{"id":"https://openalex.org/W1655422333","doi":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","title":"An immunoreceptor tyrosine\u2010based inhibitory motif, with serine at site Y\u20102, binds SH2\u2010domain\u2010containing phosphatases","display_name":"An immunoreceptor tyrosine\u2010based inhibitory motif, with serine at site Y\u20102, binds SH2\u2010domain\u2010containing phosphatases","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W1655422333","doi":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","mag":"1655422333","pmid":"https://pubmed.ncbi.nlm.nih.gov/10651806"},"language":"en","primary_location":{"id":"doi:10.1046/j.1432-1327.2000.01044.x","doi":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2000.01044.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2000.01044.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004381340","display_name":"Rachel Philosof\u2010Oppenheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rachel Philosof\u2010Oppenheimer","raw_affiliation_strings":["Departments of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel","Departments of Organic Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Departments of Organic Chemistry and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036401896","display_name":"Christiane S. Hampe","orcid":"https://orcid.org/0000-0001-9111-6671","observed_orcids":["https://orcid.org/0000-0001-9111-6671"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Christiane S. Hampe","raw_affiliation_strings":["Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009263163","display_name":"Karni Schlessinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Karni Schlessinger","raw_affiliation_strings":["Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109032535","display_name":"Mati Fridkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mati Fridkin","raw_affiliation_strings":["Departments of Organic Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Organic Chemistry and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021244474","display_name":"Israel Pecht","orcid":"https://orcid.org/0000-0002-1883-9547","observed_orcids":["https://orcid.org/0000-0002-1883-9547"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Israel Pecht","raw_affiliation_strings":["Immunology, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021244474"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":1.4144,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79953218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"267","issue":"3","first_page":"703","last_page":"711"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.23270000517368317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itim","display_name":"ITIM","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.5870000123977661},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":1.0},{"id":"https://openalex.org/keywords/ships","display_name":"ships","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.777999997138977},{"id":"https://openalex.org/keywords/thiophosphorylation","display_name":"thiophosphorylation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/receptor-dephosphorylation","display_name":"receptor dephosphorylation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"surface plasmon resonance","score":0.7289999723434448},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.5519999861717224},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C29907709","wikidata":"https://www.wikidata.org/wiki/Q6005558","display_name":"Immunoreceptor tyrosine-based activation motif","level":5,"score":0.7043520212173462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6507377624511719},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6426228284835815},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6314979791641235},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5528002381324768},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5458834171295166},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5413304567337036},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.5313905477523804},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.5085448026657104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49944519996643066},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.46147510409355164},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4421396553516388},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.416952908039093},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4160847067832947},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4116837978363037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34380483627319336},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3407752215862274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017455","descriptor_name":"Receptors, IgE","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1432-1327.2000.01044.x","doi":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2000.01044.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:10651806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10651806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1432-1327.2000.01044.x","doi":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1432-1327.2000.01044.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1432-1327.2000.01044.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1655422333.pdf","grobid_xml":"https://content.openalex.org/works/W1655422333.