{"id":"https://openalex.org/W1661968451","doi":"https://doi.org/10.1016/s0021-9258(19)63808-1","title":"Physical and Chemical Studies on Ceruloplasmin","display_name":"Physical and Chemical Studies on Ceruloplasmin","publication_year":1970,"publication_date":"1970-09-01","ids":{"openalex":"https://openalex.org/W1661968451","doi":"https://doi.org/10.1016/s0021-9258(19)63808-1","mag":"1661968451","pmid":"https://pubmed.ncbi.nlm.nih.gov/4322435"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)63808-1","doi":"https://doi.org/10.1016/s0021-9258(19)63808-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)63808-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1661968451"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)63808-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108458738","display_name":"Cornelis J. A. Van den Hamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.J.A. van den Hamer","raw_affiliation_strings":["From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102239227","display_name":"Anatol G. Morell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatol G. Morell","raw_affiliation_strings":["From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071983021","display_name":"I. Herbert Scheinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Herbert Scheinberg","raw_affiliation_strings":["From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023530360","display_name":"Jean W. Hickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Hickman","raw_affiliation_strings":["From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038187266","display_name":"Gilbert Ashwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert Ashwell","raw_affiliation_strings":["From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.344,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.92647702,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"245","issue":"17","first_page":"4397","last_page":"4402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":1.0},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.8309999704360962},{"id":"https://openalex.org/keywords/desialylation","display_name":"desialylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neuraminidase","display_name":"neuraminidase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/plasma-clearance","display_name":"plasma clearance","score":0.6359999775886536},{"id":"https://openalex.org/keywords/galactosyl-residues","display_name":"galactosyl residues","score":0.675000011920929},{"id":"https://openalex.org/keywords/tritium-labeling","display_name":"tritium labeling","score":0.953000009059906},{"id":"https://openalex.org/keywords/poisson-distribution","display_name":"Poisson distribution","score":0.8299999833106995},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.9152555465698242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5162803530693054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4348777234554291}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003016","descriptor_name":"Clostridium perfringens","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)63808-1","doi":"https://doi.org/10.1016/s0021-9258(19)63808-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)63808-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4322435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4322435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)63808-1","doi":"https://doi.org/10.1016/s0021-9258(19)63808-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)63808-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W130687650","https://openalex.org/W172341890","https://openalex.org/W186466068","https://openalex.org/W1482449864","https://openalex.org/W1551383822","https://openalex.org/W1569670216","https://openalex.org/W1580023435","https://openalex.org/W1601731316","https://openalex.org/W1970869190","https://openalex.org/W2052517289","https://openalex.org/W2291937974","https://openalex.org/W4242943672"],"related_works":["https://openalex.org/W1569589672","https://openalex.org/W10262643","https://openalex.org/W1566087596","https://openalex.org/W2066839927","https://openalex.org/W2007086886","https://openalex.org/W1979823340","https://openalex.org/W1999339495","https://openalex.org/W1503132859","https://openalex.org/W2003343140","https://openalex.org/W1977699092"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"survival":[2,149],"time":[3],"in":[4,18,40,102,153],"plasma":[5],"of":[6,22,26,34,47,51,57,63,74,87,93,96,108,131,140,150],"incompletely":[7],"desialylated":[8],"ceruloplasmin,":[9],"labeled":[10],"with":[11,14,31,146],"64Cu":[12],"or":[13],"tritium,":[15],"was":[16],"studied":[17],"the":[19,27,35,41,45,52,58,64,69,72,90,94,97,109,121,129,147,154],"rat.":[20],"Removal":[21],"less":[23],"than":[24,49,77],"20%":[25],"terminal":[28],"sialic":[29,117,134],"acid,":[30],"consequent":[32],"exposure":[33,73],"penultimate":[36],"galactosyl":[37,79],"residues,":[38,119],"resulted":[39],"rapid":[42],"disappearance":[43],"from":[44,89,123,137],"circulation":[46],"more":[48,76],"50%":[50],"injected":[53],"dose.":[54],"Statistical":[55],"analysis":[56],"experimental":[59],"results":[60,122],"by":[61],"means":[62],"Poisson":[65],"distribution":[66],"equation":[67],"supports":[68],"estimate":[70],"that":[71,106,151],"no":[75],"2":[78,133],"residues":[80,136],"is":[81],"sufficient":[82],"to":[83,143],"effect":[84],"prompt":[85],"clearance":[86],"ceruloplasmin":[88,141],"circulation.":[91,155],"Examination":[92],"specificity":[95],"two":[98],"neuraminidase":[99],"preparations":[100],"used":[101],"this":[103],"study":[104],"revealed":[105],"each":[107,124],"enzymes":[110],"possessed":[111],"a":[112],"preferential":[113],"affinity":[114],"for":[115],"different":[116],"acid":[118,135],"although":[120],"were":[125],"statistically":[126],"predictable.":[127],"Consequently,":[128],"removal":[130],"any":[132],"1":[138],"molecule":[139,152],"appears":[142],"be":[144],"incompatible":[145],"continued":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}