{"id":"https://openalex.org/W165649003","doi":null,"title":"Steroidal glycosides from the underground parts of Allium ursinum L. and their cytostatic and antimicrobial activity.","display_name":"Steroidal glycosides from the underground parts of Allium ursinum L. and their cytostatic and antimicrobial activity.","publication_year":2006,"publication_date":"2006-05-01","ids":{"openalex":"https://openalex.org/W165649003","mag":"165649003","pmid":"https://pubmed.ncbi.nlm.nih.gov/20085228"},"language":"en","primary_location":{"id":"pmid:20085228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20085228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ruj.uj.edu.pl/xmlui/handle/item/176919","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077049775","display_name":"Danuta Sobolewska","orcid":"https://orcid.org/0000-0001-6242-5133","observed_orcids":["https://orcid.org/0000-0001-6242-5133"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Danuta Sobolewska","raw_affiliation_strings":["Department of Pharmacognosy, Collegium Medicum, Jagiellonian University, Krak\u00f3w, Poland. dsobolew@cm-uj.krakow.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Collegium Medicum, Jagiellonian University, Krak\u00f3w, Poland. dsobolew@cm-uj.krakow.pl","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112318248","display_name":"Zbigniew Janeczko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zbigniew Janeczko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069026850","display_name":"Wanda Kisiel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wanda Kisiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077436871","display_name":"Irma Podolak","orcid":"https://orcid.org/0000-0002-1251-7192","observed_orcids":["https://orcid.org/0000-0002-1251-7192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irma Podolak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045288946","display_name":"Agnieszka Galanty","orcid":"https://orcid.org/0000-0001-5636-8646","observed_orcids":["https://orcid.org/0000-0001-5636-8646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Galanty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020055429","display_name":"Danuta Trojanowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danuta Trojanowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.00814853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"63","issue":"3","first_page":"219","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13185","display_name":"Phytochemistry and Bioactive Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steroidal-glycosides","display_name":"steroid glycosides","score":0.8679999709129333},{"id":"https://openalex.org/keywords/allium-ursinum","display_name":"wild garlic","score":0.9810000061988831},{"id":"https://openalex.org/keywords/spirostanol-saponins","display_name":"spirostanol saponins","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.7829999923706055},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/trichophyton-mentagrophytes","display_name":"Trichophyton mentagrophytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/microsporum-canis","display_name":"Microsporum canis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fungal-skin-infection","display_name":"fungal skin infection","score":0.4690000116825104},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7187767624855042},{"id":"https://openalex.org/C2778297098","wikidata":"https://www.wikidata.org/wiki/Q419827","display_name":"Tetrasaccharide","level":3,"score":0.71196448802948},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.6791311502456665},{"id":"https://openalex.org/C2775874440","wikidata":"https://www.wikidata.org/wiki/Q310925","display_name":"Trichophyton","level":3,"score":0.6179758310317993},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5423335433006287},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4895980954170227},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47982239723205566},{"id":"https://openalex.org/C2776517583","wikidata":"https://www.wikidata.org/wiki/Q140376","display_name":"Microsporum canis","level":3,"score":0.4627833962440491},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.4256399869918823},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.4235548973083496},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.39695727825164795},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.320283979177475},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.229503333568573},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.20459771156311035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15387490391731262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08262398838996887},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.06038263440132141}],"mesh":[{"descriptor_ui":"D000490","descriptor_name":"Allium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008864","descriptor_name":"Microsporum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014249","descriptor_name":"Trichophyton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054697","descriptor_name":"Cytostatic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054697","descriptor_name":"Cytostatic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20085228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20085228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/176919","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/176919","pdf_url":"https://ruj.uj.edu.pl/xmlui/handle/item/176919","source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:165649003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20085228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ruj.uj.edu.pl:item/176919","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/176919","pdf_url":"https://ruj.uj.edu.pl/xmlui/handle/item/176919","source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W165649003.pdf","grobid_xml":"https://content.openalex.org/works/W165649003.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7052886796","https://openalex.org/W2313184878","https://openalex.org/W2002978554","https://openalex.org/W2040680738","https://openalex.org/W1965693825","https://openalex.org/W3117187910","https://openalex.org/W2312900357","https://openalex.org/W1990610954","https://openalex.org/W1995573050","https://openalex.org/W2049264502"],"abstract_inverted_index":{"The":[0,23,43,62,90],"aim":[1],"of":[2,11,18,25,45,64,69,72],"this":[3],"study":[4],"was":[5,94],"the":[6,15,26,70],"isolation":[7],"and":[8,35,37,40,51,80,83,106],"structural":[9],"elucidation":[10],"steroidal":[12,47],"glycosides":[13],"from":[14],"underground":[16],"parts":[17],"ramson":[19],"Allium":[20],"ursinum":[21],"L.":[22],"structures":[24],"isolated":[27],"compounds":[28],"were":[29,60],"established":[30],"based":[31],"upon":[32],"chromatographic":[33],"methods":[34],"1D-":[36],"2D-NMR,":[38],"MS":[39],"IR":[41],"analyses.":[42],"mixture":[44,71,93],"two":[46],"saponins:":[48],"(25R)-spirost-5-en-3b-ol":[49],"tetrasaccharide":[50],"(25R)-spirost-5,":[52],"25(27)-dien-3b-ol":[53],"tetrasaccharide,":[54],"along":[55],"with":[56],"a":[57],"3-hydroxypregna-5,16-dien-20-one":[58],"glycoside":[59],"identified.":[61],"results":[63],"in":[65,99],"vitro":[66,100],"cytotoxic":[67],"activity":[68,102],"spirostanol":[73,91],"saponins":[74,92],"against":[75,103],"cell":[76],"lines":[77],"melanoma":[78],"B16":[79],"sarcoma":[81],"XC":[82],"human":[84],"fibroblasts":[85],"HSF":[86],"are":[87],"also":[88],"reported.":[89],"investigated":[95],"to":[96],"determine":[97],"its":[98],"antimicrobal":[101],"Trichophyton":[104],"mentagrophytes":[105],"Microsporum":[107],"canis.":[108]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}