{"id":"https://openalex.org/W164904491","doi":null,"title":"Sequential combination of methotrexate and L-asparaginase in the treatment of refractory acute leukemia.","display_name":"Sequential combination of methotrexate and L-asparaginase in the treatment of refractory acute leukemia.","publication_year":1980,"publication_date":"1980-08-01","ids":{"openalex":"https://openalex.org/W164904491","mag":"164904491","pmid":"https://pubmed.ncbi.nlm.nih.gov/6934851"},"language":"en","primary_location":{"id":"pmid:6934851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6934851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080855457","display_name":"Sergio Amadori","orcid":"https://orcid.org/0000-0002-2356-8681","observed_orcids":["https://orcid.org/0000-0002-2356-8681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Amadori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038215860","display_name":"M Tribalto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tribalto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082653261","display_name":"L Pacilli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Pacilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055554018","display_name":"De Laurentis C","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C De Laurentis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109172617","display_name":"G Papa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Papa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105419329","display_name":"Franco Mandelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Mandelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6641,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.66761459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"64","issue":"8-9","first_page":"939","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.09109999984502792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-acute-leukemia","display_name":"refractory acute leukemia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.972000002861023},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":1.0},{"id":"https://openalex.org/keywords/sequential-combination-chemotherapy","display_name":"sequential combination chemotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.878000020980835},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9396281242370605},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.804807722568512},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7261958122253418},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5976358652114868},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.597303032875061},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5824158787727356},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5545234680175781},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5456538796424866},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.5388064384460449},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.53812575340271},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.4898333251476288},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4857945442199707},{"id":"https://openalex.org/C2779051857","wikidata":"https://www.wikidata.org/wiki/Q911386","display_name":"Stomatitis","level":2,"score":0.4547847509384155},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.24393340945243835},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001215","descriptor_name":"Asparaginase","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007945","descriptor_name":"Leukemia, Lymphoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6934851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6934851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},{"id":"mag:164904491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6934851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409658010","https://openalex.org/W2060841268","https://openalex.org/W2626751287","https://openalex.org/W2466424044","https://openalex.org/W2439643660","https://openalex.org/W1984473957","https://openalex.org/W2005614502","https://openalex.org/W2115731755","https://openalex.org/W2043685977","https://openalex.org/W2044209276"],"abstract_inverted_index":{"Seventy-six":[0],"patients":[1,41,81,98,110],"with":[2,12,66,74,99,111,135],"advanced":[3],"acute":[4,100,112,155,196],"leukemia":[5,102,114],"refractory":[6,195],"to":[7,124,158,175],"conventional":[8],"chemotherapy":[9],"were":[10],"treated":[11],"a":[13,55,87,144,188],"sequential":[14],"combination":[15,138,186],"of":[16,45,57,72,79,89,104,116,122,148],"methotrexate":[17],"(MTX)":[18],"and":[19,107,165],"L-asparaginase":[20],"(L-ASP),":[21],"based":[22],"on":[23],"the":[24,29,70,92,119,130,136,184],"reported":[25],"schedule-dependent":[26],"synergism":[27],"between":[28],"two":[30],"drugs":[31],"in":[32,36,69,97,109,172],"human":[33],"leukemic":[34],"cells":[35],"vitro.":[37],"On":[38],"Day":[39],"1,":[40],"received":[42],"60":[43],"mg/m2":[44,126,177],"MTX":[46,73,123,171],"iv,":[47],"followed":[48],"24":[49],"hours":[50],"later":[51],"by":[52],"L-ASP":[53,159],"at":[54],"dose":[56,71,121],"10,000":[58],"IU/m2":[59],"iv.":[60],"This":[61],"sequence":[62],"was":[63,95,152],"repeated":[64],"weekly":[65],"50%":[67],"escalations":[68],"each":[75],"course.":[76],"Overall,":[77],"31":[78],"76":[80],"(40.7%)":[82],"achieved":[83],"complete":[84,146],"remission":[85,147],"after":[86],"median":[88,145],"three":[90],"courses;":[91],"response":[93,131],"rate":[94],"35.5%":[96],"nonlymphocytic":[101],"(21":[103],"59":[105],"patients)":[106],"58.8%":[108],"lymphocytic":[113],"(ten":[115],"17).":[117],"Increasing":[118],"starting":[120],"200":[125,176],"did":[127],"not":[128],"improve":[129],"rate.":[132],"Maintenance":[133],"therapy":[134],"same":[137],"given":[139],"every":[140],"2":[141],"weeks":[142],"produced":[143],"10":[149],"weeks.":[150],"Toxicity":[151],"manifested":[153],"by:":[154],"hypersensitivity":[156],"reactions":[157],"(five":[160,169],"patients),":[161,164],"stomatitis":[162],"(36":[163],"mild":[166],"liver":[167],"abnormalities":[168],"patients).":[170],"doses":[173],"up":[174],"caused":[178],"minimal":[179],"myelosuppression.":[180],"We":[181],"conclude":[182],"that":[183],"MTX-L-ASP":[185],"is":[187],"well-tolerated,":[189],"highly":[190],"effective":[191],"induction":[192],"regimen":[193],"for":[194],"leukemia.":[197]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}