{"id":"https://openalex.org/W166253151","doi":null,"title":"Immunomodulatory effects of interferon-alpha on T cell subsets in Behcet's disease ex vivo, and the in vitro effects of treatment on healthy donor cells","display_name":"Immunomodulatory effects of interferon-alpha on T cell subsets in Behcet's disease ex vivo, and the in vitro effects of treatment on healthy donor cells","publication_year":2012,"publication_date":"2012-01-28","ids":{"openalex":"https://openalex.org/W166253151","mag":"166253151"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1339147","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1339147/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108095553","display_name":"David S. Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108095553"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/behcet-s-disease","display_name":"Beh\u00e7et's disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/interferon-alpha-therapy","display_name":"interferon-alpha therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.9520000219345093},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foxp3-regulatory-t-cells","display_name":"Foxp3+ regulatory T cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.7279999852180481},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.972000002861023},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7008126378059387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6537890434265137},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6399824023246765},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5739752650260925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5667570233345032},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5582707524299622},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4964516758918762},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.47795796394348145},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4668980538845062},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4300851821899414},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4207209348678589},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4158138632774353},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37706321477890015},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37074944376945496},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26382866501808167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.261157751083374},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1339147","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1339147/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:166253151","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/id/eprint/1339147/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":379,"referenced_works":["https://openalex.org/W41567438","https://openalex.org/W110928060","https://openalex.org/W117983187","https://openalex.org/W147041937","https://openalex.org/W147952742","https://openalex.org/W152687799","https://openalex.org/W163688438","https://openalex.org/W164934141","https://openalex.org/W180054770","https://openalex.org/W183054515","https://openalex.org/W193988159","https://openalex.org/W200868442","https://openalex.org/W750687577","https://openalex.org/W1510081630","https://openalex.org/W1519893388","https://openalex.org/W1520953238","https://openalex.org/W1526621387","https://openalex.org/W1530782041","https://openalex.org/W1537063289","https://openalex.org/W1537128240","https://openalex.org/W1538802759","https://openalex.org/W1547412330","https://openalex.org/W1560277370","https://openalex.org/W1560393239","https://openalex.org/W1561046927","https://openalex.org/W1563534174","https://openalex.org/W1570163412","https://openalex.org/W1574687977","https://openalex.org/W1575585006","https://openalex.org/W1577017898","https://openalex.org/W1587849076","https://openalex.org/W1588272261","https://openalex.org/W1594758412","https://openalex.org/W1601211391","https://openalex.org/W1619765116","https://openalex.org/W1642448589","https://openalex.org/W1652051777","https://openalex.org/W1761643547","https://openalex.org/W1789654384","https://openalex.org/W1790309941","https://openalex.org/W1821802349","https://openalex.org/W1837576575","https://openalex.org/W1847326477","https://openalex.org/W1849241381","https://openalex.org/W1867019379","https://openalex.org/W1877879829","https://openalex.org/W1906604627","https://openalex.org/W1934211904","https://openalex.org/W1942668068","https://openalex.org/W1948242446","https://openalex.org/W1964444977","https://openalex.org/W1966073503","https://openalex.org/W1966922635","https://openalex.org/W1966976136","https://openalex.org/W1968697332","https://openalex.org/W1970548110","https://openalex.org/W1972298566","https://openalex.org/W1972554083","https://openalex.org/W1972717746","https://openalex.org/W1974004289","https://openalex.org/W1974339623","https://openalex.org/W1974781378","https://openalex.org/W1976168572","https://openalex.org/W1976783221","https://openalex.org/W1978068431","https://openalex.org/W1980050753","https://openalex.org/W1980294413","https://openalex.org/W1980780108","https://openalex.org/W1981124806","https://openalex.org/W1981651463","https://openalex.org/W1982243301","https://openalex.org/W1982926364","https://openalex.org/W1983150631","https://openalex.org/W1983899969","https://openalex.org/W1984279003","https://openalex.org/W1984429004","https://openalex.org/W1985126564","https://openalex.org/W1986217661","https://openalex.org/W1986938885","https://openalex.org/W1987069221","https://openalex.org/W1987119060","https://openalex.org/W1987628377","https://openalex.org/W1988317772","https://openalex.org/W1989765674","https://openalex.org/W1990762234","https://openalex.org/W1991344211","https://openalex.org/W1991600170","https://openalex.org/W1992547979","https://openalex.org/W1993292726","https://openalex.org/W1993539774","https://openalex.org/W1995930566","https://openalex.org/W1996363503","https://openalex.org/W1996811838","https://openalex.org/W1997605939","https://openalex.org/W1997911081","https://openalex.org/W1999278480","https://openalex.org/W1999305187","https://openalex.org/W1999833479","https://openalex.org/W1999875730","https://openalex.org/W2000107960","https://openalex.org/W2000132633","https://openalex.org/W2000391752","https://openalex.org/W2001235261","https://openalex.org/W2001860826","https://openalex.org/W2001990486","https://openalex.org/W2002289822","https://openalex.org/W2002654377","https://openalex.org/W2002726823","https://openalex.org/W2003626573","https://openalex.org/W2003652884","https://openalex.org/W2005105843","https://openalex.org/W2005227771","https://openalex.org/W2006192376","https://openalex.org/W2006249161","https://openalex.org/W2006732787","https://openalex.org/W2007631222","https://openalex.org/W2008195886","https://openalex.org/W2008713912","https://openalex.org/W2008783725","https://openalex.org/W2009083228","https://openalex.org/W2009155901","https://openalex.org/W2011701106","https://openalex.org/W2011754426","https://openalex.org/W2012097777","https://openalex.org/W2012107785","https://openalex.org/W2012114706","https://openalex.org/W2013146483","https://openalex.org/W2013181138","https://openalex.org/W2014553274","https://openalex.org/W2014913358","https://openalex.org/W2016191219","https://openalex.org/W2016297238","https://openalex.org/W2017896938","https://openalex.org/W2018954400","https://openalex.org/W2019002141","https://openalex.org/W2019323646","https://openalex.org/W2019615790","https://openalex.org/W2021687886","https://openalex.org/W2022022565","https://openalex.org/W2022050925","https://openalex.org/W2023825608","https://openalex.org/W2024152763","https://openalex.org/W2025813691","https://openalex.org/W2026028987","https://openalex.org/W2026578316","https://openalex.org/W2026629764","https://openalex.org/W2026942934","https://openalex.org/W2027757480","https://openalex.org/W2028404309","https://openalex.org/W2028476437","https://openalex.org/W2028763115","https://openalex.org/W2028950350","https://openalex.org/W2030407028","https://openalex.org/W2030519257","https://openalex.org/W2030682069","https://openalex.org/W2031155625","https://openalex.org/W2031357408","https://openalex.org/W2033144954","https://openalex.org/W2033330275","https://openalex.org/W2037259928","https://openalex.org/W2037299986","https://openalex.org/W2037920661","https://openalex.org/W2039198873","https://openalex.org/W2039992202","https://openalex.org/W2040041622","https://openalex.org/W2040112038","https://openalex.org/W2040235283","https://openalex.org/W2040282375","https://openalex.org/W2041563880","https://openalex.org/W2041669657","https://openalex.org/W2041820432","https://openalex.org/W2041995906","https://openalex.org/W2041996934","https://openalex.org/W2042163461","https://openalex.org/W2042586707","https://openalex.org/W2043577668","https://openalex.org/W2045343528","https://openalex.org/W2046388159","https://openalex.org/W2046459432","https://openalex.org/W2047547740","https://openalex.org/W2049946738","https://openalex.org/W2050514979","https://openalex.org/W2053763669","https://openalex.org/W2053889157","https://openalex.org/W2054472394","https://openalex.org/W2054759185","https://openalex.org/W2054772929","https://openalex.org/W2056756250","https://openalex.org/W2057631395","https://openalex.org/W2060527543","https://openalex.org/W2060546545","https://openalex.org/W2060608469","https://openalex.org/W2060716894","https://openalex.org/W2060905466","https://openalex.org/W2060926084","https://openalex.org/W2061217789","https://openalex.org/W2061352717","https://openalex.org/W2061401593","https://openalex.org