{"id":"https://openalex.org/W1660048993","doi":null,"title":"Interstitial methotrexate kinetics in primary breast cancer lesions.","display_name":"Interstitial methotrexate kinetics in primary breast cancer lesions.","publication_year":1998,"publication_date":"1998-07-15","ids":{"openalex":"https://openalex.org/W1660048993","mag":"1660048993","pmid":"https://pubmed.ncbi.nlm.nih.gov/9679959"},"language":"en","primary_location":{"id":"pmid:9679959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M M\u00fcller","raw_affiliation_strings":["Department of Clinical Pharmacology, Vienna University School of Medicine, Austria. markus.mueller@univie.ac.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Vienna University School of Medicine, Austria. markus.mueller@univie.ac.at","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036858038","display_name":"Martin Brunner","orcid":"https://orcid.org/0000-0002-6922-7559","observed_orcids":["https://orcid.org/0000-0002-6922-7559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brunner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159766","display_name":"R. Schmid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Schmid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087875400","display_name":"Robert M. Mader","orcid":"https://orcid.org/0000-0003-3017-8240","observed_orcids":["https://orcid.org/0000-0003-3017-8240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Mader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003771709","display_name":"J. Bockenheimer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Bockenheimer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036695602","display_name":"Guenther G. Steger","orcid":"https://orcid.org/0000-0002-0091-2611","observed_orcids":["https://orcid.org/0000-0002-0091-2611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G G Steger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081433281","display_name":"Birgit Steiner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Steiner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109920004","display_name":"Hans Georg Eichler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H G Eichler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068502941","display_name":"Brigitte Bl\u00f6chl-Daum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Bl\u00f6chl-Daum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8505,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.85438048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"58","issue":"14","first_page":"2982","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.23340000212192535,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-pharmacokinetics","display_name":"tumor pharmacokinetics","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6940000057220459},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8050000071525574},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.8144111633300781},{"id":"https://openalex.org/C150489694","wikidata":"https://www.wikidata.org/wiki/Q6057172","display_name":"Interstitial space","level":2,"score":0.8142950534820557},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.7360605597496033},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6573203802108765},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6325415372848511},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5972133874893188},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5773136019706726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5743509531021118},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4710058271884918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4029238224029541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3867560029029846},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32994329929351807},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9679959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1660048993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9679959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1538914313","https://openalex.org/W1843966557","https://openalex.org/W1964493635","https://openalex.org/W2013239827","https://openalex.org/W2022414804","https://openalex.org/W2038894713","https://openalex.org/W2055312992","https://openalex.org/W2122816286","https://openalex.org/W2187766168"],"related_works":["https://openalex.org/W2122816286","https://openalex.org/W2013239827","https://openalex.org/W2076426678","https://openalex.org/W138966902","https://openalex.org/W2023808804","https://openalex.org/W2417738626","https://openalex.org/W2412522545","https://openalex.org/W2416872503","https://openalex.org/W2071280651","https://openalex.org/W2011809647"],"abstract_inverted_index":{"The":[0],"transfer":[1,33,64,170],"of":[2,22,40,66,87,101,131,135,154,162,172,188,193,211],"cytotoxic":[3],"agents":[4],"across":[5],"the":[6,10,35,38,78,82,148,151,163,175,207,214],"tumor":[7,12,60,80,155,167],"endothelium":[8],"into":[9,37,77],"interstitial":[11,59,96,111,152,166,176,215],"space":[13,153,177,216],"is":[14,197,217],"considered":[15],"a":[16,106,198,219],"critical":[17],"step":[18,221],"in":[19,46,54,69,114,150,202],"clinical":[20,182,223],"resistance":[21],"solid":[23,41],"tumors":[24,42],"to":[25,94,174,213,225],"antineoplastic":[26],"chemotherapy.":[27,226],"However,":[28],"experimental":[29],"data":[30],"on":[31],"drug":[32],"from":[34],"blood":[36],"interstitium":[39],"are":[43,190],"scarce.":[44],"Therefore,":[45],"this":[47],"study,":[48],"we":[49],"used":[50],"an":[51],"innovative":[52],"technique,":[53],"vivo":[55],"microdialysis,":[56],"for":[57,222],"measuring":[58],"pharmacokinetics":[61],"and":[62,81,147,169],"plasma-to-tumor":[63],"rates":[65],"methotrexate":[67],"(MTX)":[68],"breast":[70,91,115],"cancer":[71,92],"patients.":[72],"Microdialysis":[73],"probes":[74],"were":[75],"inserted":[76],"primary":[79],"periumbilical":[83],"s.c.":[84],"adipose":[85],"layer":[86],"nine":[88],"previously":[89],"chemotherapy-naive":[90],"patients":[93],"monitor":[95],"concentrations":[97],"following":[98],"i.v.":[99],"administration":[100],"MTX":[102,112,138,173,189,204,212],"(40":[103],"mg/m2)":[104],"during":[105],"three-drug":[107],"treatment":[108],"regimen.":[109],"Mean":[110],"load":[113],"tumors,":[116],"expressed":[117],"as":[118],"area":[119],"under":[120],"curve":[121],"(AUC),":[122],"was":[123,141,178],"60":[124],"+/-":[125,128],"20%":[126],"(mean":[127],"SE;":[129],"coefficient":[130],"variation":[132],"=":[133,158],"100%)":[134],"mean":[136],"plasma":[137,145,186],"load.":[139],"There":[140,196],"no":[142],"correlation":[143],"between":[144],"AUC":[146,149],"tissue":[156],"(P":[157],"0.93).":[159],"Not":[160],"one":[161],"parameters":[164],"plasma,":[165],"load,":[168],"rate":[171],"associated":[179],"with":[180],"favorable":[181],"response.":[183],"In":[184],"conclusion,":[185],"levels":[187],"not":[191,218],"predictive":[192],"intratumor":[194],"levels.":[195],"high":[199],"interindividual":[200],"variability":[201],"transendothelial":[203],"transfer.":[205],"Under":[206],"present":[208],"conditions,":[209],"access":[210],"rate-limiting":[220],"response":[224]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}