{"id":"https://openalex.org/W1659065067","doi":"https://doi.org/10.1186/1471-2156-8-5","title":"Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4)","display_name":"Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4)","publication_year":2007,"publication_date":"2007-02-23","ids":{"openalex":"https://openalex.org/W1659065067","doi":"https://doi.org/10.1186/1471-2156-8-5","mag":"1659065067","pmid":"https://pubmed.ncbi.nlm.nih.gov/17319939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1810560"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2156-8-5","doi":"https://doi.org/10.1186/1471-2156-8-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-8-5","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-8-5","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-8-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022898522","display_name":"Cord Dr\u00f6gem\u00fcller","orcid":"https://orcid.org/0000-0001-9773-522X","observed_orcids":["https://orcid.org/0000-0001-9773-522X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Cord Dr\u00f6gem\u00fcller","raw_affiliation_strings":["Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3001 Berne, Switzerland. cord.droegemueller@itz.unibe.ch","Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany","Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3001 Berne, Switzerland. cord.droegemueller@itz.unibe.ch","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029969915","display_name":"Tosso Leeb","orcid":"https://orcid.org/0000-0003-0553-4880","observed_orcids":["https://orcid.org/0000-0003-0553-4880"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tosso Leeb","raw_affiliation_strings":["Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3001, Berne, Switzerland","Institute of Genetics, Vetsuisse-Faculty, University of Berne, Berne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3001, Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Institute of Genetics, Vetsuisse-Faculty, University of Berne, Berne, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068983782","display_name":"B. Harlizius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Harlizius","raw_affiliation_strings":["Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064843221","display_name":"Imke Tammen","orcid":"https://orcid.org/0000-0002-5520-6597","observed_orcids":["https://orcid.org/0000-0002-5520-6597"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["AU","DE"],"is_corresponding":false,"raw_author_name":"Imke Tammen","raw_affiliation_strings":["Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), Faculty of Veterinary Science, The University of Sydney, Camden, NSW, 2570, Australia","Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), Faculty of Veterinary Science, The University of Sydney, Camden, Australia","Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), Faculty of Veterinary Science, The University of Sydney, Camden, NSW, 2570, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Centre for Advanced Technologies in Animal Genetics and Reproduction (ReproGen), Faculty of Veterinary Science, The University of Sydney, Camden, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027198438","display_name":"O. Distl","orcid":"https://orcid.org/0000-0002-3516-836X","observed_orcids":["https://orcid.org/0000-0002-3516-836X"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ottmar Distl","raw_affiliation_strings":["Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061328114","display_name":"M. H\u00f6ltershinken","orcid":"https://orcid.org/0000-0002-8595-713X","observed_orcids":["https://orcid.org/0000-0002-8595-713X"]},"institutions":[{"id":"https://openalex.org/I189991","display_name":"University of Veterinary Medicine Hannover, Foundation","ror":"https://ror.org/015qjqf64","country_code":"DE","type":"education","lineage":["https://openalex.org/I189991"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin H\u00f6ltershinken","raw_affiliation_strings":["Clinic for Cattle, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Cattle, University of Veterinary Medicine Hannover, B\u00fcnteweg 17p, 30559, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]},{"raw_affiliation_string":"Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany","institution_ids":["https://openalex.org/I189991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028488175","display_name":"Arcangelo Gentile","orcid":"https://orcid.org/0000-0002-6091-8978","observed_orcids":["https://orcid.org/0000-0002-6091-8978"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arcangelo Gentile","raw_affiliation_strings":["Veterinary Clinical Departement, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (Bologna), Italy","Veterinary Clinical Departement, University of Bologna, Ozzano dell'Emilia (Bologna), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Clinical Departement, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (Bologna), Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Veterinary Clinical Departement, University of Bologna, Ozzano dell'Emilia (Bologna), Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085315327","display_name":"Amandine Duchesne","orcid":"https://orcid.org/0000-0002-9713-2274","observed_orcids":["https://orcid.org/0000-0002-9713-2274"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amandine Duchesne","raw_affiliation_strings":["UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, 78350, Jouy-en-Josas, France","UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, 78350, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210088668"]},{"raw_affiliation_string":"UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210088668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110933193","display_name":"Andre A. Eggen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Eggen","raw_affiliation_strings":["UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, 78350, Jouy-en-Josas, France","UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, 78350, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210088668"]},{"raw_affiliation_string":"UR339 Laboratoire de G\u00e9n\u00e9tique Biochimique et de Cytog\u00e9n\u00e9tique, INRA, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210088668"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022898522"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I189991"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":9.7191,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.98426966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.1395999938249588,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-syndactyly","display_name":"congenital syndactyly","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.6370000243186951},{"id":"https://openalex.org/keywords/holstein-cattle","display_name":"Holstein cows","score":0.7329999804496765},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.7839999794960022},{"id":"https://openalex.org/keywords/allelic-heterogeneity","display_name":"allelic