/W2062505270","https://openalex.org/W2062559732","https://openalex.org/W2062656174","https://openalex.org/W2064376469","https://openalex.org/W2065400561","https://openalex.org/W2065434106","https://openalex.org/W2066117529","https://openalex.org/W2066332211","https://openalex.org/W2068023618","https://openalex.org/W2068318977","https://openalex.org/W2068574209","https://openalex.org/W2068859282","https://openalex.org/W2069347195","https://openalex.org/W2070492445","https://openalex.org/W2071715296","https://openalex.org/W2072488504","https://openalex.org/W2073514389","https://openalex.org/W2073580835","https://openalex.org/W2074256942","https://openalex.org/W2075940342","https://openalex.org/W2076582370","https://openalex.org/W2076889715","https://openalex.org/W2079595796","https://openalex.org/W2079751097","https://openalex.org/W2081147074","https://openalex.org/W2081689799","https://openalex.org/W2082044960","https://openalex.org/W2082450021","https://openalex.org/W2082871926","https://openalex.org/W2084439292","https://openalex.org/W2084538143","https://openalex.org/W2084858972","https://openalex.org/W2085402152","https://openalex.org/W2087414232","https://openalex.org/W2087905758","https://openalex.org/W2088009450","https://openalex.org/W2089840168","https://openalex.org/W2090831287","https://openalex.org/W2091533096","https://openalex.org/W2092734423","https://openalex.org/W2092975931","https://openalex.org/W2093264896","https://openalex.org/W2095319273","https://openalex.org/W2095351296","https://openalex.org/W2095405069","https://openalex.org/W2095650137","https://openalex.org/W2095671247","https://openalex.org/W2095803590","https://openalex.org/W2096193102","https://openalex.org/W2097057955","https://openalex.org/W2097404490","https://openalex.org/W2097811455","https://openalex.org/W2098365610","https://openalex.org/W2099229060","https://openalex.org/W2100729456","https://openalex.org/W2102258628","https://openalex.org/W2103600875","https://openalex.org/W2104040734","https://openalex.org/W2107235439","https://openalex.org/W2108014552","https://openalex.org/W2108849101","https://openalex.org/W2108964272","https://openalex.org/W2109414252","https://openalex.org/W2109545029","https://openalex.org/W2111717604","https://openalex.org/W2111836627","https://openalex.org/W2113313714","https://openalex.org/W2113938735","https://openalex.org/W2114162691","https://openalex.org/W2114648976","https://openalex.org/W2114951959","https://openalex.org/W2115631255","https://openalex.org/W2115951636","https://openalex.org/W2116830437","https://openalex.org/W2117844639","https://openalex.org/W2118268169","https://openalex.org/W2118443170","https://openalex.org/W2119429726","https://openalex.org/W2119834166","https://openalex.org/W2119991694","https://openalex.org/W2120390079","https://openalex.org/W2121119865","https://openalex.org/W2121597373","https://openalex.org/W2121730416","https://openalex.org/W2121803603","https://openalex.org/W2121807202","https://openalex.org/W2121960829","https://openalex.org/W2122445377","https://openalex.org/W2122586908","https://openalex.org/W2122643628","https://openalex.org/W2122658177","https://openalex.org/W2122939321","https://openalex.org/W2123093300","https://openalex.org/W2123518168","https://openalex.org/W2123987776","https://openalex.org/W2124139886","https://openalex.org/W2126367595","https://openalex.org/W2126618160","https://openalex.org/W2127082380","https://openalex.org/W2128054156","https://openalex.org/W2128648689","https://openalex.org/W2130486201","https://openalex.org/W2131371764","https://openalex.org/W2131632510","https://openalex.org/W2131982022","https://openalex.org/W2133566139","https://openalex.org/W2133765154","https://openalex.org/W2134293291","https://openalex.org/W2134560060","https://openalex.org/W2134728320","https://openalex.org/W2135184862","https://openalex.org/W2136097155","https://openalex.org/W2136219369","https://openalex.org/W2136245823","https://openalex.org/W2136354961","https://openalex.org/W2136749650","https://openalex.org/W2137558988","https://openalex.org/W2139019810","https://openalex.org/W2139104516","https://openalex.org/W2140341972","https://openalex.org/W2141315578","https://openalex.org/W2141885851","https://openalex.org/W2142017607","https://openalex.org/W2142337801","https://openalex.org/W2143071226","https://openalex.org/W2143190437","https://openalex.org/W2143986607","https://openalex.org/W2144120552","https://openalex.org/W2144653878","https://openalex.org/W2145152452","https://openalex.org/W2145271539","https://openalex.org/W2147172932","https://openalex.org/W2148300648","https://openalex.org/W2149264611","https://openalex.org/W2150495335","https://openalex.org/W2151109138","https://openalex.org/W2152532651","https://openalex.org/W2152978188","https://openalex.org/W2152985701","https://openalex.org/W2152994