{"id":"https://openalex.org/W1648485202","doi":null,"title":"ARRAY COMPARATIVE GENOMIC HYBRIDIZATION IN SARCOMAS","display_name":"ARRAY COMPARATIVE GENOMIC HYBRIDIZATION IN SARCOMAS","publication_year":2007,"publication_date":"2007-06-15","ids":{"openalex":"https://openalex.org/W1648485202","mag":"1648485202"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20436","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20436","pdf_url":"http://hdl.handle.net/10138/20436","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/20436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081360033","display_name":"Sippy Kaur","orcid":"https://orcid.org/0000-0002-4371-1959","observed_orcids":["https://orcid.org/0000-0002-4371-1959"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sippy Kaur","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4371-1959","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081360033"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.8349999785423279},{"id":"https://openalex.org/keywords/soft-tissue-leiomyosarcoma","display_name":"soft tissue leiomyosarcoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dermatofibrosarcoma-protuberans","display_name":"dermatofibrosarcoma protuberans","score":0.9819999933242798},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/malignant-fibrous-histiocytoma","display_name":"malignant fibrous histiocytoma","score":1.0},{"id":"https://openalex.org/keywords/uterine-leiomyosarcoma","display_name":"uterine leiomyosarcoma","score":1.0},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/17q-gain","display_name":"17q gain","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.92656409740448},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6645199060440063},{"id":"https://openalex.org/C2777532014","wikidata":"https://www.wikidata.org/wiki/Q1504713","display_name":"Leiomyosarcoma","level":2,"score":0.6431294679641724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5875451564788818},{"id":"https://openalex.org/C2778464197","wikidata":"https://www.wikidata.org/wiki/Q1200239","display_name":"Dermatofibrosarcoma protuberans","level":2,"score":0.5775916576385498},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.532423734664917},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.48951494693756104},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.44635212421417236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33517569303512573},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2965126037597656},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2809792160987854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2720889449119568},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2470664083957672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1757166087627411},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1530802845954895}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/20436","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20436","pdf_url":"http://hdl.handle.net/10138/20436","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1648485202","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/20436/1/arraycom.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20436","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20436","pdf_url":"http://hdl.handle.net/10138/20436","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1648485202.pdf","grobid_xml":"https://content.openalex.org/works/W1648485202.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W81826961","https://openalex.org/W83261268","https://openalex.org/W115673842","https://openalex.org/W139841376","https://openalex.org/W145574908","https://openalex.org/W146169576","https://openalex.org/W307897316","https://openalex.org/W1484187172","https://openalex.org/W1484593295","https://openalex.org/W1507117943","https://openalex.org/W1517116833","https://openalex.org/W1520403286","https://openalex.org/W1529319215","https://openalex.org/W1535584123","https://openalex.org/W1540592419","https://openalex.org/W1544851750","https://openalex.org/W1546186502","https://openalex.org/W1550594329","https://openalex.org/W1556555576","https://openalex.org/W1559320158","https://openalex.org/W1562829802","https://openalex.org/W1592526217","https://openalex.org/W1595661151","https://openalex.org/W1596054952","https://openalex.org/W1608544625","https://openalex.org/W1783699960","https://openalex.org/W1858648870","https://openalex.org/W1909097318","https://openalex.org/W1921671511","https://openalex.org/W1931311635","https://openalex.org/W1964729637","https://openalex.org/W1965054867","https://openalex.org/W1966586745","https://openalex.org/W1968046362","https://openalex.org/W1968847307","https://openalex.org/W1972072858","https://openalex.org/W1973315860","