{"id":"https://openalex.org/W166108348","doi":null,"title":"Association between genetic variants in glutathione peroxidase 1 (GPx1) gene, GPx activity and the risk of prostate cancer.","display_name":"Association between genetic variants in glutathione peroxidase 1 (GPx1) gene, GPx activity and the risk of prostate cancer.","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W166108348","mag":"166108348","pmid":"https://pubmed.ncbi.nlm.nih.gov/21993316"},"language":"en","primary_location":{"id":"pmid:21993316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21993316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva urologica e nefrologica = The Italian journal of urology and nephrology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021732420","display_name":"Canan K\u00fc\u00e7\u00fckgergin","orcid":"https://orcid.org/0000-0002-1797-5889","observed_orcids":["https://orcid.org/0000-0002-1797-5889"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"C Kucukgergin","raw_affiliation_strings":["Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034989675","display_name":"Murat G\u00f6kp\u0131nar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gokpinar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"O Sanli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Sanli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013451018","display_name":"Tzevat Tefik","orcid":"https://orcid.org/0000-0002-1398-8332","observed_orcids":["https://orcid.org/0000-0002-1398-8332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tefik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072021189","display_name":"Tayfun Oktar","orcid":"https://orcid.org/0000-0001-7719-2440","observed_orcids":["https://orcid.org/0000-0001-7719-2440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Oktar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113659631","display_name":"\u015eule Se\u00e7kin","orcid":"https://orcid.org/0000-0002-5496-4169","observed_orcids":["https://orcid.org/0000-0002-5496-4169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Seckin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2972,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.77543933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"63","issue":"3","first_page":"183","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.843999981880188},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.6890000104904175},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5559999942779541},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4880000054836273},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C203663253","wikidata":"https://www.wikidata.org/wiki/Q18026456","display_name":"GPX1","level":5,"score":0.8456848859786987},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7431758046150208},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6721867322921753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.64835524559021},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6059452295303345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5872141718864441},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.555658221244812},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.4452741742134094},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.4399094879627228},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41924482583999634},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.41592204570770264},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3008057475090027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24893000721931458},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.22278186678886414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18603774905204773},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14017653465270996},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.09634828567504883},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000094765","descriptor_name":"Glutathione Peroxidase GPX1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21993316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21993316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva urologica e nefrologica = The Italian journal of urology and nephrology","raw_type":"Journal Article"},{"id":"mag:166108348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21993316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8899999856948853}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2157906373","https://openalex.org/W2062014265","https://openalex.org/W2012628516","https://openalex.org/W2033955712","https://openalex.org/W3033072903","https://openalex.org/W2042477766","https://openalex.org/W4243756007","https://openalex.org/W2015407291","https://openalex.org/W2143131987","https://openalex.org/W1974449179"],"abstract_inverted_index":{"AIM:":[0],"The":[1,149,212],"aim":[2],"of":[3,20,39,132,147,182,200,229],"this":[4,34,67,209],"study":[5],"was":[6,100,115,152,171,194],"to":[7,117,129,166],"investigate":[8],"the":[9,16,130,137,190,225,236],"association":[10],"between":[11],"GPx1":[12,97,218,238],"Pro198Leu":[13,98,219,239],"polymorphism":[14,99,110,220,240],"with":[15,48,136,154,176,197,224],"development":[17,226],"and":[18,24,29,43,57,80,83,90,122,161,227,231,241],"progression":[19,228],"prostate":[21,50],"cancer":[22],"(PCa)":[23],"evaluate":[25],"whether":[26],"smoking":[27,205],"status":[28],"advanced":[30],"age":[31],"could":[32],"modify":[33],"association.":[35,210],"METHODS:":[36],"A":[37],"total":[38],"134":[40],"PCa":[41,162,201,230],"patients":[42,72,175],"159":[44],"healthy":[45],"control":[46],"subjects":[47,135],"serum":[49],"specific":[51],"antigen":[52],"(PSA)":[53],"levels":[54],"<4":[55],"ng/mL":[56],"normal":[58],"digital":[59],"rectal":[60],"examination":[61],"(DRE)":[62],"findings":[63],"were":[64,73],"enrolled":[65],"in":[66,174,202],"prospectively":[68],"designed":[69],"study.":[70],"PCA":[71],"classified":[74],"as":[75],"low":[76,183],"(T1":[77],"or":[78,88,92,94,141],"T2":[79],"N0M0":[81,91],"stages)":[82],"high":[84,177],"stage":[85,178,184],"disease":[86,179],"(T3":[87],"T4":[89],"N1":[93],"M1":[95],"stages).":[96],"determined":[101],"using":[102],"polymerase":[103],"chain":[104],"reaction":[105],"(PCR)":[106],"restriction":[107],"fragment":[108],"length":[109],"(RFLP).":[111],"Logistic":[112],"regression":[113],"analysis":[114],"used":[116],"estimate":[118],"odds":[119],"ratios":[120],"(OR)":[121],"95%":[123],"confidence":[124],"intervals":[125],"(95%CI).":[126],"RESULTS:":[127],"Compared":[128],"carriers":[131],"Pro/Pro":[133],"genotype,":[134],"variant":[138,191],"genotypes":[139],"(Pro/Leu":[140],"Leu/Leu)":[142],"had":[143],"significantly":[144,195],"higher":[145],"risk":[146,199],"PCa.":[148,242],"Leu/Leu":[150,169,192],"genotype":[151,170,193],"correlated":[153],"lower":[155],"GPx":[156],"activity":[157],"among":[158],"both":[159],"controls":[160],"patients.":[163],"With":[164],"respect":[165],"tumor":[167],"stage,":[168],"more":[172],"frequent":[173],"than":[180],"those":[181],"disease.":[185],"In":[186],"stratified":[187],"analyses,":[188],"although":[189],"associated":[196,223],"increased":[198],"older":[203,232],"age,":[204],"did":[206],"not":[207],"alter":[208],"CONCLUSION:":[211],"present":[213],"data":[214],"provide":[215],"evidence":[216],"that":[217],"may":[221,234],"be":[222],"ages":[233],"influence":[235],"association.between":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}