{"id":"https://openalex.org/W165453396","doi":null,"title":"Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population.","display_name":"Association of apolipoprotein E 4 polymorphism with cerebral infarction in Chinese Han population.","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W165453396","mag":"165453396","pmid":"https://pubmed.ncbi.nlm.nih.gov/15000890"},"language":"en","primary_location":{"id":"pmid:15000890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063648977","display_name":"Zhu-qingJIN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu-qing Jin","raw_affiliation_strings":["Genomic Research Centre, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Research Centre, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056353865","display_name":"Yong-shengFAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-sheng Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053025522","display_name":"JingDING","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025845444","display_name":"MeiCHEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075707179","display_name":"WeiFan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071867216","display_name":"Guang-jiZHANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-ji Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049476485","display_name":"Bin-huiZHANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin-hui Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079588197","display_name":"Suo-jingYU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suo-jing Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017749420","display_name":"Yong-shengZHANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-sheng Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055789455","display_name":"Wei-fengJI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-feng Ji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jian-gang Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-gang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8646,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.86074299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"352","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.40059998631477356,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.40059998631477356,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.1923999935388565,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1453000009059906,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9769999980926514},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8019999861717224},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8840000033378601},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.7599999904632568},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7722159624099731},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.7438023686408997},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7251195907592773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6444377303123474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6257014870643616},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.47359374165534973},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43476665019989014},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.43353480100631714},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42821893095970154},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4194238483905792},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.41013437509536743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2366729974746704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17653819918632507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05190253257751465},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05176675319671631},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.04593825340270996},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15000890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:165453396","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95561A/200403/9650360.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:2418645915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W256414136","https://openalex.org/W1566107011","https://openalex.org/W1971310777","https://openalex.org/W1971735577","https://openalex.org/W1978665911","https://openalex.org/W1986806090","https://openalex.org/W2003418149","https://openalex.org/W2005710933","https://openalex.org/W2010165219","https://openalex.org/W2014253732","https://openalex.org/W2028395862","https://openalex.org/W2033077287","https://openalex.org/W2034363326","https://openalex.org/W2034968148","https://openalex.org/W2035278369","https://openalex.org/W2050738687","https://openalex.org/W2060803759","https://openalex.org/W2063951693","https://openalex.org/W2074999211","https://openalex.org/W2078776879","https://openalex.org/W2101898786","https://openalex.org/W2102602118","https://openalex.org/W2104565146","https://openalex.org/W2109568753","https://openalex.org/W2113173732","https://openalex.org/W2127230663","https://openalex.org/W2147462207","https://openalex.org/W2150000105","https://openalex.org/W2154838738","https://openalex.org/W2160209091","https://openalex.org/W2160993714","https://openalex.org/W2161260520","https://openalex.org/W2165820090","https://openalex.org/W2168909179","https://openalex.org/W3003397968"],"related_works":["https://openalex.org/W2789130834","https://openalex.org/W2378401969","https://openalex.org/W2068642004","https://openalex.org/W2363733599","https://openalex.org/W2369251741","https://openalex.org/W2371633748","https://openalex.org/W1131741312","https://openalex.org/W3031325187","https://openalex.org/W4200150249","https://openalex.org/W2380353561"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2,14],"the":[3,16,59,63,79,151,165,198,209,229],"association":[4],"between":[5],"APOE":[6,72,219],"polymorphisms":[7],"and":[8,44,69,89,110,126,139,146,160],"cerebral":[9,22,123,154,180,199,226],"infarction":[10,23,124,181,200,227],"through":[11],"a":[12,113,176,222],"case-control":[13],"among":[15,228],"Chinese":[17,46,230],"Han":[18,231],"population.":[19,232],"METHODS:":[20],"First-ever":[21],"patients":[24,152],"(n=226)":[25],"whose":[26],"ages":[27],"ranged":[28],"from":[29,37,58],"40":[30],"to":[31,190],"60":[32],"years":[33],"old":[34],"were":[35,56,129],"recruited":[36],"Department":[38],"of":[39,108,136,179,195],"Neurology,":[40],"Zhongshan":[41],"Hospital,":[42,49],"Shanghai,":[43],"Zhejiang":[45],"Traditional":[47],"Medicine":[48],"Zhejiang,":[50],"China.":[51],"Unrelated":[52],"healthy":[53,166],"controls":[54],"(n=201)":[55],"selected":[57],"general":[60],"population":[61],"in":[62,130,150,164,197,208],"same":[64],"area":[65],"with":[66,105,153,170],"similar":[67],"age":[68],"sex":[70],"distribution.":[71],"was":[73,102,141,203],"amplified":[74],"by":[75,112],"one-stage":[76],"PCR":[77,100],"using":[78],"forward":[80],"primer:":[81,91],"5'-GGC":[82],"ACG":[83],"GCT":[84,94],"GTC":[85],"CAA":[86],"GGA":[87],"GCT-3'":[88],"reverse":[90],"5'-GAT":[92],"GGC":[93],"GAG":[95],"GCC":[96],"GCG":[97],"CT-3'.":[98],"The":[99,133,192],"product":[101],"digested":[103],"directly":[104],"5":[106],"U":[107],"CfoI":[109],"separated":[111],"20":[114],"%":[115,148,162,186,213],"polyacrylamide":[116],"(acrylamide:":[117],"bis-acrylamide=29:1)":[118],"nondenaturing":[119],"gel.":[120],"RESULTS:":[121],"Both":[122],"patient":[125,201],"control":[127,167,210],"groups":[128],"Hardy-Weinberg":[131],"equilibrium.":[132],"allele":[134,193],"frequency":[135,194],"APOE*2,":[137],"APOE*3,":[138],"APOE*4":[140,196],"4.6":[142],"%,":[143,145,157,159],"81.9":[144],"13.5":[147],"respectively":[149,163],"infarction;":[155],"5.7":[156],"87.3":[158],"7.0":[161,215],"group.":[168],"Compared":[169],"APOE3/3":[171],"subjects,":[172],"APOE4/4":[173],"carriers":[174],"had":[175],"2.1-fold":[177],"risk":[178,223],"(odds":[182],"ratio":[183],"2.1,":[184],"95":[185],"confidence":[187],"limits":[188],"1.3":[189],"3.4).":[191],"group":[202,211],"significantly":[204],"higher":[205],"than":[206],"that":[207],"(13.5":[212],"vs":[214],"%;":[216],"P=0.002).":[217],"CONCLUSION:":[218],"4":[220],"is":[221],"factor":[224],"for":[225]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
