{"id":"https://openalex.org/W166076404","doi":null,"title":"The composite nodule. A structural and functional unit of the reactive human lymph node.","display_name":"The composite nodule. A structural and functional unit of the reactive human lymph node.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W166076404","mag":"166076404","pmid":"https://pubmed.ncbi.nlm.nih.gov/2934988","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888128"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888128","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026184070","display_name":"van den Oord Jj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J van den Oord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112216682","display_name":"Ch. De Wolf-Peeters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C de Wolf-Peeters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052259203","display_name":"Desmet Vj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V J Desmet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.292,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.79575227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"122","issue":"1","first_page":"83","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13314","display_name":"Lymphadenopathy Diagnosis and Analysis","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-lymph-nodes","display_name":"reactive lymph nodes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.652999997138977},{"id":"https://openalex.org/keywords/interdigitating-reticulum-cells","display_name":"interdigitating reticulum cells","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dendritic-reticulum-cells","display_name":"dendritic reticulum cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/high-endothelial-venules","display_name":"high endothelial venules","score":0.8980000019073486},{"id":"https://openalex.org/keywords/follicular-hyperplasia","display_name":"follicular hyperplasia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/white-pulp","display_name":"white pulp","score":0.5569999814033508},{"id":"https://openalex.org/keywords/plasma-cell-maturation","display_name":"plasma cell maturation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/lymph-node-architecture","display_name":"lymph node architecture","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2778232189","wikidata":"https://www.wikidata.org/wiki/Q626936","display_name":"White pulp","level":3,"score":0.7493826746940613},{"id":"https://openalex.org/C2780385752","wikidata":"https://www.wikidata.org/wiki/Q637997","display_name":"High endothelial venules","level":3,"score":0.6540838479995728},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5942512154579163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5853680372238159},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.5379137992858887},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5027046203613281},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.4926665425300598},{"id":"https://openalex.org/C3753494","wikidata":"https://www.wikidata.org/wiki/Q2631550","display_name":"Follicular dendritic cells","level":5,"score":0.49184703826904297},{"id":"https://openalex.org/C2908591792","wikidata":"https://www.wikidata.org/wiki/Q16999269","display_name":"Follicular hyperplasia","level":3,"score":0.4886498749256134},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4116394817829132},{"id":"https://openalex.org/C142579037","wikidata":"https://www.wikidata.org/wiki/Q767749","display_name":"Reticulum","level":3,"score":0.4101811945438385},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.3752017617225647},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.3731815814971924},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3235727548599243},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30479755997657776},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.2799507677555084},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2683600187301636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2294923961162567},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17640471458435059},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15086901187896729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1435089409351349},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008199","descriptor_name":"Lymphadenitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1888128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:2934988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:166076404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2934988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888128","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888128","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W182171637","https://openalex.org/W262449483","https://openalex.org/W277680144","https://openalex.org/W1483035379","https://openalex.org/W1506410773","https://openalex.org/W1564432735","https://openalex.org/W1594108044","https://openalex.org/W1830774137","https://openalex.org/W1980119493","https://openalex.org/W1994244606","https://openalex.org/W2005658305","https://openalex.org/W2017566938","https://openalex.org/W2022980198","https://openalex.org/W2025714343","https://openalex.org/W2027243691","https://openalex.org/W2029433408","https://openalex.org/W2030869490","https://openalex.org/W2037166864","https://openalex.org/W2039641553","https://openalex.org/W2054305049","https://openalex.org/W2071230078","https://openalex.org/W2074118418","https://openalex.org/W2087646321","https://openalex.org/W2087847435","https://openalex.org/W2126288174","https://openalex.org/W2132295926","https://openalex.org/W2138706726","https://openalex.org/W2167936032","https://openalex.org/W2176265955","https://openalex.org/W2320175395","https://openalex.org/W2326230194","https://openalex.org/W2418875295"],"related_works":["https://openalex.org/W2171770313","https://openalex.org/W2176265955","https://openalex.org/W2075662172","https://openalex.org/W4206053772","https://openalex.org/W1853595442","https://openalex.org/W4236841451","https://openalex.org/W7134064002","https://openalex.org/W4416403206","https://openalex.org/W2409947596","https://openalex.org/W2106731348"],"abstract_inverted_index":{"The":[0,45,52,105,131],"relationship":[1],"between":[2,181],"T":[3,27,74,114,120,166],"nodules":[4,28],"and":[5,19,29,60,80,86,100,125,168,185,208],"adjacent":[6,30],"B-lymphoid":[7,31,65],"follicles":[8,32],"was":[9],"investigated":[10],"in":[11,35,151,154,173,203],"37":[12],"reactive":[13],"lymph":[14],"nodes":[15],"by":[16,89,136],"light":[17],"microscopy":[18],"combined":[20],"enzyme":[21],"immunohistochemistry.":[22],"In":[23],"16":[24],"cases":[25],"(43%),":[26],"were":[33],"unified":[34],"an":[36],"ovoid,":[37],"distinct":[38],"nodular":[39],"structure":[40],"termed":[41],"a":[42,90,137,200],"\"composite":[43],"nodule.\"":[44],"composite":[46,132,183,197],"nodule":[47,133,184,198],"comprises":[48],"two":[49],"separate":[50],"domains.":[51],"peripheral,":[53],"subcapsular":[54],"B":[55,158,213],"domain":[56,159],"contains":[57,109],"all":[58,110],"stationary":[59],"migratory":[61],"elements":[62,111],"of":[63,112,139,164,189,211],"the":[64,113,157,162,165,169,178,182,186,190,196,204],"follicle,":[66],"ie,":[67,116],"B1+":[68],"B-cells,":[69],"OKT4+,":[70,117],"Leu":[71],"3a+":[72],"helper/inducer":[73,119],"cells,":[75,79,121],"HLA-DR+":[76,92],"dendritic":[77],"reticulum":[78,129],"ANAE+,":[81],"AcPhase+":[82],"tangible":[83],"body":[84],"macrophages":[85],"is":[87,134,193],"surrounded":[88,135],"B1+,":[91],"lymphocytic":[93],"corona":[94],"displaying":[95],"focal":[96],"adenosine":[97],"triphosphatase":[98],"(ATPase)":[99],"alkaline":[101],"phosphatase":[102],"(AlkPhase)":[103],"activity.":[104],"deep,":[106],"paracortical":[107],"T-domain":[108],"nodule,":[115],"Leu3a+":[118],"high":[122,142],"endothelial":[123,143],"venules":[124],"HLA-DR+,":[126],"ATPase+":[127],"interdigitating":[128],"cells.":[130,218],"rim":[138],"ATPase+,":[140],"AlkPhase+":[141],"venules.":[144],"Both":[145],"domains":[146],"are":[147],"subject":[148],"to":[149],"changes":[150],"volume;":[152],"thus,":[153],"follicular":[155],"hyperplasia,":[156],"enlarges":[160],"at":[161],"cost":[163],"domain,":[167],"reverse":[170],"may":[171],"occur":[172],"T-zone":[174],"hyperplasia.":[175],"Based":[176],"on":[177],"striking":[179],"resemblance":[180],"white":[187],"pulp":[188],"spleen,":[191],"it":[192],"suggested":[194],"that":[195],"plays":[199],"major":[201],"role":[202],"triggering,":[205],"helper-T-cell-dependent":[206],"stimulation":[207],"subsequent":[209],"maturation":[210],"antigen-responsive":[212],"cells":[214],"into":[215],"antibody-secreting":[216],"plasma":[217]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
