{"id":"https://openalex.org/W1661787331","doi":"https://doi.org/10.4049/jimmunol.173.4.2736","title":"Tolerance Induced by the Lipopeptide Pam3Cys Is Due to Ablation of IL-1R-Associated Kinase-1","display_name":"Tolerance Induced by the Lipopeptide Pam3Cys Is Due to Ablation of IL-1R-Associated Kinase-1","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1661787331","doi":"https://doi.org/10.4049/jimmunol.173.4.2736","mag":"1661787331","pmid":"https://pubmed.ncbi.nlm.nih.gov/15294992"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.173.4.2736","doi":"https://doi.org/10.4049/jimmunol.173.4.2736","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.4.2736","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001108606","display_name":"Maciej Siedlar","orcid":"https://orcid.org/0000-0002-3904-5412","observed_orcids":["https://orcid.org/0000-0002-3904-5412","https://orcid.org/0000-0003-0540-5659"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]},{"id":"https://openalex.org/I4405259207","display_name":"Institut f\u00fcr Immunologie","ror":"https://ror.org/01x8c0495","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Maciej Siedlar","raw_affiliation_strings":["Department of Clinical Immunology, Jagiellonian University Medical College , Krako\u0301w ,","Institute for Immunology, University of Muenchen , Muenchen ,","*Institute for Immunology, University of Muenchen, Muenchen, Germany;","\u2020Department of Clinical Immunology, Jagiellonian University Medical College, Krako\u0301w, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Jagiellonian University Medical College , Krako\u0301w ,","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Institute for Immunology, University of Muenchen , Muenchen ,","institution_ids":["https://openalex.org/I4405259207"]},{"raw_affiliation_string":"*Institute for Immunology, University of Muenchen, Muenchen, Germany;","institution_ids":["https://openalex.org/I4405259207"]},{"raw_affiliation_string":"\u2020Department of Clinical Immunology, Jagiellonian University Medical College, Krako\u0301w, Poland;","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034207468","display_name":"Marion Frankenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marion Frankenberger","raw_affiliation_strings":["Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]},{"raw_affiliation_string":"\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024536620","display_name":"Elke Benkhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]},{"id":"https://openalex.org/I4405259207","display_name":"Institut f\u00fcr Immunologie","ror":"https://ror.org/01x8c0495","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke Benkhart","raw_affiliation_strings":["Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","Institute for Immunology, University of Muenchen , Muenchen ,","*Institute for Immunology, University of Muenchen, Muenchen, Germany;","\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]},{"raw_affiliation_string":"Institute for Immunology, University of Muenchen , Muenchen ,","institution_ids":["https://openalex.org/I4405259207"]},{"raw_affiliation_string":"*Institute for Immunology, University of Muenchen, Muenchen, Germany;","institution_ids":["https://openalex.org/I4405259207"]},{"raw_affiliation_string":"\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069390047","display_name":"Terje Espevik","orcid":"https://orcid.org/0000-0003-0354-5068","observed_orcids":["https://orcid.org/0000-0003-0354-5068"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Terje Espevik","raw_affiliation_strings":["Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter , Trondheim ,","\u00a7Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter, Trondheim, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter , Trondheim ,","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"\u00a7Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter, Trondheim, Norway;","institution_ids":["https://openalex.org/I204778367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035192895","display_name":"Martina Quirling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Quirling","raw_affiliation_strings":["Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t , Mu\u0308nchen ,","\u00b6Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t, Mu\u0308nchen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t , Mu\u0308nchen ,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"\u00b6Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t, Mu\u0308nchen, Germany; and","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026070765","display_name":"Korbinian Brand","orcid":"https://orcid.org/0000-0002-8209-3655","observed_orcids":["https://orcid.org/0000-0002-8209-3655"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Korbinian Brand","raw_affiliation_strings":["Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t , Mu\u0308nchen ,","\u00b6Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t, Mu\u0308nchen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t , Mu\u0308nchen ,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"\u00b6Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universita\u0308t, Mu\u0308nchen, Germany; and","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113597622","display_name":"Marek Zembala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marek Zembala","raw_affiliation_strings":["Department of Clinical Immunology, Jagiellonian University Medical College , Krako\u0301w ,","\u2020Department of Clinical Immunology, Jagiellonian University Medical College, Krako\u0301w, Poland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology, Jagiellonian University Medical College , Krako\u0301w ,","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"\u2020Department of Clinical Immunology, Jagiellonian University Medical College, Krako\u0301w, Poland;","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057239405","display_name":"Loems Ziegler\u2010Heitbrock","orcid":"https://orcid.org/0000-0003-1477-6689","observed_orcids":["https://orcid.org/0000-0003-1477-6689"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Loems Ziegler-Heitbrock","raw_affiliation_strings":["Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","Department of Microbiology and Immunology, University of Leicester , Leicester ,","\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;","\u2225Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting) , Gauting ,","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Leicester , Leicester ,","institution_ids":["https://openalex.org/I153648349"]},{"raw_affiliation_string":"\u2021Clinical Cooperation Group \u201cInflammatory Lung Diseases\u201d (Institute for Inhalation Biology, GSF National Research Center and Asklepios Fachkliniken, Mu\u0308nchen-Gauting), Gauting, Germany;","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125421"]},{"raw_affiliation_string":"\u2225Department of Microbiology and Immunology, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.363,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.92428646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"173","issue":"4","first_page":"2736","last_page":"2745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.6370000243186951},{"id":"https://openalex.org/keywords/irak1","display_name":"IRAK1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tolerance-pharmacology-and-immunology","display_name":"tolerance (pharmacology and immunology)","score":0.41100001335144043},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tnf-gene-expression","display_name":"TNF gene expression","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mono-mac-6-cells","display_name":"Mono Mac 6 cells","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.6197772026062012},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5797749757766724},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5305571556091309},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5176182985305786},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.5116403698921204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49214881658554077},{"id":"https://openalex.org/C2777425210","wikidata":"https://www.wikidata.org/wiki/Q2903964","display_name":"Lipopeptide","level":3,"score":0.4911195933818817},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4840478301048279},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4158868193626404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37940308451652527},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36870622634887695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33204299211502075},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3067634701728821},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.1385718286037445},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08393102884292603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07085925340652466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053592","descriptor_name":"Interleukin-1 Receptor-Associated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4049/jimmunol.173.4.2736","doi":"https://doi.org/10.4049/jimmunol.173.4.2736","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.4.2736","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15294992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15294992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1332376","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1332376","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:4108","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=4108","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J. Immunol. 