{"id":"https://openalex.org/W1654903675","doi":"https://doi.org/10.3233/jad-130428","title":"Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients","display_name":"Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients","publication_year":2013,"publication_date":"2013-10-29","ids":{"openalex":"https://openalex.org/W1654903675","doi":"https://doi.org/10.3233/jad-130428","mag":"1654903675","pmid":"https://pubmed.ncbi.nlm.nih.gov/23948933"},"language":"en","primary_location":{"id":"doi:10.3233/jad-130428","doi":"https://doi.org/10.3233/jad-130428","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-130428","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111554391","display_name":"Patr\u00edcia Nat\u00e1lia Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia Natalia Silva","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033533789","display_name":"Tatiane Katsue Furuya","orcid":"https://orcid.org/0000-0003-4643-8254","observed_orcids":["https://orcid.org/0000-0003-4643-8254"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tatiane Katsue Furuya","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020298707","display_name":"Ianna Lacerda Sampaio Braga","orcid":"https://orcid.org/0000-0002-0298-3456","observed_orcids":["https://orcid.org/0000-0002-0298-3456"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ianna Lacerda Braga","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060212289","display_name":"Lucas Trevizani Rasmussen","orcid":"https://orcid.org/0000-0002-9033-2257","observed_orcids":["https://orcid.org/0000-0002-9033-2257"]},"institutions":[{"id":"https://openalex.org/I151854742","display_name":"Faculdade de Medicina de Mar\u00edlia","ror":"https://ror.org/00pm9hx30","country_code":"BR","type":"education","lineage":["https://openalex.org/I151854742"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas Trevizani Rasmussen","raw_affiliation_strings":["Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil","institution_ids":["https://openalex.org/I151854742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698803","display_name":"Roger Willian de L\u00e1bio","orcid":"https://orcid.org/0000-0002-6901-6663","observed_orcids":["https://orcid.org/0000-0002-6901-6663"]},"institutions":[{"id":"https://openalex.org/I151854742","display_name":"Faculdade de Medicina de Mar\u00edlia","ror":"https://ror.org/00pm9hx30","country_code":"BR","type":"education","lineage":["https://openalex.org/I151854742"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roger Willian Labio","raw_affiliation_strings":["Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil","institution_ids":["https://openalex.org/I151854742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064814871","display_name":"Paulo Henrique Ferreira Bertolucci","orcid":"https://orcid.org/0000-0001-7902-7502","observed_orcids":["https://orcid.org/0000-0001-7902-7502"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Henrique Bertolucci","raw_affiliation_strings":["Disciplina de Neurologia Cl\u00ednica, Departamento de Neurologia e Neurocirurgia (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Neurologia Cl\u00ednica, Departamento de Neurologia e Neurocirurgia (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108049721","display_name":"Elizabeth Chen","orcid":"https://orcid.org/0000-0002-3573-0164","observed_orcids":["https://orcid.org/0000-0002-3573-0164"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizabeth Suchi Chen","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002118289","display_name":"Gustavo Turecki","orcid":"https://orcid.org/0000-0003-4075-2736","observed_orcids":["https://orcid.org/0000-0003-4075-2736"]},"institutions":[{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gustavo Turecki","raw_affiliation_strings":["Psychiatry Department, Douglas Hospital Research Center, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Douglas Hospital Research Center, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036446265","display_name":"Naguib Mechawar","orcid":"https://orcid.org/0000-0003-4960-756X","observed_orcids":["https://orcid.org/0000-0003-4960-756X"]},"institutions":[{"id":"https://openalex.org/I2799434747","display_name":"Douglas Mental Health University Institute","ror":"https://ror.org/05dk2r620","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799434747"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Naguib Mechawar","raw_affiliation_strings":["Psychiatry Department, Douglas Hospital Research Center, McGill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Douglas Hospital Research Center, McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I2799434747","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006660349","display_name":"Spencer Lu\u00edz Marques Pay\u00e3o","orcid":"https://orcid.org/0000-0003-4373-7742","observed_orcids":["https://orcid.org/0000-0003-4373-7742"]},"institutions":[{"id":"https://openalex.org/I151854742","display_name":"Faculdade de Medicina de Mar\u00edlia","ror":"https://ror.org/00pm9hx30","country_code":"BR","type":"education","lineage":["https://openalex.org/I151854742"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Spencer Luiz Pay\u00e3o","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Laborat\u00f3rio de Gen\u00e9tica, Hemocentro, Faculdade de Medicina de Mar\u00edlia (FAMEMA), Mar\u00edlia, SP, Brazil","institution_ids":["https://openalex.org/I151854742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049350976","display_name":"Jonathan S. Mill","orcid":"https://orcid.org/0000-0003-1115-3224","observed_orcids":["https://orcid.org/0000-0003-1115-3224","https://orcid.org/0000-0002-3424-5511"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Mill","raw_affiliation_strings":["Institute