{"id":"https://openalex.org/W1661847997","doi":"https://doi.org/10.1128/jvi.69.2.814-824.1995","title":"Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication","display_name":"Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W1661847997","doi":"https://doi.org/10.1128/jvi.69.2.814-824.1995","mag":"1661847997","pmid":"https://pubmed.ncbi.nlm.nih.gov/7815548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/188647"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.69.2.814-824.1995","doi":"https://doi.org/10.1128/jvi.69.2.814-824.1995","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.69.2.814-824.1995","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC188647","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015255309","display_name":"Alexander Steinkasserer","orcid":"https://orcid.org/0000-0001-7187-6729","observed_orcids":["https://orcid.org/0000-0001-7187-6729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Steinkasserer","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Harrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Harrison","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038950669","display_name":"Andreas Billich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Billich","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101200","display_name":"F Hammerschmid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Hammerschmid","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068236428","display_name":"Gudrun Werner","orcid":"https://orcid.org/0000-0002-0820-9277","observed_orcids":["https://orcid.org/0000-0002-0820-9277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Werner","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090460450","display_name":"B H Wolff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Wolff","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012157601","display_name":"P. Peichl","orcid":"https://orcid.org/0000-0002-1090-7904","observed_orcids":["https://orcid.org/0000-0002-1090-7904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Peichl","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046094011","display_name":"G. E. Palfi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Palfi","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052948227","display_name":"W. Schnitzel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Schnitzel","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068561612","display_name":"E Mlynar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Mlynar","raw_affiliation_strings":["Sandoz Forschungsinstitut GmbH, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sandoz Forschungsinstitut GmbH, Vienna, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4509,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.94312796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"69","issue":"2","first_page":"814","last_page":"824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6520000100135803},{"id":"https://openalex.org/keywords/preintegration-complex","display_name":"preintegration complex","score":0.7099999785423279},{"id":"https://openalex.org/keywords/viral-dna-integration","display_name":"viral DNA integration","score":0.7170000076293945},{"id":"https://openalex.org/keywords/2-ltr-circles","display_name":"2-LTR circles","score":0.8360000252723694},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.6299999952316284},{"id":"https://openalex.org/keywords/gag-protein","display_name":"Gag protein","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cyclophilin-a","display_name":"cyclophilin A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.4749999940395355},{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase","display_name":"HIV-1 reverse transcriptase","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.5230000019073486},{"id":"https://openalex.org/keywords/hiv-1-rev","display_name":"HIV-1 Rev protein","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7563964128494263},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.7537481784820557},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.7406923174858093},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6288306713104248},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.566092312335968},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5173139572143555},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5089452266693115},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49581179022789},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.4918651580810547},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4646987318992615},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46404096484184265},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4531642496585846},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44063428044319153},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3245829939842224},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27942603826522827},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.272326797246933},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.21776869893074036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1546899974346161},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1354711353778839},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0858575701713562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06971955299377441},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0676271915435791}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011533","descriptor_name":"Proviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014762","descriptor_name":"Viral Interference","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016655","descriptor_name":"HIV Core Protein