{"id":"https://openalex.org/W165466573","doi":null,"title":"Recognition of N-glycosidic carbohydrates on esophageal carcinoma cells by macrophage cell line THP-1.","display_name":"Recognition of N-glycosidic carbohydrates on esophageal carcinoma cells by macrophage cell line THP-1.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W165466573","mag":"165466573","pmid":"https://pubmed.ncbi.nlm.nih.gov/2167012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877603"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R Takano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R Takano","raw_affiliation_strings":["Department of Pathology, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003627407","display_name":"M Nose","orcid":"https://orcid.org/0000-0001-8724-3352","observed_orcids":["https://orcid.org/0000-0001-8724-3352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Kanno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kanno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083243384","display_name":"Tetsuro Nishihira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nishihira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035548268","display_name":"Sen Hiraizumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hiraizumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067110679","display_name":"Akira Kobata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kobata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109838262","display_name":"M Kyogoku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kyogoku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3588,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.49143688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"137","issue":"2","first_page":"393","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tumor-cell-macrophage-interaction","display_name":"macrophage-tumor cell interaction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.8080000281333923},{"id":"https://openalex.org/keywords/superoxide-release","display_name":"superoxide release","score":0.8090000152587891},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/host-defense-against-tumors","display_name":"host defense against tumors","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7142308950424194},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5873686075210571},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.5198084115982056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4723188579082489},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.4661703407764435},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46522921323776245},{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.4326583743095398},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.42267894744873047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36690694093704224},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.35254502296447754},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3494570851325989},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3471853733062744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34646809101104736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3279627561569214},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25387078523635864},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06792598962783813},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014415","descriptor_name":"Tunicamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:2167012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2167012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1877603","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1877603/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:165466573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2167012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1505864298","https://openalex.org/W1557135880","https://openalex.org/W1566332159","https://openalex.org/W1578874979","https://openalex.org/W1591853650","https://openalex.org/W1629179716","https://openalex.org/W1750690213","https://openalex.org/W1902587173","https://openalex.org/W1928211543","https://openalex.org/W1940436875","https://openalex.org/W1944876093","https://openalex.org/W1983702870","https://openalex.org/W1984271271","https://openalex.org/W1993806898","https://openalex.org/W1997297528","https://openalex.org/W2007835830","https://openalex.org/W2018289835","https://openalex.org/W2026829219","https://openalex.org/W2033567679","https://openalex.org/W2035870763","https://openalex.org/W2061327866","https://openalex.org/W2067295489","https://openalex.org/W2070623104","https://openalex.org/W2073426767","https://openalex.org/W2074387820","https://openalex.org/W2078958514","https://openalex.org/W2080801905","https://openalex.org/W2084085105","https://openalex.org/W2084431025","https://openalex.org/W2086143621","https://openalex.org/W2087092024","https://openalex.org/W2098621632","https://openalex.org/W2101108802","https://openalex.org/W2117596832","https://openalex.org/W2127310510","https://openalex.org/W2146086791","https://openalex.org/W2174934515","https://openalex.org/W2413342668"],"related_works":["https://openalex.org/W2485039204","https://openalex.org/W2026829219","https://openalex.org/W7120286354","https://openalex.org/W2008151558","https://openalex.org/W92440","https://openalex.org/W1557398086","https://openalex.org/W2003970749","https://openalex.org/W2070236840","https://openalex.org/W3113196734","https://openalex.org/W2110069303"],"abstract_inverted_index":{"Cell-to-cell":[0],"contact":[1],"between":[2],"macrophages":[3],"and":[4],"tumor":[5,18],"cells":[6,31,108,146],"is":[7],"an":[8,85],"important":[9],"initial":[10],"reaction":[11],"in":[12,47,95,130],"a":[13,40,51,74],"host":[14],"defense":[15],"mechanism":[16],"against":[17],"cells.":[19],"The":[20,66],"authors":[21],"have":[22],"studied":[23],"cell":[24,43,56,58,72],"surface":[25],"components":[26],"of":[27,53,69,87,91,98,105,119,139,153],"human":[28,41,54],"esophageal":[29,63,144],"carcinoma":[30,57,145],"recognized":[32],"by":[33],"macrophages.":[34,154],"Superoxide":[35],"release":[36],"from":[37,62],"THP-1":[38],"cells,":[39],"macrophage":[42],"line,":[44,73],"was":[45,77,93,109],"analyzed":[46],"their":[48,113],"interaction":[49],"with":[50,81,117],"battery":[52],"squamous":[55],"lines":[59],"(TE)":[60],"originated":[61],"cancer":[64],"patients.":[65],"macrophage-triggering":[67,114],"ability":[68],"TE":[70,106],"1":[71,107],"high":[75],"stimulant,":[76],"reduced":[78],"after":[79],"treatment":[80],"trypsin":[82],"or":[83],"tunicamycin,":[84],"inhibitor":[86],"N-glycosidic":[88,131,140],"glycosylation.":[89],"Addition":[90],"monosaccharides":[92],"efficient":[94],"competitive":[96],"inhibition":[97],"these":[99],"cellular":[100],"interaction.":[101],"Moreover,":[102],"con-A-resistant":[103],"mutation":[104],"found":[110],"to":[111,124,149],"reduce":[112],"ability,":[115],"associated":[116],"increase":[118],"L-PHA-binding":[120],"capacity,":[121],"suggesting":[122],"substitution":[123],"the":[125,150],"GlcNAc":[126],"beta(1----6)-linked":[127],"lactosamine":[128],"antenna":[129],"carbohydrates.":[132],"These":[133],"findings":[134],"suggest":[135],"that":[136],"terminal":[137],"residues":[138],"carbohydrates":[141],"on":[142],"some":[143],"may":[147],"contribute":[148],"recognition":[151],"sites":[152]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}