{"id":"https://openalex.org/W1661881730","doi":null,"title":"Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin.","display_name":"Lipid peroxidation and deformability of red blood cells in experimental sepsis in rats: The protective effects of melatonin.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1661881730","mag":"1661881730","pmid":"https://pubmed.ncbi.nlm.nih.gov/15004332"},"language":"en","primary_location":{"id":"pmid:15004332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15004332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056922021","display_name":"M\u00fckerrem Bet\u00fcl Yerer","orcid":"https://orcid.org/0000-0002-4503-8032","observed_orcids":["https://orcid.org/0000-0002-4503-8032"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M Betul Yerer","raw_affiliation_strings":["Faculty of Medicine, Department of Physiology, University of Erciyes, Kayseri, Turkey. eczbetul@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Physiology, University of Erciyes, Kayseri, Turkey. eczbetul@yahoo.com","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109979994","display_name":"Hande Yap\u0131\u015flar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hande Yapislar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056947207","display_name":"Sami Aydo\u011fan","orcid":"https://orcid.org/0000-0003-3230-5864","observed_orcids":["https://orcid.org/0000-0003-3230-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sami Aydogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032309855","display_name":"\u00d6zlem Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0001-5547-6653","observed_orcids":["https://orcid.org/0000-0001-5547-6653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ozlem Yalcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103355048","display_name":"Oguz Kerim Baskurt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oguz Baskurt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0054,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.70378263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"30","issue":"2","first_page":"77","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.5214999914169312,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.21080000698566437,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.1331000030040741,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.7519999742507935},{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9279999732971191},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7950000166893005},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9490000009536743},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nitric-oxide-scavenging","display_name":"nitric oxide scavenging","score":0.8659999966621399},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.9186033010482788},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.8183732032775879},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7664862275123596},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7307438254356384},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6945526003837585},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5670281648635864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5563306212425232},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5386028289794922},{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.5222650170326233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5178694725036621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4771508574485779},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.46577733755111694},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41234228014945984},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3220391869544983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3056546449661255},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.295024037361145}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15004332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15004332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"},{"id":"mag:1661881730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15004332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W180782870","https://openalex.org/W314545307","https://openalex.org/W866173586","https://openalex.org/W1538399032","https://openalex.org/W1971060562","https://openalex.org/W1972414271","https://openalex.org/W1984233405","https://openalex.org/W2012530098","https://openalex.org/W2013156866","https://openalex.org/W2062708982","https://openalex.org/W2065699321","https://openalex.org/W2083631490","https://openalex.org/W2121045276","https://openalex.org/W2122485299","https://openalex.org/W2407137910","https://openalex.org/W3216624875"],"related_works":["https://openalex.org/W4298890841","https://openalex.org/W1593625319","https://openalex.org/W2000184770","https://openalex.org/W4292821615","https://openalex.org/W155312458","https://openalex.org/W4313340390","https://openalex.org/W1992507257","https://openalex.org/W4361801273","https://openalex.org/W4401352799","https://openalex.org/W3048878698"],"abstract_inverted_index":{"Sepsis":[0],"has":[1],"been":[2],"associated":[3],"with":[4,132],"a":[5,19,27,42],"lipopolysaccharide":[6],"(LPS)":[7],"induced":[8],"bacterial":[9],"infection":[10],"and":[11,15,50,79,102,135,239],"causes":[12],"biochemical,":[13],"hemodynamic":[14],"physiological":[16],"alterations":[17],"in":[18,37,54,64,118,122,154,169,197,229],"system.":[20],"Erythrocyte":[21],"deformability":[22,51,202],"is":[23],"very":[24],"critical":[25],"for":[26],"microcirculatory":[28],"system":[29],"to":[30,124,184,233],"function":[31],"effectively.":[32],"Hence,":[33],"we":[34],"were":[35,62,83,166,176,195],"interested":[36],"examining":[38],"the":[39,77,80,111,119,163,170,173,179,192,201,216,227],"effects":[40],"of":[41,52,70,110,189],"potent":[43],"antioxidant,":[44],"melatonin":[45],"(Mel),":[46],"on":[47],"lipid":[48,190,206,245],"peroxidation":[49,207],"eythrocytes":[53],"LPS-induced":[55],"experimental":[56,230],"sepsis.":[57],"Male":[58],"Swiss":[59],"Albino":[60],"rats":[61],"used":[63],"6":[65],"groups,":[66],"each":[67],"group":[68,75,121,172],"comprising":[69],"10":[71],"animals.":[72],"The":[73],"first":[74],"was":[76,130,138,151,160,203,208,218],"control,":[78],"other":[81,126],"groups":[82,199],"administered":[84],"LPS":[85,93,101,105,120,198],"(10":[86,90],"mg/kg,":[87,91],"i.p.),":[88,92,98],"Mel":[89,99,103,147,171,211],"+":[94,100,104,106],"L-NAME":[95,134,145,213],"(5":[96],"mM,":[97],"L-NAME,":[107],"respectively.":[108],"Deformability":[109],"RBCs":[112],"decreased":[113],"significantly":[114],"(p":[115],"<":[116],"0.05)":[117],"comparison":[123],"all":[125],"groups.":[127],"This":[128,149,205],"reduction":[129],"prevented":[131],"both":[133],"Mel,":[136],"but":[137],"not":[139],"as":[140,142,186,242],"significant":[141],"when":[143,162],"administering":[144],"or":[146],"alone.":[148],"result":[150],"adversely":[152],"seen":[153],"nitric":[155,235],"oxide":[156,236],"levels,":[157],"i.e.":[158],"RBCD":[159,180,217,228],"reduced":[161,177],"NO":[164,174],"levels":[165,175,194],"higher.":[167],"Therefore":[168],"while":[178],"enhanced.":[181,219],"In":[182],"addition":[183],"these,":[185],"an":[187],"index":[188],"peroxidation,":[191],"Malondialdehyde":[193],"elevated":[196],"whereas":[200],"reduced.":[204],"suppressed":[209],"by":[210,244],"and/or":[212],"significantly,":[214],"where":[215],"These":[220],"results":[221],"show":[222],"that,":[223],"Melatonin":[224],"can":[225],"elevate":[226],"sepsis":[231],"due":[232],"its":[234],"scavenging":[237],"activity":[238],"antioxidant":[240],"effect":[241],"revealed":[243],"peroxidation.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
