{"id":"https://openalex.org/W1653385306","doi":"https://doi.org/10.4049/jimmunol.138.2.582","title":"Modulation of the macrophage oxidative burst by Histoplasma capsulatum.","display_name":"Modulation of the macrophage oxidative burst by Histoplasma capsulatum.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W1653385306","doi":"https://doi.org/10.4049/jimmunol.138.2.582","mag":"1653385306","pmid":"https://pubmed.ncbi.nlm.nih.gov/3025301"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.138.2.582","doi":"https://doi.org/10.4049/jimmunol.138.2.582","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.138.2.582","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112041938","display_name":"J. E. Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Wolf","raw_affiliation_strings":["Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042007421","display_name":"V Kerchberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Kerchberger","raw_affiliation_strings":["Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112772975","display_name":"G S Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Kobayashi","raw_affiliation_strings":["Department of Laboratory Medicine, Washington University School of Medicine , St. Louis, MO 63110","Departments of Medicine, Microbiology, and Immunology, Washington University School of Medicine , St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Departments of Medicine, Microbiology, and Immunology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":null,"display_name":"J R Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Little","raw_affiliation_strings":["Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110","Departments of Medicine, Microbiology, and Immunology, Washington University School of Medicine , St. Louis, MO 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine at the Jewish Hospital, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Departments of Medicine, Microbiology, and Immunology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4635,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.82499621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"138","issue":"2","first_page":"582","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histoplasma-capsulatum","display_name":"Histoplasma capsulatum","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.9279999732971191},{"id":"https://openalex.org/keywords/antibody-opsonization","display_name":"antibody opsonization","score":0.8169999718666077},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C99971728","wikidata":"https://www.wikidata.org/wiki/Q838181","display_name":"Respiratory burst","level":2,"score":0.8716855049133301},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.866798460483551},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.8435389995574951},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7678048014640808},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7101338505744934},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.6804693937301636},{"id":"https://openalex.org/C2777802930","wikidata":"https://www.wikidata.org/wiki/Q10941019","display_name":"Histoplasma","level":4,"score":0.5979316234588623},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5872874855995178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5846649408340454},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5596900582313538},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.46124663949012756},{"id":"https://openalex.org/C2778803964","wikidata":"https://www.wikidata.org/wiki/Q143747","display_name":"Histoplasma capsulatum","level":3,"score":0.26659345626831055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25594234466552734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21009919047355652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1694960594177246},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15396159887313843},{"id":"https://openalex.org/C2780318139","wikidata":"https://www.wikidata.org/wiki/Q627625","display_name":"Histoplasmosis","level":2,"score":0.06005871295928955}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006658","descriptor_name":"Histoplasma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006660","descriptor_name":"Histoplasmosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.138.2.582","doi":"https://doi.org/10.4049/jimmunol.138.2.582","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.138.2.582","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:3025301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3025301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356912268","display_name":"LYMPHOCYTE ACTIVATION, MATURATION AND FUNCTION","funder_award_id":"P01AI015353","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8725122132","display_name":"MEDICAL MYCOLOGY","funder_award_id":"P01AI016228","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1854426882","https://openalex.org/W1955262316","https://openalex.org/W2136638816","https://openalex.org/W2222782003","https://openalex.org/W1439576401","https://openalex.org/W1498013989","https://openalex.org/W1585809398","https://openalex.org/W7097090321","https://openalex.org/W2156379593","https://openalex.org/W2153813895"],"abstract_inverted_index":{"The":[0],"production":[1],"of":[2,36,52,63,81,85,106,112,116,134],"reactive":[3,26,53],"oxygen":[4,54],"species":[5],"by":[6,25,98],"phagocytic":[7],"cells":[8],"is":[9],"an":[10],"important":[11],"host":[12],"defense":[13],"against":[14],"invading":[15],"microorganisms.":[16,65],"Because":[17],"pathogens":[18],"that":[19,132],"achieve":[20],"intracellular":[21,34],"survival":[22,35],"escape":[23],"destruction":[24],"oxidants,":[27],"we":[28],"investigated":[29],"the":[30,33,40,50,64,122,135],"relationship":[31],"between":[32],"H.":[37,44,90,117],"capsulatum":[38,45,91,118],"and":[39],"macrophage":[41],"oxidative":[42,107],"burst.":[43],"yeast":[46,119],"failed":[47],"to":[48],"stimulate":[49],"release":[51],"metabolites":[55],"in":[56,104,127],"unprimed":[57],"murine":[58,86],"macrophages":[59,87],"despite":[60],"extensive":[61],"phagocytosis":[62],"This":[66],"effect":[67],"was":[68],"observed":[69],"with":[70,88,94,100,121],"live":[71],"as":[72,74],"well":[73],"heat-killed":[75,89],"fungi":[76],"over":[77],"a":[78],"wide":[79],"range":[80],"yeast-to-macrophage":[82],"ratios.":[83],"Preincubation":[84],"(but":[92],"not":[93],"latex":[95],"spheres),":[96],"followed":[97],"incubation":[99],"unopsonized":[101],"zymosan,":[102],"resulted":[103,126],"inhibition":[105,111],"burst":[108,137],"triggering":[109],"without":[110],"zymosan":[113],"phagocytosis.":[114,143],"Ingestion":[115],"opsonized":[120],"cognate":[123],"mouse":[124],"antibody":[125],"significant":[128],"oxidant":[129],"release,":[130],"suggesting":[131],"suppression":[133],"respiratory":[136],"may":[138],"be":[139],"circumvented":[140],"through":[141],"Fc-mediated":[142]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