of Psychiatry, King's College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, King's College, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008630972","display_name":"Mar\u00edlia de Arruda Cardoso Smith","orcid":"https://orcid.org/0000-0002-1441-1033","observed_orcids":["https://orcid.org/0000-0002-1441-1033"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mar\u00edlia Cardoso Smith","raw_affiliation_strings":["Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de Gen\u00e9tica, Departamento de Morfologia e Gen\u00e9tica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.693,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.80569021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"38","issue":"1","first_page":"165","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hsc70","display_name":"Hsc70","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7396277785301208},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5825017094612122},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5806518793106079},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45633596181869507},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45268502831459045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44471901655197144},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4400065243244171},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.42948126792907715},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42445647716522217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3881821632385254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36849692463874817},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32184475660324097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2500231862068176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23241442441940308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16442853212356567}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-130428","doi":"https://doi.org/10.3233/jad-130428","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-130428","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:23948933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23948933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/4dd610ab-b6d4-4f1f-b955-5c3d084bba19","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/4dd610ab-b6d4-4f1f-b955-5c3d084bba19","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Silva, P N, Furuya, T K, Braga, I L, Rasmussen, L T, Labio, R W, Bertolucci, P H, Chen, E S, Turecki, G, Mechawar, N, Payao, S L, Mill, J & Smith, M C 2014, 'Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients', JOURNAL OF ALZHEIMERS DISEASE, vol. 38, no. 1, N/A, pp. 165-170. https://doi.org/10.3233/JAD-130428","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/37299","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/37299","pdf_url":null,"source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artigo"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1966923623","https://openalex.org/W1979477211","https://openalex.org/W2001355289","https://openalex.org/W2013391120","https://openalex.org/W2019845348","https://openalex.org/W2031618067","https://openalex.org/W2034103309","https://openalex.org/W2051561353","https://openalex.org/W2070301080","https://openalex.org/W2071057846","https://openalex.org/W2074697072","https://openalex.org/W2084210522","https://openalex.org/W2096038757","https://openalex.org/W2098362718","https://openalex.org/W2101861123","https://openalex.org/W2106814023","https://openalex.org/W2111774300","https://openalex.org/W2111858669","https://openalex.org/W2156220037"],"related_works":["https://openalex.org/W2029568243","https://openalex.org/W7120659600","https://openalex.org/W2051561353","https://openalex.org/W1520634183","https://openalex.org/W340820028","https://openalex.org/W2321300846","https://openalex.org/W4311507691","https://openalex.org/W1985979621","https://openalex.org/W2906541279","https://openalex.org/W2784110008"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3],"the":[4,36,90,122,128],"most":[5],"common":[6],"form":[7],"of":[8,43,71,113],"dementia":[9],"in":[10,18,24,49,68,100,119,133,151],"elderly.":[11],"Chaperones":[12],"may":[13,148],"have":[14],"a":[15,97],"crucial":[16],"role":[17],"AD":[19,63,75,120,134],"due":[20],"to":[21,127],"their":[22,131],"involvement":[23],"protein":[25],"quality":[26],"control,":[27],"folding,":[28],"and":[29,38,47,54,57,62,74,83,102,108,115],"degradation.":[30],"In":[31,89],"this":[32],"study,":[33],"we":[34,93],"investigated":[35],"mRNA":[37,77],"promoter":[39],"DNA":[40,84,139],"methylation":[41,85,140],"levels":[42],"two":[44],"chaperones,":[45],"HSPA8":[46,101,114],"HSPA9,":[48],"postmortem":[50],"brain":[51,124],"tissue":[52],"(entorhinal":[53],"auditory":[55],"cortices":[56],"hippocampus)":[58],"from":[59],"healthy":[60,72],"elderly":[61,73,106],"subjects":[64],"as":[65,67],"well":[66],"peripheral":[69,91],"blood":[70],"patients.":[76],"quantification":[78],"was":[79,117],"performed":[80],"by":[81,86],"qRT-PCR":[82],"mass":[87],"spectrometry.":[88],"blood,":[92],"did":[94],"not":[95],"observe":[96],"significant":[98,111],"difference":[99],"HSPA9":[103,116],"expression":[104],"between":[105],"controls":[107],"AD.":[109],"A":[110],"downregulation":[112],"observed":[118],"across":[121],"three":[123],"regions":[125],"compared":[126],"controls,":[129],"suggesting":[130,144],"participation":[132],"pathogenesis.":[135],"However,":[136],"no":[137],"important":[138],"differences":[141],"were":[142],"observed,":[143],"that":[145],"other":[146],"mechanism":[147],"be":[149],"involved":[150],"controlling":[152],"these":[153],"genes":[154],"expression.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}