{"id":"https://openalex.org/W165501223","doi":null,"title":"Mouse Models of Neuroanatomical, Behavioral, and Genetic Correlates of Language-related Impairments: an Investigation of Core Phenotypes.","display_name":"Mouse Models of Neuroanatomical, Behavioral, and Genetic Correlates of Language-related Impairments: an Investigation of Core Phenotypes.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W165501223","mag":"165501223"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6708","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/458","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6708&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6708&context=dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110556759","display_name":"Dongnhu T. Truong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongnhu T. Truong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110556759"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.7265999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10730","display_name":"Language Development and Disorders","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10103","display_name":"Reading and Literacy Development","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/language-impairment","display_name":"language impairment","score":0.7799999713897705},{"id":"https://openalex.org/keywords/dyslexia","display_name":"dyslexia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/specific-language-impairment","display_name":"specific language impairment","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6930000185966492},{"id":"https://openalex.org/keywords/recombinant-inbred-mice","display_name":"recombinant inbred mouse strains","score":0.824999988079071},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.996999979019165},{"id":"https://openalex.org/keywords/dcdc2","display_name":"DCDC2","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cntnap2","display_name":"CNTNAP2","score":1.0},{"id":"https://openalex.org/keywords/neuronal-migration","display_name":"neuronal migration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.7900000214576721},{"id":"https://openalex.org/keywords/auditory-processing","display_name":"auditory processing","score":0.6539999842643738},{"id":"https://openalex.org/keywords/social-communication","display_name":"social communication","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuroanatomy","display_name":"neuroanatomy","score":0.5389999747276306},{"id":"https://openalex.org/keywords/risk-genes","display_name":"risk genes","score":0.550000011920929},{"id":"https://openalex.org/keywords/reading-disabilities","display_name":"reading disorders","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.575218915939331},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5089128017425537},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5008845329284668},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.41839170455932617},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.33917367458343506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24950256943702698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17359745502471924},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6708","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/458","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6708&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-6708","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/458","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:165501223","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/458/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6708","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/458","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6708&context=dissertations","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4230337841","display_name":"IGERT:  Language plasticity - Genes, Brain, Cognition and Computation","funder_award_id":"1144399","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W165501223.pdf","grobid_xml":"https://content.openalex.org/works/W165501223.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2765161726","https://openalex.org/W4239779581","https://openalex.org/W2094103671","https://openalex.org/W1941469249","https://openalex.org/W4388157548","https://openalex.org/W1497315158","https://openalex.org/W2131141565","https://openalex.org/W2971945804","https://openalex.org/W7099009406","https://openalex.org/W1513557478"],"abstract_inverted_index":{"The":[0],"development":[1,69,219],"of":[2,22,66,75,128,186,220,225,242,257,279,329,337],"the":[3,93,126,129,164,184,210,218,223,288,335],"brain":[4],"is":[5,11,57,136],"an":[6,145],"immensely":[7],"complicated":[8],"process":[9],"that":[10,61,104,153,196],"highly":[12],"regulated":[13],"by":[14],"numerous":[15,101],"genetic":[16,96,102,240],"pathways.":[17],"Disruption":[18],"within":[19],"any":[20],"stage":[21],"this":[23,229],"operation\u2014from":[24],"proliferation,":[25],"to":[26,29,33,47,125,148,157,179,200,213,233,305],"neuronal":[27,280,330],"migration,":[28,331],"synaptogenesis\u2014could":[30],"ultimately":[31],"lead":[32],"deleterious":[34],"behavioral":[35,181,268],"outcomes,":[36],"ranging":[37],"from":[38,65,312],"severe":[39],"intellectual":[40],"disability":[41,178],"and":[42,87,111,189,205,235,239,244,254,274,292,318,321,339],"gross":[43],"motor":[44],"developmental":[45],"delays":[46],"more":[48,106],"subtle":[49],"cognitive":[50,190,340],"impairments":[51],"such":[52,80],"as":[53,81,323,325],"language":[54,76,83,110,177,204,221,243,272],"disability.":[55],"It":[56],"therefore":[58],"no":[59],"surprise":[60],"neuroanatomical":[62,327],"anomalies":[63,328],"resulting":[64],"altered":[67],"cortical":[68],"are":[70,105,123,154],"associated":[71,175,270,326],"with":[72,176,271],"a":[73],"number":[74],"related":[77,246],"neurodevelopmental":[78],"disorders":[79,90,247],"specific":[82],"impairment":[84],"(SLI),":[85],"dyslexia,":[86],"autism":[88],"spectrum":[89],"(ASD).":[91],"Over":[92],"past":[94,165],"decade,":[95],"association":[97,132],"studies":[98,117,226],"have":[99,143,166,197],"identified":[100,311],"variants":[103],"commonly":[107],"observed":[108,342],"in":[109,163,169,183,203,228,248,284,343],"reading":[112,206,245],"impaired":[113,207],"populations.":[114,208,346],"However,":[115],"these":[116,121,260,297,300],"cannot":[118],"ascertain":[119],"whether":[120],"genes":[122,310],"central":[124,289],"etiology":[127],"disorder":[130],"(since":[131],"but":[133],"not":[134],"causatlity":[135],"repoterd).":[137],"As":[138],"another":[139],"approach,":[140],"rodent":[141,161],"models":[142,162],"provided":[144],"invaluable":[146],"tool":[147],"elucidate":[149],"functional":[150],"gene-brain-behavior":[151],"relationships":[152,264],"nearly":[155],"impossible":[156],"examine":[158,234],"clinically.":[159],"Indeed,":[160],"been":[167,198],"successful":[168],"linking":[170],"clinically":[171],"relevant":[172,344],"neuropathological":[173],"changes":[174,283],"poor":[180],"outcomes":[182],"domains":[185],"auditory":[187,290],"processing":[188],"performance":[191],"on":[192],"water":[193],"maze":[194],"tasks\u2014behaviors":[195],"shown":[199],"be":[201],"deficient":[202],"Given":[209],"pressing":[211],"need":[212],"understand":[214],"how":[215,307],"genetics":[216],"underlie":[217],"dysfunction,":[222],"series":[224],"presented":[227],"thesis":[230],"was":[231,304],"designed":[232],"characterize":[236],"neurobehavioral,":[237],"neuroanatomic,":[238],"profiles":[241],"rodents,":[249],"specifically":[250],"using":[251],"recombinant":[252],"inbred":[253],"transgenic":[255],"strains":[256],"mice.":[258],"In":[259],"experiments,":[261],"we":[262],"defined":[263],"between:":[265],"1)":[266],"key":[267],"phenotypes":[269],"dysfunction":[273],"social":[275],"communication/interaction;":[276],"2)":[277],"disruption":[278],"migration;":[281],"3)":[282],"subcortical":[285],"anatomy":[286],"along":[287],"pathway;":[291],"4)":[293],"sex":[294],"differences":[295],"across":[296],"factors.":[298],"From":[299],"relationships,":[301],"our":[302],"goal":[303],"identify":[306],"promising":[308],"risk":[309],"clinical":[313,345],"populations":[314],"(e.g.,":[315],"DCDC2":[316],"(dyslexia)":[317],"CNTNAP2":[319],"(SLI":[320],"ASD))":[322],"well":[324],"may":[332],"collectively":[333],"mediate":[334],"constellation":[336],"language-related":[338],"dysfunctions":[341]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
