u03b1v\u03b23 integrin targeting","score":0.9039999842643738},{"id":"https://openalex.org/keywords/rgd-ligand","display_name":"RGD ligand","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.8360000252723694},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.7200000286102295},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6980000138282776},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/h1299-cells","display_name":"H1299 cells","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6627523303031921},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6407122611999512},{"id":"https://openalex.org/C2776573223","wikidata":"https://www.wikidata.org/wiki/Q408057","display_name":"Imine","level":3,"score":0.6179375648498535},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.5877730250358582},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4949299693107605},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.482807993888855},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4753448963165283},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.46921172738075256},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.42583978176116943},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.42274829745292664},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35555875301361084},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28697526454925537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2687215805053711},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20002412796020508},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.14284977316856384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14162716269493103},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14015516638755798},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1025921106338501},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007097","descriptor_name":"Imines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011095","descriptor_name":"Polyethylenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jconrel.2015.05.274","doi":"https://doi.org/10.1016/j.jconrel.2015.05.274","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.05.274","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25989603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25989603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:160584","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/160584","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Controlled Release, Vol. 211, p. 1-9 (2015)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/884b3758-375f-4e52-8ab0-b3c988dddd31","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/884b3758-375f-4e52-8ab0-b3c988dddd31","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ragelle, H, Colombo, S, Pourcelle, V, Vanvarenberg, K, Vandermeulen, G, Bouzin, C, Marchand-Brynaert, J, Feron, O, Foged, C & Pr\u00e9at, V 2015, 'Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles : A mechanistic insight', Journal of Controlled Release, vol. 211, pp. 1-9. https://doi.org/10.1016/j.jconrel.2015.05.274","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7266910946","display_name":null,"funder_award_id":"2010_01_0294","funder_id":"https://openalex.org/F4320321504","funder_display_name":"Carlsbergfondet"}],"funders":[{"id":"https://openalex.org/F4320318621","display_name":"Waalse Gewest","ror":null},{"id":"https://openalex.org/F4320320945","display_name":"K\u00f8benhavns Universitet","ror":"https://ror.org/035b05819"},{"id":"https://openalex.org/F4320321504","display_name":"Carlsbergfondet","ror":"https://ror.org/01kpjmx04"},{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320334770","display_name":"Danish Agency for Science and Higher Education","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320335133","display_name":"Drug Research Academy, K\u00f8benhavns Universitet","ror":"https://ror.org/035b05819"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W68837490","https://openalex.org/W1921474434","https://openalex.org/W1964307166","https://openalex.org/W1969404954","https://openalex.org/W1969961099","https://openalex.org/W1981409038","https://openalex.org/W1984574632","https://openalex.org/W1985755069","https://openalex.org/W1987355699","https://openalex.org/W1989403240","https://openalex.org/W1995770815","https://openalex.org/W2001609281","https://openalex.org/W2009696358","https://openalex.org/W2019154422","https://openalex.org/W2019267098","https://openalex.org/W2025344276","https://openalex.org/W2037096236","https://openalex.org/W2041001892","https://openalex.org/W2042949277","https://openalex.org/W2044074008","https://openalex.org/W2049262810","https://openalex.org/W2057704227","https://openalex.org/W2062685308","https://openalex.org/W2068295615","https://openalex.org/W2086393160","https://openalex.org/W2086580672","https://openalex.org/W2091993321","https://openalex.org/W2100240517","https://openalex.org/W2113181942","https://openalex.org/W2140282212","https://openalex.org/W2150647656","https://openalex.org/W2152170788","https://openalex.org/W2154899729","https://openalex.org/W2160251401","https://openalex.org/W2160272852","https://openalex.org/W2163627968","https://openalex.org/W2164641603","https://openalex.org/W2169940012","https://openalex.org/W2170409382","https://openalex.org/W2404074437"],"related_works":["https://openalex.org/W2150647656","https://openalex.org/W2472803187","https://openalex.org/W1969961099","https://openalex.org/W2526371533","https://openalex.org/W2186703841","https://openalex.org/W2064433155","https://openalex.org/W2206985701","https://openalex.org/W1988977628","https://openalex.org/W2093363014","https://openalex.org/W2411190461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}