heterogeneity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/autosomal-recessive-inheritance","display_name":"autosomal recessive inheritance","score":0.9909999966621399},{"id":"https://openalex.org/keywords/conserved-domains","display_name":"conserved domains","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2777202849","wikidata":"https://www.wikidata.org/wiki/Q1360044","display_name":"Syndactyly","level":2,"score":0.928695559501648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7400729060173035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7337743043899536},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.6705252528190613},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4712272882461548},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4486348032951355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41987305879592896},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.41049686074256897},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3918876647949219},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.20870041847229004}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001947","descriptor_name":"Breeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013576","descriptor_name":"Syndactyly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013576","descriptor_name":"Syndactyly","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1186/1471-2156-8-5","doi":"https://doi.org/10.1186/1471-2156-8-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-8-5","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-8-5","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1810560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1810560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genet","raw_type":"Text"},{"id":"pmid:17319939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17319939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genetics","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:hal-02665336v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02665336","pdf_url":"https://hal.inrae.fr/hal-02665336v1/file/2007_Dr%C3%B6gem%C3%BCller_BMC-Genetics_1.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genetics, 2007, 8, pp.5. ⟨10.1186/1471-2156-8-5⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.9186","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.9186","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/fa/e8/BMC_Genet_2007_Feb_23_8_5.tar.gz","raw_type":"text"},{"id":"pmh:doi:10.7892/boris.22142","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/95842","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:boris.unibe.ch:22142","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/22142/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dr\u00f6gem\u00fcller, Cord; Leeb, Tosso; Harlizius, Barbara; Tammen, Imke; Distl, Ottmar; H\u00f6ltershinken, Martin; Gentile, Arcangelo; Duchesne, Amandine; Eggen, Andr\u00e9 (2007). Congenital syndactyly in cattle: four novel mutations in the low density lipoprotein receptor-related protein 4 gene (LRP4). BMC genetics, 8, p. 5. London: BioMed Central 10.1186/1471-2156-8-5 <http://dx.doi.org/10.1186/1471-2156-8-5>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/41700","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11585/41700","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1510baf838d94df6a87d2d302362c2eb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1510baf838d94df6a87d2d302362c2eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genetics, Vol 8, Iss 1, p 5 (2007)","raw_type":"article"},{"id":"doi:10.7892/boris.22142","doi":"https://doi.org/10.7892/boris.22142","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.22142","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1186/1471-2156-8-5","doi":"https://doi.org/10.1186/1471-2156-8-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-8-5","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-8-5","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1659065067.pdf","grobid_xml":"https://content.openalex.org/works/W1659065067.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2763321","https://openalex.org/W122603613","https://openalex.org/W1483242733","https://openalex.org/W1504237050","https://openalex.org/W1932624004","https://openalex.org/W1970034422","https://openalex.org/W1988121396","https://openalex.org/W2009967392","https://openalex.org/W2017066949","https://openalex.org/W2018378713","https://openalex.org/W2053772386","https://openalex.org/W2059840190","https://openalex.org/W2072096437","https://openalex.org/W2102175769","https://openalex.org/W2106150990","https://openalex.org/W2109372707","https://openalex.org/W2109965638","https://openalex.org/W2113505118","https://openalex.org/W2136280642","https://openalex.org/W2144952519","https://openalex.org/W2164004777","https://openalex.org/W2435364203","https://openalex.org/W3209992856","https://openalex.org/W4236600141"],"related_works":["https://openalex.org/W7097207714","https://openalex.org/W1970034422","https://openalex.org/W3138445962","https://openalex.org/W2113505118","https://openalex.org/W2789522253","https://openalex.org/W2059840190","https://openalex.org/W3015584198","https://openalex.org/W6902607172","https://openalex.org/W4385751284","https://openalex.org/W3215075658"],"abstract_inverted_index":{"BACKGROUND:":[0],"Isolated":[1],"syndactyly":[2,40,106],"in":[3,19,27,41,60,85,101,107,114],"cattle,":[4],"also":[5],"known":[6],"as":[7,11,35],"mulefoot,":[8],"is":[9],"inherited":[10],"an":[12],"autosomal":[13],"recessive":[14],"trait":[15],"with":[16],"variable":[17],"penetrance":[18],"different":[20,122],"cattle":[21,46],"breeds.":[22,47],"Recently,":[23],"two":[24,57],"independent":[25,119],"mutations":[26,83,100,113,120,132],"the":[28,36,42,51,63,75,102,115,127],"bovine":[29],"LRP4":[30,54,80,99,116,131],"gene":[31,117],"have":[32],"been":[33],"reported":[34],"primary":[37],"cause":[38],"of":[39,62,77,98,104,140],"Holstein":[43,65],"and":[44,67,89],"Angus":[45],"RESULTS:":[48],"We":[49,93],"confirmed":[50,94],"previously":[52],"described":[53,130],"exon":[55],"33":[56],"nucleotide":[58],"substitution":[59],"most":[61],"affected":[64],"calves":[66],"revealed":[68],"additional":[69],"evidence":[70],"for":[71],"allelic":[72],"heterogeneity":[73],"by":[74],"identification":[76],"four":[78,128],"new":[79],"non-synonymous":[81],"point":[82],"co-segregating":[84],"Holstein,":[86],"German":[87],"Simmental":[88],"Simmental-Charolais":[90],"families.":[91],"CONCLUSION:":[92],"a":[95],"significant":[96],"role":[97],"pathogenesis":[103],"congenital":[105],"cattle.":[108],"The":[109],"newly":[110,129],"detected":[111],"missense":[112],"represent":[118],"affecting":[121],"conserved":[123],"protein":[124],"domains.":[125],"However,":[126],"do":[133],"still":[134],"not":[135],"explain":[136],"all":[137],"analyzed":[138],"cases":[139],"syndactyly.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}