{"id":"https://openalex.org/W1661990305","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","title":"Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.","display_name":"Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W1661990305","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","mag":"1661990305","pmid":"https://pubmed.ncbi.nlm.nih.gov/23825909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696711"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2696823","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067632638","display_name":"Salih Gencer","orcid":"https://orcid.org/0000-0002-7412-5610","observed_orcids":["https://orcid.org/0000-0002-7412-5610"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]},{"id":"https://openalex.org/I32462889","display_name":"Fatih University","ror":"https://ror.org/02wbrth70","country_code":"TR","type":"education","lineage":["https://openalex.org/I32462889","https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Salih Gencer","raw_affiliation_strings":["Department of Genetics and Bioengineering, Faculty of Engineering, Fatih University, Istanbul 34500, Turkey; ; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul 34662, Turkey;","Department of Genetics and Bioengineering, Faculty of Engineering, Fatih University, Istanbul 34500, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Bioengineering, Faculty of Engineering, Fatih University, Istanbul 34500, Turkey; ; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul 34662, Turkey;","institution_ids":["https://openalex.org/I1281256770","https://openalex.org/I32462889"]},{"raw_affiliation_string":"Department of Genetics and Bioengineering, Faculty of Engineering, Fatih University, Istanbul 34500, Turkey","institution_ids":["https://openalex.org/I32462889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085783658","display_name":"An\u0131l Cebeci","orcid":"https://orcid.org/0000-0001-6493-7714","observed_orcids":["https://orcid.org/0000-0001-6493-7714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil Cebeci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025487536","display_name":"Meliha Burcu Irmak-Yazicioglu","orcid":"https://orcid.org/0000-0002-1651-305X","observed_orcids":["https://orcid.org/0000-0002-1651-305X"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meliha Burcu Irmak-Yazicioglu","raw_affiliation_strings":["Department of Molecular Biology and Genetics Faculty of Engineering and Natural Sciences Uskudar University Istanbul 34662 Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics Faculty of Engineering and Natural Sciences Uskudar University Istanbul 34662 Turkey","institution_ids":["https://openalex.org/I1281256770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8438,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.6957192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"322","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9580000042915344},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.875},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.6150000095367432},{"id":"https://openalex.org/keywords/mmp-7","display_name":"MMP-7","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mmp-15","display_name":"MMP-15","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mmp-17","display_name":"MMP-17","score":0.890999972820282},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mkn45-cells","display_name":"MKN45 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.832444429397583},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.805473804473877},{"id":"https://openalex.org/C2776992468","wikidata":"https://www.wikidata.org/wiki/Q15410860","display_name":"Caffeic acid phenethyl ester","level":4,"score":0.5998207926750183},{"id":"https://openalex.org/C2779964046","wikidata":"https://www.wikidata.org/wiki/Q209286","display_name":"Dichlorofluorescein","level":3,"score":0.5832469463348389},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5067442059516907},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4904317557811737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4671100378036499},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4554736614227295},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4357350468635559},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4087044596672058},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37381958961486816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3487352430820465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2497219443321228},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.11298450827598572},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1082400381565094},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.08651149272918701}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2696823","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23825909","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23825909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese journal of cancer research = Chung-kuo yen cheng yen chiu","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3696711","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3696711/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chin