{"id":"https://openalex.org/W1662558499","doi":"https://doi.org/10.1186/cc1509","title":"Lactate: A key metabolite in the intercellular metabolic interplay.","display_name":"Lactate: A key metabolite in the intercellular metabolic interplay.","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1662558499","doi":"https://doi.org/10.1186/cc1509","mag":"1662558499","pmid":"https://pubmed.ncbi.nlm.nih.gov/12225597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/137304"},"language":"en","primary_location":{"id":"doi:10.1186/cc1509","doi":"https://doi.org/10.1186/cc1509","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc1509","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1509","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111884261","display_name":"Xavier Maurice Leverve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210153067","display_name":"Laboratory of Fundamental and Applied Bioenergetics","ror":"https://ror.org/05514hp74","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210153067","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Xavier M Leverve","raw_affiliation_strings":["Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, INSERM E0221 & Universit\u00e9 Joseph Fourier, Grenoble, France. xavier.leverve@ujf-grenoble.fr","Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, Universit\u00e9 Joseph Fourier, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, INSERM E0221 & Universit\u00e9 Joseph Fourier, Grenoble, France. xavier.leverve@ujf-grenoble.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177483745","https://openalex.org/I4210153067"]},{"raw_affiliation_string":"Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, Universit\u00e9 Joseph Fourier, Grenoble, France","institution_ids":["https://openalex.org/I177483745","https://openalex.org/I4210153067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111477535","display_name":"Iqbal Mustafa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210153067","display_name":"Laboratory of Fundamental and Applied Bioenergetics","ror":"https://ror.org/05514hp74","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210153067","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Iqbal Mustafa","raw_affiliation_strings":["Intensive Care Unit, Harapan Kita National Cardiovascular Center, Jakarta, Indonesia","Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, Universit\u00e9 Joseph Fourier, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Harapan Kita National Cardiovascular Center, Jakarta, Indonesia","institution_ids":[]},{"raw_affiliation_string":"Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e, Universit\u00e9 Joseph Fourier, Grenoble, France","institution_ids":["https://openalex.org/I177483745","https://openalex.org/I4210153067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111884261"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177483745","https://openalex.org/I4210153067"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.5083,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.80257235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"284","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8637999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cori-cycle","display_name":"Cori cycle","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lactate-metabolism","display_name":"lactate metabolism","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lactate-infusion","display_name":"lactate infusion","score":0.7289999723434448},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.5329999923706055},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7042765617370605},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6978625059127808},{"id":"https://openalex.org/C2992422156","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Blood lactate","level":4,"score":0.4458959102630615},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43826931715011597},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3256581425666809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27851831912994385},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06610369682312012},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/cc1509","doi":"https://doi.org/10.1186/cc1509","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc1509","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1509","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:99690","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC137304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:12225597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12225597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:137304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC137304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.284.3816","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.284.3816","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/35/14/Crit_Care_2002_Jul_8_6(4)_284-285.tar.gz","raw_type":"text"},{"id":"pmh:oai:HAL:inserm-00123606v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00123606","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care, 2002, 6 (4), pp.284-5","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2345149301","doi":null,"is_oa":false,"landing_page_url":"https://www.hal.inserm.fr/inserm-00123606/document","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/cc1509","doi":"https://doi.org/10.1186/cc1509","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc1509","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1509","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1662558499.pdf","grobid_xml":"https://content.openalex.org/works/W1662558499.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W281437963","https://openalex.org/W1631919274","https://openalex.org/W1823768960","https://openalex.org/W1847647945","https://openalex.org/W1966445111","https://openalex.org/W1987632324","https://openalex.org/W1990158364","https://openalex.org/W2017790389","https://openalex.org/W2056934253","https://openalex.org/W2063615838","https://openalex.org/W2072147744","https://openalex.org/W2079221404","https://openalex.org/W2100459468","https://openalex.org/W2102251955","https://openalex.org/W2133615329","https://openalex.org/W2139155172","https://openalex.org/W2140192657","https://openalex.org/W2143455563","https://openalex.org/W2149451900","https://openalex.org/W2158112542","https://openalex.org/W2158679643","https://openalex.org/W2335100451","https://openalex.org/W2343808174","https://openalex.org/W2398299485","https://openalex.org/W2419051019"],"related_works":["https://openalex.org/W2345149301","https://openalex.org/W34877409","https://openalex.org/W2512409286","https://openalex.org/W7212132695","https://openalex.org/W1981085657","https://openalex.org/W1954250865","https://openalex.org/W7098281118","https://openalex.org/W2887676242","https://openalex.org/W2181805890","https://openalex.org/W1595106453"],"abstract_inverted_index":{"Most":[0],"physicians":[1],"involved":[2],"in":[3,20,38],"intensive":[4],"care":[5],"consider":[6],"lactate":[7,27,59],"solely":[8],"as":[9,92],"a":[10,29,89,93],"deleterious":[11],"metabolite,":[12,31],"responsible":[13],"for":[14,98],"high":[15],"morbidity":[16],"and":[17,52,76],"bad":[18,56],"prognosis":[19],"severe":[21],"patients.":[22],"For":[23],"the":[24,39,55],"physiologist,":[25],"however,":[26],"is":[28,60],"key":[30],"alternatively":[32],"produced":[33],"or":[34,44],"consumed.":[35],"Many":[36],"studies":[37],"literature":[40],"have":[41],"infused":[42],"animals":[43],"humans":[45],"with":[46],"exogenous":[47],"lactate,":[48,83],"demonstrating":[49],"its":[50,70],"safety":[51],"usefulness,":[53],"but":[54],"reputation":[57],"of":[58,66],"still":[61],"widespread.":[62],"The":[63],"metabolic":[64],"meaning":[65],"glucose\u2013lactate":[67],"cycling":[68],"exceeds":[69],"initial":[71],"role":[72,91],"described":[73],"by":[74],"Cori":[75],"Cori.":[77],"According":[78],"to":[79],"recent":[80],"works":[81],"concerning":[82],"it":[84],"can":[85],"be":[86],"predicted":[87],"that":[88],"new":[90],"therapeutic":[94],"agent":[95],"will":[96],"arise":[97],"this":[99],"metabolite.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}