{"id":"https://openalex.org/W1651982135","doi":null,"title":"Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.","display_name":"Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.","publication_year":1996,"publication_date":"1996-02-15","ids":{"openalex":"https://openalex.org/W1651982135","mag":"1651982135","pmid":"https://pubmed.ncbi.nlm.nih.gov/8631014"},"language":"en","primary_location":{"id":"pmid:8631014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083640936","display_name":"Michael Belanich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Belanich","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York 11520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York 11520, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109207041","display_name":"Monica Pastor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Pastor","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034035869","display_name":"Terri Randall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Randall","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Guerra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Guerra","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031516740","display_name":"Jeannie Tsimis Kibitel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kibitel","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003993408","display_name":"Lori Alas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Alas","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024533924","display_name":"Ben Li","orcid":"https://orcid.org/0000-0002-6577-1872","observed_orcids":["https://orcid.org/0000-0002-6577-1872"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"B Li","raw_affiliation_strings":["National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046252848","display_name":"Marc L. Citron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Citron","raw_affiliation_strings":["North Shore Long Island Jewish Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Long Island Jewish Health System","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041490581","display_name":"Patricia Wasserman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Wasserman","raw_affiliation_strings":["North Shore Long Island Jewish Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Long Island Jewish Health System","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084043746","display_name":"A White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A White","raw_affiliation_strings":["North Shore Long Island Jewish Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Long Island Jewish Health System","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112818113","display_name":"Harmon J. Eyre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288198617","display_name":"American Cancer Society","ror":"https://ror.org/02e463172","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1288198617"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Eyre","raw_affiliation_strings":["American Cancer Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Cancer Society","institution_ids":["https://openalex.org/I1288198617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657472","display_name":"Kurt A. Jaeckle","orcid":"https://orcid.org/0000-0002-7827-463X","observed_orcids":["https://orcid.org/0000-0002-7827-463X"]},"institutions":[{"id":"https://openalex.org/I2802646204","display_name":"Morristown Medical Center","ror":"https://ror.org/03m6tev69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802646204","https://openalex.org/I67339987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Jaeckle","raw_affiliation_strings":["Morristown Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morristown Medical Center","institution_ids":["https://openalex.org/I2802646204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038766696","display_name":"Susan Schulman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Schulman","raw_affiliation_strings":["University of Utah,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah,","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081476985","display_name":"D J Rector","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Rector","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264008","display_name":"Michael D. Prados","orcid":"https://orcid.org/0000-0002-9630-2075","observed_orcids":["https://orcid.org/0000-0002-9630-2075"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Prados","raw_affiliation_strings":["University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013573655","display_name":"Stephen William Coons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325481341","display_name":"St. Joseph's Hospital and Medical Center","ror":"https://ror.org/00m72wv30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Coons","raw_affiliation_strings":["St. Joseph\u2019s Hospital and Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Joseph\u2019s Hospital and Medical Center","institution_ids":["https://openalex.org/I1325481341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112140963","display_name":"William Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325481341","display_name":"St. Joseph's Hospital and Medical Center","ror":"https://ror.org/00m72wv30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325481341","https://openalex.org/I2802827176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Shapiro","raw_affiliation_strings":["St. Joseph\u2019s Hospital and Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Joseph\u2019s Hospital and Medical Center","institution_ids":["https://openalex.org/I1325481341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015232791","display_name":"Daniel B. Yarosh","orcid":"https://orcid.org/0000-0002-0786-5985","observed_orcids":["https://orcid.org/0000-0002-0786-5985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Yarosh","raw_affiliation_strings":["Applied Genetics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.167,"has_fulltext":false,"cited_by_count":244,"citation_normalized_percentile":{"value":0.92277973,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"56","issue":"4","first_page":"783","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o6-methylguanine-dna-methyltransferase","display_name":"O6-methylguanine-DNA methyltransferase","score":0.968999981880188},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6890000104904175},{"id":"https://openalex.org/keywords/carmustine","display_name":"BCNU","score":0.9139999747276306},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7350000143051147},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7459999918937683},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tumor-subpopulations","display_name":"tumor cell subpopulations","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780147359","wikidata":"https://www.wikidata.org/wiki/Q415869","display_name":"Carmustine","level":4,"score":0.9602298736572266},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5969864726066589},{"id":"https://openalex.org/C2776946711","wikidata":"https://www.wikidata.org/wiki/Q418311","display_name":"Nitrosourea","level":3,"score":0.588792622089386},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5632041096687317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38510116934776306},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36237138509750366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29302501678466797},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2909678816795349},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20901444554328918},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.10494032502174377}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002330","descriptor_name":"Carmustine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019853","descriptor_name":"O(6)-Methylguanine-DNA Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8631014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Clinical Trial"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/130556","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/130556","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"mag:1651982135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8631014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006338926","https://openalex.org/W2075623636","https://openalex.org/W2114905010","https://openalex.org/W1993331812","https://openalex.org/W2130565778","https://openalex.org/W2431402097","https://openalex.org/W2059888592","https://openalex.org/W2396549701","https://openalex.org/W1966947892","https://openalex.org/W2060256286"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,5,8,86,89,107,158],"hypothesis":[3],"that":[4],"level":[6],"of":[7,56,88,91,96,116,161],"DNA":[9],"repair":[10],"protein":[11],"O6-alkylguanine-DNA":[12],"alkyltransferase":[13,57,83,97,123,134,147],"in":[14,27,30,114],"brain":[15,35,154],"tumors":[16,36,106],"was":[17,98,129],"correlated":[18,99,111,132],"with":[19,38,42,53,81,93,101,112,133,137,157],"resistance":[20],"to":[21,61,145,163],"carmustine":[22],"(BCNU)":[23],"chemotherapy.":[24,165],"Alkyltransferase":[25],"levels":[26,55,95,135,148],"individual":[28],"cells":[29,92],"sections":[31],"from":[32],"167":[33],"primary":[34],"treated":[37],"BCNU":[39,164],"were":[40,118],"quantitated":[41],"an":[43],"immunofluorescence":[44],"assay":[45],"using":[46],"monoclonal":[47],"antibodies":[48],"against":[49],"human":[50],"alkyltransferase.":[51],"Patients":[52],"high":[54,94],"had":[58],"shorter":[59],"time":[60],"treatment":[62],"failure":[63],"(P":[64,69],"=":[65,70],"0.05)":[66],"and":[67,72,122],"death":[68,74],"0.004)":[71],"a":[73,150],"rate":[75],"1.7":[76],"times":[77],"greater":[78],"than":[79,136],"patients":[80,156],"low":[82],"levels.":[84,124],"Furthermore,":[85],"size":[87],"subpopulation":[90],"directly":[100],"drug":[102],"resistance.":[103],"For":[104,125],"all":[105],"variables":[108],"most":[109],"closely":[110],"survival,":[113],"order":[115],"importance,":[117],"age,":[119],"tumor":[120,155],"grade,":[121],"glioblastoma":[126],"multiforme,":[127],"survival":[128],"more":[130],"strongly":[131],"age.":[138],"These":[139],"results":[140],"should":[141],"encourage":[142],"prospective":[143],"studies":[144],"evaluate":[146],"as":[149],"method,":[151],"for":[152],"identifying":[153],"best":[159],"likelihood":[160],"response":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}