173, 2736-2745 (2004)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1513486408","https://openalex.org/W1533876739","https://openalex.org/W1549853453","https://openalex.org/W1580600824","https://openalex.org/W1596708757","https://openalex.org/W1604970632","https://openalex.org/W1932149655","https://openalex.org/W1945510071","https://openalex.org/W1953329867","https://openalex.org/W1968336033","https://openalex.org/W1969941746","https://openalex.org/W1971533272","https://openalex.org/W1972739692","https://openalex.org/W1988059334","https://openalex.org/W1988296387","https://openalex.org/W1993243592","https://openalex.org/W1994169091","https://openalex.org/W2004773897","https://openalex.org/W2005047699","https://openalex.org/W2006660114","https://openalex.org/W2013994536","https://openalex.org/W2016862474","https://openalex.org/W2024803597","https://openalex.org/W2027042806","https://openalex.org/W2028012301","https://openalex.org/W2035217892","https://openalex.org/W2043981380","https://openalex.org/W2044153851","https://openalex.org/W2047822772","https://openalex.org/W2052637669","https://openalex.org/W2053043145","https://openalex.org/W2068312705","https://openalex.org/W2071562414","https://openalex.org/W2077296632","https://openalex.org/W2096678608","https://openalex.org/W2098387574","https://openalex.org/W2100719344","https://openalex.org/W2104942758","https://openalex.org/W2105415988","https://openalex.org/W2110101961","https://openalex.org/W2114347295","https://openalex.org/W2115893060","https://openalex.org/W2116422482","https://openalex.org/W2127642399","https://openalex.org/W2130871739","https://openalex.org/W2131541472","https://openalex.org/W2141150979","https://openalex.org/W2143300196","https://openalex.org/W2145110660","https://openalex.org/W2145584783","https://openalex.org/W2145803213","https://openalex.org/W2148579227","https://openalex.org/W2148694689","https://openalex.org/W2149872736","https://openalex.org/W2149999204","https://openalex.org/W2151120686","https://openalex.org/W2157856503","https://openalex.org/W2166638847","https://openalex.org/W2167715503","https://openalex.org/W2182730598","https://openalex.org/W2398743646","https://openalex.org/W2408979431","https://openalex.org/W4248219898","https://openalex.org/W4312920885"],"related_works":["https://openalex.org/W641902197","https://openalex.org/W2899821611","https://openalex.org/W1533876739","https://openalex.org/W2157856503","https://openalex.org/W4313354681","https://openalex.org/W2016623432","https://openalex.org/W1953329867","https://openalex.org/W2035217892","https://openalex.org/W2131541472","https://openalex.org/W2069686651"],"abstract_inverted_index":{"Stimulation":[0],"of":[1,24,33,74,82,167],"the":[2,11,25,34,56,72,75,83,171,177],"human":[3],"monocytic":[4,164],"cell":[5],"line":[6],"Mono":[7,161],"Mac":[8,162],"6":[9,163],"with":[10,36,49,132],"synthetic":[12],"lipopeptide":[13],"(S)-(2,3-bis(palmitoyloxy)-(2RS)-propyl)-N-palmitoyl-(R)-Cys-(S)-Ser(S)-Lys(4)-OH,":[14],"trihydrochloride":[15],"(Pam(3)Cys)":[16],"at":[17,38,51,129,170],"10":[18,52],"microg/ml":[19,40],"induces":[20],"a":[21,29,43,90],"rapid":[22],"expression":[23,67,169],"TNF":[26],"gene":[27],"in":[28,86,120,137,160],"TLR2-dependent":[30],"fashion.":[31],"Preculture":[32],"cells":[35,57,88,102],"Pam(3)Cys":[37,50],"1":[39],"leads":[41],"to":[42,61,92],"reduced":[44],"response":[45],"after":[46],"subsequent":[47],"stimulation":[48],"microg/ml,":[53],"indicating":[54],"that":[55,159],"have":[58],"become":[59],"tolerant":[60,76],"Pam(3)Cys.":[62],"The":[63],"CD14":[64],"and":[65,151,173],"TLR2":[66],"is":[68,157,176],"not":[69,186],"decreased":[70],"on":[71],"surface":[73],"cells,":[77,139,165],"but":[78,110,185],"rather":[79],"up-regulated.":[80],"Analysis":[81],"NF-kappaB":[84],"binding":[85],"Pam(3)Cys-tolerant":[87,101],"shows":[89],"failure":[91],"mobilize":[93],"NF-kappaB-p50p65":[94],"heterodimers,":[95],"while":[96,123],"NF-kappaB-p50p50":[97],"homodimers":[98,141],"remain":[99],"unchanged.":[100],"showed":[103],"neither":[104],"IkappaBalpha-Ser(32)":[105],"phosphorylation":[106],"nor":[107],"IkappaBalpha":[108],"degradation":[109],"MyD88":[111],"protein":[112,117,145,174],"was":[113,118,126,147],"unaltered.":[114],"However,":[115],"IRAK-1":[116,124,144,168],"absent":[119],"Pam(3)Cys-induced":[121,183],"tolerance,":[122,184],"mRNA":[125,172],"still":[127],"detectable":[128],"30%":[130],"compared":[131],"untreated":[133],"cells.":[134],"In":[135],"contrast,":[136],"LPS-tolerized":[138],"p50p50":[140],"were":[142],"induced,":[143],"level":[146],"only":[148],"partially":[149],"decreased,":[150],"p50p65":[152],"mobilization":[153],"remained":[154],"intact.":[155],"It":[156],"concluded":[158],"inhibition":[166],"levels":[175],"main":[178],"TLR-2-dependent":[179],"mechanism":[180],"responsible":[181],"for":[182,187],"TLR-4-dependent":[188],"LPS-induced":[189],"tolerance.":[190]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}