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W578366578","https://openalex.org/W1494573464","https://openalex.org/W1497168175","https://openalex.org/W1502226870","https://openalex.org/W1529522766","https://openalex.org/W1548757245","https://openalex.org/W1571576266","https://openalex.org/W1969335237","https://openalex.org/W1972395912","https://openalex.org/W1976805459","https://openalex.org/W1977156769","https://openalex.org/W1977997493","https://openalex.org/W1979591369","https://openalex.org/W1980166477","https://openalex.org/W1980776953","https://openalex.org/W1982833418","https://openalex.org/W1984838238","https://openalex.org/W1985782864","https://openalex.org/W1991399144","https://openalex.org/W1993343317","https://openalex.org/W1995829836","https://openalex.org/W1996003806","https://openalex.org/W2000061036","https://openalex.org/W2006370393","https://openalex.org/W2012163630","https://openalex.org/W2012347775","https://openalex.org/W2018788333","https://openalex.org/W2018826402","https://openalex.org/W2025485285","https://openalex.org/W2026337553","https://openalex.org/W2027724167","https://openalex.org/W2030793757","https://openalex.org/W2037133606","https://openalex.org/W2038643556","https://openalex.org/W2042209841","https://openalex.org/W2042354340","https://openalex.org/W2048345403","https://openalex.org/W2048841771","https://openalex.org/W2051378684","https://openalex.org/W2053142169","https://openalex.org/W2053335282","https://openalex.org/W2056160061","https://openalex.org/W2056462157","https://openalex.org/W2058885870","https://openalex.org/W2058924545","https://openalex.org/W2060101293","https://openalex.org/W2069097227","https://openalex.org/W2069545269","https://openalex.org/W2078146013","https://openalex.org/W2083480719","https://openalex.org/W2083920899","https://openalex.org/W2091898920","https://openalex.org/W2091949611","https://openalex.org/W2093844017","https://openalex.org/W2110000889","https://openalex.org/W2111989184","https://openalex.org/W2117290213","https://openalex.org/W2125886784","https://openalex.org/W2141179251","https://openalex.org/W2144954864","https://openalex.org/W2146573379","https://openalex.org/W2146861726","https://openalex.org/W2157118802","https://openalex.org/W2158449767","https://openalex.org/W2165742826","https://openalex.org/W2301898163","https://openalex.org/W2920822596"],"related_works":["https://openalex.org/W1652839515","https://openalex.org/W2069097227","https://openalex.org/W1999472502","https://openalex.org/W1985782864","https://openalex.org/W1598285904","https://openalex.org/W2117290213","https://openalex.org/W2078820123","https://openalex.org/W2089736055","https://openalex.org/W2080776128","https://openalex.org/W1970746962"],"abstract_inverted_index":{"Clustering":[0],"of":[1,21,43,62,82,129,135,218,231,247,285,297,302],"the":[2,14,22,39,63,72,97,117,148,159,207,232,254,258,271,298],"mast":[3,23,64,83,91,136,237,276],"cell":[4,24,65,84,92,137,238,259,277],"function-associated":[5,25,66,93,138,239,278],"antigen":[6,26,94,139,240],"by":[7,203,226],"its":[8,121],"specific":[9],"monoclonal":[10],"antibody":[11],"(G63)":[12],"inhibits":[13],"FcepsilonRI-mediated":[15],"secretory":[16],"response.":[17],"The":[18],"cytosolic":[19,280],"tail":[20,281],"contains":[27],"a":[28,31,294],"SIYSTL":[29,272],"stretch,":[30],"potential":[32,50],"immunoreceptor":[33,287,303],"tyrosine-based":[34,288,304],"inhibition":[35,289,305],"motif.":[36],"To":[37],"investigate":[38],"possible":[40],"functional":[41],"role":[42],"this":[44,178,182],"sequence,":[45],"as":[46,48,173],"well":[47],"identify":[49],"intracellular":[51],"proteins":[52],"that":[53,144,206,253,270],"interact":[54],"with":[55,113,169],"it,":[56],"peptides":[57,95],"corresponding":[58],"to":[59,158,215],"residues":[60,189],"4-12":[61],"antigen's":[67,279],"N-terminal":[68],"cytoplasmic":[69],"domain,":[70],"containing":[71],"above":[73],"motif,":[74,290],"were":[75,224],"synthesized":[76],"and":[77,89,108,165,175,187,220,242,250],"used":[78],"in":[79,257,275],"affinity":[80],"chromatography":[81],"lysates.":[85],"Both":[86],"tyrosyl":[87,122,235],"phosphorylated":[88,123,236],"thiophosphorylated":[90],"bound":[96,127],"src":[98],"homology":[99],"domain":[100],"2":[101],"(SH2)-containing":[102],"tyrosine":[103],"phosphatases-1":[104],"(SHP-1),":[105],"-2":[106],"(SHP-2)":[107],"inositol":[109],"5'-phosphatase":[110],"(SHIP),":[111],"though":[112],"different":[114],"efficiencies.":[115],"Neither":[116],"nonphosphorylated":[118],"peptide":[119,126,213,241],"nor":[120],"reversed":[124],"sequence":[125],"any":[128],"these":[130,266],"phosphatases.":[131],"Point":[132],"mutation":[133],"analysis":[134],"pITIM":[140],"binding":[141,183,195,214],"requirements":[142],"demonstrated":[143],"for":[145,212],"SHP-2":[146,249],"association":[147],"amino":[149,167],"acid":[150],"residue":[151],"at":[152,177],"position":[153,179,209],"Y-2":[154,208],"is":[155,293],"not":[156],"restricted":[157],"hydrophobic":[160],"isoleucine":[161],"or":[162],"valine.":[163],"Glycine":[164],"other":[166],"acids":[168],"hydrophilic":[170],"residues,":[171],"such":[172],"serine":[174,200],"threonine,":[176],"also":[180],"maintain":[181],"capacity,":[184],"whereas":[185],"alanine":[186],"acidic":[188],"abolish":[190],"it.":[191],"In":[192],"contrast,":[193],"SHP-1":[194,219],"was":[196,201],"maintained":[197],"only":[198],"when":[199],"substituted":[202],"valine,":[204],"suggesting":[205,252,291],"provides":[210],"selectivity":[211],"SH2":[216,245],"domains":[217,246],"SHP-2.":[221],"These":[222],"results":[223,267],"corroborated":[225],"surface":[227],"plasmon":[228],"resonance":[229],"measurements":[230],"interaction":[233],"between":[234],"recombinant":[243],"soluble":[244],"SHP-1,":[248],"SHIP,":[251],"associations":[255],"observed":[256],"lysates":[260],"may":[261],"be":[262],"direct.":[263],"Taken":[264],"together":[265],"clearly":[268],"indicate":[269],"motif":[273],"present":[274],"exhibits":[282],"characteristic":[283],"features":[284],"an":[286],"it":[292],"new":[295],"member":[296],"growing":[299],"diverse":[300],"family":[301],"motif-containing":[306],"receptors.":[307]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}