600","https://openalex.org/W2153060237","https://openalex.org/W2153191296","https://openalex.org/W2155013311","https://openalex.org/W2155891427","https://openalex.org/W2155991561","https://openalex.org/W2156177776","https://openalex.org/W2156964052","https://openalex.org/W2157907412","https://openalex.org/W2159346740","https://openalex.org/W2160836190","https://openalex.org/W2161074777","https://openalex.org/W2162102331","https://openalex.org/W2165889558","https://openalex.org/W2166282414","https://openalex.org/W2167012568","https://openalex.org/W2167514234","https://openalex.org/W2168972481","https://openalex.org/W2169969151","https://openalex.org/W2170444093","https://openalex.org/W2170819606","https://openalex.org/W2171720373","https://openalex.org/W2172466148","https://openalex.org/W2181384170","https://openalex.org/W2184646771","https://openalex.org/W2293615862","https://openalex.org/W2329206131","https://openalex.org/W2375635200","https://openalex.org/W2400109762","https://openalex.org/W2402186646","https://openalex.org/W2406934407","https://openalex.org/W2414616395","https://openalex.org/W2419520498","https://openalex.org/W2424169461","https://openalex.org/W2437426290","https://openalex.org/W2465830421","https://openalex.org/W2473433727","https://openalex.org/W2505466152","https://openalex.org/W2792745638","https://openalex.org/W2886978647","https://openalex.org/W4313308953","https://openalex.org/W4313343471"],"related_works":["https://openalex.org/W2035677339","https://openalex.org/W2121119865","https://openalex.org/W2097385117","https://openalex.org/W1159469740","https://openalex.org/W4361291270","https://openalex.org/W144294336","https://openalex.org/W2907245605","https://openalex.org/W2437426290","https://openalex.org/W2084610560","https://openalex.org/W40370008"],"abstract_inverted_index":{"Many":[0],"patients":[1,96],"with":[2,209,217,252],"Behcet\u2019s":[3],"disease":[4,7],"(BD)":[5],"have":[6],"that":[8,35,156],"is":[9,152],"severe":[10],"and":[11,22,53,90,114,117,177,196,223,226,230,244],"do":[12],"not":[13],"respond":[14],"to":[15,44,296],"the":[16,49,61,75,100,140,161,191,218,262,267,275,279,284,291],"conventional":[17],"treatment":[18,34,204,251,292],"of":[19,51,56,77,82,105,125,164,170,184,193,205,270,274,288,293],"systemic":[20],"corticosteroids":[21],"immunosuppressive":[23],"agents.":[24],"Recently,":[25],"IFN-\u03b1":[26,57,83,122,134,149,165,171,238,271,289],"therapy":[27,84,135,150],"has":[28],"shown":[29],"promise":[30],"as":[31],"an":[32,46,78],"effective":[33],"may":[36,157,256],"also":[37],"improve":[38],"long-term":[39],"outcome.":[40],"This":[41],"study":[42],"aims":[43],"provide":[45,257],"insight":[47],"into":[48,74,260],"mechanisms":[50,264,277],"action":[52],"disease-modifying":[54,162,268],"ability":[55,163,269],"by":[58,133,148,237],"focussing":[59],"on":[60,63,112,172],"impact":[62],"T":[64,87,106,144,173,198,232,246],"cell":[65,88,107,199,247],"subsets.":[66],"\\nIn":[67],"this":[68],"study,":[69],"I":[70,187],"describe":[71],"my":[72],"investigation":[73],"effects":[76,169,287],"additional":[79],"6-month":[80],"course":[81],"in":[85,94,136,189,201,215,266,283,290],"modulating":[86],"subsets":[89,200],"their":[91,118],"cytokine":[92],"expression":[93],"BD":[95,294],"ex":[97,219],"vivo":[98,220],"over":[99],"first":[101],"12":[102],"months.":[103],"Investigation":[104],"responses":[108,192],"confirms":[109],"previous":[110],"findings":[111,212],"Th1":[113],"Th2":[115],"cells":[116,127,130,145,233],"associated":[119],"cytokines":[120],"following":[121,203,250],"treatment.":[123,166,185,239],"Analysis":[124],"Th17":[126,176],"shows":[128],"these":[129],"are":[131,146,213,234,248],"downregulated":[132],"peripheral":[137],"blood.":[138],"On":[139],"other":[141],"hand,":[142],"Foxp3+":[143],"upregulated":[147],"which":[151],"a":[153],"novel":[154],"mechanism":[155],"contribute":[158],"substantially":[159],"towards":[160],"Notably,":[167],"most":[168,280],"cells,":[174,179],"including":[175],"Treg":[178],"persist":[180],"even":[181],"after":[182],"cessation":[183],"\\nAlso,":[186],"report":[188],"details":[190],"CD4+,":[194,242],"CD8+":[195,231,243],"\u03b3\u03b4":[197,245],"vitro":[202],"healthy":[206],"donor":[207],"PBMCs":[208],"IFN-\u03b1.":[210,253],"The":[211],"largely":[214],"agreement":[216],"study.":[221],"Fopx3-expressing":[222],"IFN-\u03b3-,":[224],"IL-10-,":[225],"TGF-\u03b2-":[227],"producing":[228],"CD4+":[229],"all":[235],"increased":[236],"Whereas,":[240],"IL-17-producing":[241],"decreased":[249],"\\nOur":[254],"data":[255],"new":[258],"inroads":[259],"elucidating":[261],"immunomodulatory":[263],"involved":[265],"therapy.":[272],"Which":[273],"above":[276],"plays":[278],"important":[281],"role":[282],"observed":[285],"beneficial":[286],"remains":[295],"be":[297],"elucidated.":[298]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}