p24","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.69.2.814-824.1995","doi":"https://doi.org/10.1128/jvi.69.2.814-824.1995","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.69.2.814-824.1995","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:236448","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC188647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:188647","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/188647","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:7815548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7815548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:236448","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC188647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W49920453","https://openalex.org/W301185264","https://openalex.org/W1499503032","https://openalex.org/W1528522073","https://openalex.org/W1539977736","https://openalex.org/W1562075782","https://openalex.org/W1584808499","https://openalex.org/W1753464271","https://openalex.org/W1796915314","https://openalex.org/W1837201208","https://openalex.org/W1932084946","https://openalex.org/W1953417221","https://openalex.org/W1967446284","https://openalex.org/W1972326574","https://openalex.org/W1976129849","https://openalex.org/W1977282539","https://openalex.org/W1985867651","https://openalex.org/W1991670386","https://openalex.org/W2001102430","https://openalex.org/W2001362581","https://openalex.org/W2004803899","https://openalex.org/W2004878760","https://openalex.org/W2005288455","https://openalex.org/W2008791719","https://openalex.org/W2019508559","https://openalex.org/W2034631046","https://openalex.org/W2036890038","https://openalex.org/W2051793369","https://openalex.org/W2058350611","https://openalex.org/W2060333964","https://openalex.org/W2062120260","https://openalex.org/W2062639699","https://openalex.org/W2076634735","https://openalex.org/W2076811542","https://openalex.org/W2077430714","https://openalex.org/W2084278833","https://openalex.org/W2087809591","https://openalex.org/W2088493593","https://openalex.org/W2088851522","https://openalex.org/W2089850443","https://openalex.org/W2093939923","https://openalex.org/W2103368826","https://openalex.org/W2121201612","https://openalex.org/W2139949747","https://openalex.org/W2144634347","https://openalex.org/W2147342198","https://openalex.org/W2157055613","https://openalex.org/W2255773417","https://openalex.org/W2316906870","https://openalex.org/W2330088745","https://openalex.org/W2331893929","https://openalex.org/W2399312126","https://openalex.org/W2409911101","https://openalex.org/W3020963154","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2103368826","https://openalex.org/W1970055162","https://openalex.org/W4251388939","https://openalex.org/W2149227294","https://openalex.org/W2188185325","https://openalex.org/W7100369377","https://openalex.org/W7100961134","https://openalex.org/W7098020169","https://openalex.org/W2118502418","https://openalex.org/W2158685964"],"abstract_inverted_index":{"SDZ":[0,32,71,104,126,150,207,217,266],"NIM":[1,33,72,105,127,151,208,218,267],"811":[2,34,73,128,152],"is":[3,9,35,52,93,162,179,262],"a":[4,158,245,275],"cyclosporin":[5,312,328],"A":[6,329],"analog":[7],"that":[8,258,300],"completely":[10],"devoid":[11],"of":[12,29,31,40,56,101,103,120,125,132,137,146,164,167,197,211,225,237,253,286,292,327],"immunosuppressive":[13],"capacity":[14],"but":[15,281],"exhibits":[16],"potent":[17],"and":[18,61,83,144,231,330],"selective":[19],"anti-human":[20],"immunodeficiency":[21],"virus":[22,121],"type":[23],"1":[24],"(HIV-1)":[25],"activity.":[26],"The":[27,123],"mechanism":[28],"action":[30,102],"clearly":[36],"different":[37],"from":[38,89],"those":[39,236],"all":[41],"other":[42],"anti-HIV":[43],"agents":[44],"described":[45],"so":[46],"far.":[47],"In":[48],"cell-free":[49],"assays,":[50],"it":[51,62,297],"not":[53,64,75,94,277],"an":[54],"inhibitor":[55],"reverse":[57,228],"transcriptase,":[58],"protease,":[59],"integrase,":[60],"does":[63,74],"interfere":[65],"with":[66,315],"Rev":[67],"or":[68,78],"Tat":[69],"function.":[70],"down-regulate":[76],"CD4":[77],"inhibit":[79],"fusion":[80],"between":[81],"infected":[82,221],"uninfected,":[84],"CD4-expressing":[85],"cells.":[86],"p24":[87],"production":[88],"chronically":[90,220],"HIV-infected":[91],"cells":[92,116,222],"impaired":[95,264],"either.":[96],"To":[97],"elucidate":[98],"the":[99,130,182,212,238,259,293,308,320,324],"mode":[100],"811,":[106],"we":[107],"performed":[108],"DNA":[109,134,147,199,202],"PCR":[110],"analysis":[111],"in":[112,117,157,248,279,283],"HIV-1":[113,301],"IIIB-infected":[114],"MT4":[115],"one":[118],"cycle":[119],"replication.":[122],"effects":[124],"on":[129],"kinetics":[131],"viral":[133,191,213,232,287],"synthesis,":[135],"appearance":[136],"two-long":[138],"terminal":[139],"repeat":[140],"circles":[141],"(2-LTR":[142],"circles),":[143],"integration":[145,196],"were":[148],"studied.":[149],"inhibited":[153,205],"2-LTR":[154],"circle":[155],"formation":[156],"concentration-dependent":[159],"manner,":[160],"which":[161,256],"indicative":[163],"nuclear":[165,290],"localization":[166,291],"preintegration":[168,294],"complexes.":[169],"Half-maximal":[170],"inhibition":[171],"was":[172,203,298],"achieved":[173],"at":[174],"0.17":[175],"microgram/ml;":[176],"this":[177],"concentration":[178,252],"close":[180],"to":[181,187,235,273,305],"50%":[183],"inhibitory":[184,251],"concentrations":[185],"(0.01":[186],"0.2":[188],"microgram/ml)":[189,255],"for":[190,311,323],"growth":[192],"inhibition.":[193],"As":[194],"expected,":[195],"proviral":[198],"into":[200],"cellular":[201],"also":[204,263,282],"by":[206,216,265],"811.":[209,268],"Analysis":[210],"particles":[214,243],"produced":[215],"811-treated,":[219],"revealed":[223],"amounts":[224],"capsid":[226],"proteins,":[227],"transcriptase":[229],"activity,":[230],"RNA":[233],"comparable":[234],"untreated":[239],"control.":[240],"However,":[241],"these":[242],"showed":[244],"dose-dependent":[246],"reduction":[247],"infectivity":[249],"(50%":[250],"0.028":[254],"indicates":[257],"assembly":[260,280],"process":[261],"Gag":[269,302],"proteins":[270],"are":[271],"postulated":[272],"play":[274],"role":[276],"only":[278],"early":[284],"steps":[285],"replication,":[288],"e.g.,":[289],"complex.":[295],"Recently,":[296],"reported":[299],"protein":[303],"binds":[304],"cyclophilin":[306],"A,":[307],"intracellular":[309],"receptor":[310],"A.":[313],"Interference":[314],"Gag-cyclophilin":[316],"interaction":[317],"may":[318],"be":[319],"molecular":[321],"basis":[322],"antiviral":[325],"activity":[326],"its":[331],"analogs.":[332]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}