J Cancer Res","raw_type":"Text"},{"id":"mag:1661990305","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23825909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3142011457","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85190X/201303/46599279.html","pdf_url":null,"source":{"id":"https://openalex.org/S26659863","display_name":"Chinese Journal of Cancer Research","issn_l":"1000-9604","issn":["1000-9604","1993-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","oarl","poland-100"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u764c\u75c7\u7814\u7a76\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2696823","doi":"https://doi.org/10.3978/j.issn.1000-9604.2013.06.05","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3696711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W335422122","https://openalex.org/W1543746024","https://openalex.org/W1597643123","https://openalex.org/W1604141668","https://openalex.org/W1666161893","https://openalex.org/W1800142641","https://openalex.org/W1934775191","https://openalex.org/W1943317391","https://openalex.org/W1964677239","https://openalex.org/W1965037168","https://openalex.org/W1966417240","https://openalex.org/W1968837172","https://openalex.org/W1981712944","https://openalex.org/W1987857240","https://openalex.org/W1992595726","https://openalex.org/W1998091047","https://openalex.org/W1998305917","https://openalex.org/W2005088732","https://openalex.org/W2009102003","https://openalex.org/W2014624927","https://openalex.org/W2015536677","https://openalex.org/W2018654729","https://openalex.org/W2018740966","https://openalex.org/W2021454695","https://openalex.org/W2033715673","https://openalex.org/W2034224169","https://openalex.org/W2045338351","https://openalex.org/W2051214291","https://openalex.org/W2064696266","https://openalex.org/W2068982039","https://openalex.org/W2093920639","https://openalex.org/W2094050302","https://openalex.org/W2094156327","https://openalex.org/W2095521656","https://openalex.org/W2102472842","https://openalex.org/W2107235611","https://openalex.org/W2122915617","https://openalex.org/W2125063590","https://openalex.org/W2129729644","https://openalex.org/W2139885850","https://openalex.org/W2169819365","https://openalex.org/W2412365627"],"related_works":["https://openalex.org/W2999746339","https://openalex.org/W2412365627","https://openalex.org/W7056247186","https://openalex.org/W1666161893","https://openalex.org/W3210608186","https://openalex.org/W7131090520","https://openalex.org/W2914485225","https://openalex.org/W2986670247","https://openalex.org/W4366292802","https://openalex.org/W1992183262"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Oxidative":[1],"stress":[2,36,85,106,157,215],"is":[3,206],"linked":[4],"to":[5,27,103,242,246],"increased":[6,172,218],"risk":[7],"of":[8,22,31,34,54,110,119,131,146,154,164,167,189,193,213,220,236],"gastric":[9,23,39,225,239],"cancer":[10,40,226],"and":[11,20,42,67,107,113,137,142,216,228],"matrix":[12],"metalloproteinases":[13],"(MMPs)":[14],"are":[15],"important":[16],"in":[17,37,74,86,139,148,159,161,191,223,238],"the":[18,29,32,38,51,75,87,108,117,120,144,155,162,169,194,211,217,224],"invasion":[19],"metastasis":[21],"cancer.":[24],"We":[25],"aimed":[26],"analyze":[28],"effect":[30],"accumulation":[33,212],"oxidative":[35,84,105,156,214,247],"MKN-45":[41,140],"23132/87":[43,149],"cells":[44,76,89,141,150,227],"following":[45,197],"hydrogen":[46],"peroxide":[47],"(H2O2)":[48],"exposure":[49,112,245],"on":[50,116],"expression":[52,145,190],"patterns":[53],"MMP-1,":[55,132],"MMP-3,":[56],"MMP-7,":[57,133],"MMP-9,":[58],"MMP-10,":[59],"MMP-11,":[60],"MMP-12,":[61],"MMP-14,":[62,134],"MMP-15,":[63,135],"MMP-17,":[64],"MMP-23,":[65],"MMP-28,":[66],"\u03b2-catenin":[68,138],"genes.":[69],"METHODS:":[70],"The":[71,129],"mRNA":[72],"transcripts":[73],"were":[77,122,151,171],"determined":[78],"by":[79,92,124],"RT-PCR.":[80],"Following":[81],"H2O2":[82,111,174],"exposure,":[83],"viable":[88],"was":[90,101],"analyzed":[91],"2',7'-dichlorofluorescein":[93],"diacetate":[94],"(DCFH-DA).":[95],"Caffeic":[96],"acid":[97],"phenethyl":[98],"ester":[99],"(CAPE)":[100],"used":[102],"eliminate":[104],"consequence":[109],"its":[114,243],"removal":[115],"expressions":[118,130,163,170,219],"genes":[121,166,182,222],"evaluated":[123],"quantitative":[125],"real-time":[126],"PCR.":[127],"RESULTS:":[128],"MMP-17":[136],"only":[143],"MMP-15":[147],"increased.":[152],"Removal":[153],"resulted":[158],"decrease":[160],"MMP":[165,221],"which":[168],"after":[173],"exposure.":[175],"\u03b2-catenin,":[176],"a":[177,207],"transcription":[178],"factor":[179],"for":[180],"many":[181],"including":[183],"MMPs,":[184],"also":[185],"displayed":[186],"decreased":[187],"levels":[188],"both":[192],"cell":[195],"lines":[196],"CAPE":[198],"treatment.":[199],"CONCLUSIONS:":[200],"Our":[201],"data":[202],"suggest":[203],"that":[204],"there":[205],"remarkable":[208],"link":[209],"between":[210],"MMPs":[229],"should":[230],"be":[231],"considered":[232],"as":[233],"potential":[234],"targets":[235],"therapy":[237],"cancers":[240],"due":[241],"continuous":[244],"stress.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
