{"id":"https://openalex.org/W166256027","doi":null,"title":"Theory of antimotion sickness drug mechanisms.","display_name":"Theory of antimotion sickness drug mechanisms.","publication_year":1972,"publication_date":"1972-03-01","ids":{"openalex":"https://openalex.org/W166256027","mag":"166256027","pmid":"https://pubmed.ncbi.nlm.nih.gov/4402925"},"language":"en","primary_location":{"id":"pmid:4402925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4402925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aerospace medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C D Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107226","display_name":"Naval Aerospace Medical Research Laboratory","ror":"https://ror.org/01gsy1c54","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4210107226","https://openalex.org/I4399598358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C D Wood","raw_affiliation_strings":["U.S. Naval Aerospace Medical Laboratory Pensacola, Fla., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Naval Aerospace Medical Laboratory Pensacola, Fla., United States","institution_ids":["https://openalex.org/I4210107226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078404399","display_name":"Ashton Graybiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I26489229","display_name":"Louisiana State University in Shreveport","ror":"https://ror.org/02c4cbt39","country_code":"US","type":"education","lineage":["https://openalex.org/I26489229"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Graybiel","raw_affiliation_strings":["Louisiana State University Shreveport, La., United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Shreveport, La., United States","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I26489229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4527,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.85822062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"43","issue":"3","first_page":"249","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motion-sickness","display_name":"motion sickness","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.8460000157356262},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8949999809265137},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/vestibular-system","display_name":"vestibular system","score":0.7379999756813049},{"id":"https://openalex.org/keywords/reticular-formation","display_name":"reticular formation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6209999918937683},{"id":"https://openalex.org/keywords/parasympathetic-activity","display_name":"parasympathetic activity","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.9661997556686401},{"id":"https://openalex.org/C2778689640","wikidata":"https://www.wikidata.org/wiki/Q113259","display_name":"Anticholinergic","level":2,"score":0.685468316078186},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5434125065803528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5433602333068848},{"id":"https://openalex.org/C2778655484","wikidata":"https://www.wikidata.org/wiki/Q750588","display_name":"Reticular formation","level":3,"score":0.5364305377006531},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.5050521492958069},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45467907190322876},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4412488043308258},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.43975603580474854},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4149215519428253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3755861520767212},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3223607540130615},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.27302664518356323},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.23489564657211304},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2282356321811676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16933360695838928},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11643964052200317},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.08026769757270813}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010640","descriptor_name":"Phenothiazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012601","descriptor_name":"Scopolamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013565","descriptor_name":"Sympatholytics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:4402925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4402925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aerospace medicine","raw_type":"Journal Article"},{"id":"mag:166256027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4402925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2410285692","https://openalex.org/W74990507","https://openalex.org/W7009630234","https://openalex.org/W2396303122","https://openalex.org/W1965081297","https://openalex.org/W1835056257","https://openalex.org/W3028152157","https://openalex.org/W2905104301","https://openalex.org/W266632260","https://openalex.org/W2011865303"],"abstract_inverted_index":{"The":[0,29,41],"results":[1],"of":[2,5,31,43,85],"a":[3,35,54],"series":[4],"antimotion":[6],"sickness":[7,69],"drug":[8],"evaluations":[9],"indicates":[10],"that":[11,19,79],"drugs":[12,18],"with":[13],"central":[14,21,47],"anticholinergic":[15],"actions":[16,33],"and":[17,63,70,73],"increase":[20],"sympathetic":[22,72],"activity":[23],"are":[24],"effective":[25],"against":[26,38],"motion":[27,39,68,89],"sickness.":[28,40,90],"combination":[30],"these":[32,44],"produces":[34],"synergistic":[36],"effect":[37,42],"medications":[45],"on":[46,50],"acetylcholine":[48],"or":[49],"norepinephrine":[51],"could":[52,81],"alter":[53],"balance":[55],"between":[56],"the":[58,61],"neurons":[59],"in":[60,87],"vestibular":[62],"reticular":[64],"areas":[65],"which":[66],"influence":[67],"also":[71],"parasympathetic":[74],"reactions.":[75],"It":[76],"is":[77],"suggested":[78],"this":[80],"be":[82],"their":[83],"mechanism":[84],"action":[86],"preventing":[88]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}