{"id":"https://openalex.org/W1662823788","doi":"https://doi.org/10.1128/jcm.11.6.573-578.1980","title":"Enzyme-linked immunosorbent assay for detection of Haemophilus influenzae type b antigen","display_name":"Enzyme-linked immunosorbent assay for detection of Haemophilus influenzae type b antigen","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W1662823788","doi":"https://doi.org/10.1128/jcm.11.6.573-578.1980","mag":"1662823788","pmid":"https://pubmed.ncbi.nlm.nih.gov/7000809","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/273463"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.11.6.573-578.1980","doi":"https://doi.org/10.1128/jcm.11.6.573-578.1980","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.11.6.573-578.1980","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC273463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029340883","display_name":"B L Wetherall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"B L Wetherall","raw_affiliation_strings":["Flinders Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flinders Medical Centre","institution_ids":["https://openalex.org/I2802931750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111821165","display_name":"Peter G. Hallsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P G Hallsworth","raw_affiliation_strings":["Flinders Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flinders Medical Centre","institution_ids":["https://openalex.org/I2802931750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090694666","display_name":"Peter J. McDonald","orcid":"https://orcid.org/0000-0001-6875-1466","observed_orcids":["https://orcid.org/0000-0001-6875-1466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J McDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8127,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88414097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"11","issue":"6","first_page":"573","last_page":"578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-b","display_name":"Haemophilus influenzae type b","score":0.9990000128746033},{"id":"https://openalex.org/keywords/elisa","display_name":"ELISA","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8870000243186951},{"id":"https://openalex.org/keywords/meningitis","display_name":"meningitis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/urinary-antigen-detection","display_name":"urine antigen detection","score":0.6909999847412109},{"id":"https://openalex.org/keywords/serum-antigen-detection","display_name":"serum antigen detection","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/staphylococcus-aureus-protein-a","display_name":"Staphylococcus aureus protein A","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C37177560","wikidata":"https://www.wikidata.org/wiki/Q5176977","display_name":"Counterimmunoelectrophoresis","level":3,"score":0.9060198068618774},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6802661418914795},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.6522853374481201},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5446675419807434},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.5292274951934814},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5236492156982422},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.4959131181240082},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4446479082107544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3985687494277954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37815967202186584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.200876384973526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19875627756118774},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003378","descriptor_name":"Counterimmunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008583","descriptor_name":"Meningitis, Haemophilus","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jcm.11.6.573-578.1980","doi":"https://doi.org/10.1128/jcm.11.6.573-578.1980","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.11.6.573-578.1980","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:230612","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC273463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:273463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/273463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},{"id":"pmid:7000809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7000809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:230612","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC273463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W53070584","https://openalex.org/W158623349","https://openalex.org/W1508252542","https://openalex.org/W1575357119","https://openalex.org/W1660327699","https://openalex.org/W1952620523","https://openalex.org/W1974463669","https://openalex.org/W1974952962","https://openalex.org/W1983750209","https://openalex.org/W1986241242","https://openalex.org/W1988807021","https://openalex.org/W1996469539","https://openalex.org/W1998916302","https://openalex.org/W2001646312","https://openalex.org/W2004563770","https://openalex.org/W2006664151","https://openalex.org/W2008307666","https://openalex.org/W2020659177","https://openalex.org/W2031138522","https://openalex.org/W2036062808","https://openalex.org/W2051897434","https://openalex.org/W2061636588","https://openalex.org/W2062956316","https://openalex.org/W2070303924","https://openalex.org/W2082063184","https://openalex.org/W2084855813","https://openalex.org/W2093772713","https://openalex.org/W2108380649","https://openalex.org/W2132465529","https://openalex.org/W2134129133","https://openalex.org/W2297222562","https://openalex.org/W2318716813","https://openalex.org/W2319453325","https://openalex.org/W2321461976","https://openalex.org/W2438226450","https://openalex.org/W2774846296"],"related_works":["https://openalex.org/W1528618952","https://openalex.org/W1819596534","https://openalex.org/W2297222562","https://openalex.org/W1511988025","https://openalex.org/W1964863503","https://openalex.org/W1947525407","https://openalex.org/W1998916302","https://openalex.org/W2058385959","https://openalex.org/W1576553663","https://openalex.org/W23094592"],"abstract_inverted_index":{"An":[0],"enzyme-linked":[1,166],"immunosorbent":[2,167],"assay":[3,144,168,187],"for":[4,50,99,194,205],"the":[5,45,102,105,124,140,143,165,185,195,206,209],"detection":[6,207],"of":[7,25,95,107,112,118,121,123,130,133,142,159,197,208],"Haemophilus":[8],"influenzae":[9,136,177],"type":[10,137,178],"b":[11,138,179],"antigen":[12,210],"was":[13,16,37,55,61,97,148],"developed.":[14],"It":[15],"able":[17],"to":[18,30,150,183],"detect":[19],"purified":[20],"polyribose":[21,51],"phosphate":[22,52],"at":[23,152],"concentrations":[24],"greater":[26,156],"than":[27,42,157],"or":[28],"equal":[29],"1":[31],"ng/ml":[32],"in":[33,53,59,101,174,211],"cerebrospinal":[34,72,146,212],"fluid.":[35],"This":[36],"50":[38],"times":[39,64,155],"more":[40],"sensitive":[41,171],"counterimmunoelectrophoresis":[43],"with":[44,70,88,145],"same":[46],"antiserum.":[47],"The":[48,161,181],"sensitivity":[49,141],"urine":[54],"similar,":[56],"but":[57],"that":[58,122,158,164],"serum":[60],"about":[62],"10":[63],"less.":[65],"Nonspecific":[66],"reactions":[67,83],"were":[68,78],"observed":[69],"blood-stained":[71],"fluid":[73,147,213],"and":[74,172,214],"some":[75],"sera.":[76],"These":[77],"differentiated":[79],"from":[80],"true":[81],"positive":[82],"by":[84],"a":[85,108,128],"blocking":[86,186],"test":[87],"unconjugated":[89],"immune":[90],"serum.":[91],"A":[92],"wide":[93],"range":[94],"organisms":[96],"tested":[98],"cross-reactivity":[100],"assay.":[103],"With":[104],"exception":[106],"protein":[109],"A-rich":[110],"strain":[111],"Staphylococcus":[113],"aureus,":[114],"they":[115],"gave":[116],"absorbances":[117],"<":[119],"8%":[120],"homologous":[125],"system.":[126],"In":[127],"series":[129],"five":[131],"cases":[132],"proven":[134],"H.":[135,176],"meningitis,":[139],"confirmed":[149],"be":[151],"least":[153],"2(5)":[154],"counterimmunoelectrophoresis.":[160],"results":[162],"indicate":[163],"is":[169],"highly":[170],"specific":[173],"detecting":[175],"antigen.":[180],"necessity":[182],"perform":[184],"on":[188],"all":[189],"sera":[190],"limits":[191],"its":[192],"usefulness":[193],"examination":[196],"these":[198],"specimens.":[199],"However,":[200],"it":[201],"should":[202],"prove":[203],"valuable":[204],"urine.":[215]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