https://openalex.org/W1976059757","https://openalex.org/W1979778204","https://openalex.org/W1979849852","https://openalex.org/W1979909416","https://openalex.org/W1980255554","https://openalex.org/W1980548655","https://openalex.org/W1981719599","https://openalex.org/W1981872831","https://openalex.org/W1983811810","https://openalex.org/W1985379210","https://openalex.org/W1987239234","https://openalex.org/W1987246494","https://openalex.org/W1988812015","https://openalex.org/W1988823481","https://openalex.org/W1989224324","https://openalex.org/W1989742687","https://openalex.org/W1994419156","https://openalex.org/W1995504862","https://openalex.org/W1998257800","https://openalex.org/W2001205379","https://openalex.org/W2001564888","https://openalex.org/W2002079712","https://openalex.org/W2002452610","https://openalex.org/W2003778471","https://openalex.org/W2005542290","https://openalex.org/W2007012192","https://openalex.org/W2007366502","https://openalex.org/W2007733980","https://openalex.org/W2011683291","https://openalex.org/W2013892708","https://openalex.org/W2014401442","https://openalex.org/W2015452754","https://openalex.org/W2016129578","https://openalex.org/W2018069599","https://openalex.org/W2018556770","https://openalex.org/W2019021865","https://openalex.org/W2020617188","https://openalex.org/W2021635658","https://openalex.org/W2022452100","https://openalex.org/W2023706289","https://openalex.org/W2024129238","https://openalex.org/W2024595229","https://openalex.org/W2025112578","https://openalex.org/W2025527937","https://openalex.org/W2029851254","https://openalex.org/W2032118557","https://openalex.org/W2032163170","https://openalex.org/W2033835727","https://openalex.org/W2033896256","https://openalex.org/W2035776539","https://openalex.org/W2037100222","https://openalex.org/W2038586922","https://openalex.org/W2038593366","https://openalex.org/W2039356250","https://openalex.org/W2039722727","https://openalex.org/W2040316588","https://openalex.org/W2045952235","https://openalex.org/W2046841776","https://openalex.org/W2046853984","https://openalex.org/W2047703254","https://openalex.org/W2047715978","https://openalex.org/W2048248253","https://openalex.org/W2048380916","https://openalex.org/W2048474354","https://openalex.org/W2049055469","https://openalex.org/W2055527138","https://openalex.org/W2056158616","https://openalex.org/W2059707627","https://openalex.org/W2060084956","https://openalex.org/W2060249724","https://openalex.org/W2060761276","https://openalex.org/W2064136894","https://openalex.org/W2065005324","https://openalex.org/W2068137385","https://openalex.org/W2068884609","https://openalex.org/W2069351898","https://openalex.org/W2069451020","https://openalex.org/W2072080668","https://openalex.org/W2073225422","https://openalex.org/W2073576377","https://openalex.org/W2074809432","https://openalex.org/W2076196494","https://openalex.org/W2077858999","https://openalex.org/W2078429149","https://openalex.org/W2078653071","https://openalex.org/W2079394734","https://openalex.org/W2081508278","https://openalex.org/W2083088781","https://openalex.org/W2084475506","https://openalex.org/W2084525187","https://openalex.org/W2085226758","https://openalex.org/W2085631326","https://openalex.org/W2086824056","https://openalex.org/W2087384554","https://openalex.org/W2092855637","https://openalex.org/W2094492618","https://openalex.org/W2095312888","https://openalex.org/W2097442664","https://openalex.org/W2097501009","https://openalex.org/W2098079931","https://openalex.org/W2101309602","https://openalex.org/W2102110450","https://openalex.org/W2102140136","https://openalex.org/W2102941013","https://openalex.org/W2103308950","https://openalex.org/W2105164182","https://openalex.org/W2106369700","https://openalex.org/W2108172661","https://openalex.org/W2109770623","https://openalex.org/W2110227850","https://openalex.org/W2113926943","https://openalex.org/W2114264186","https://openalex.org/W2114373487","https://openalex.org/W2115697887","https://openalex.org/W2116164911","https://openalex.org/W2116755958","https://openalex.org/W2118094114","https://openalex.org/W2118471037","https://openalex.org/W2119317141","https://openalex.org/W2119376406","https://openalex.org/W2121036637","https://openalex.org/W2122568674","https://openalex.org/W2125566310","https://openalex.org/W2126679757","https://openalex.org/W2126998655","https://openalex.org/W2127428399","https://openalex.org/W2130743654","https://openalex.org/W2130746209","https://openalex.org/W2130793549","https://openalex.org/W2132288466","https://openalex.org/W2135185276","https://openalex.org/W2136776097","https://openalex.org/W2137360734","https://openalex.org/W2139131750","https://openalex.org/W2139973326","https://openalex.org/W2140535402","https://openalex.org/W2140795153","https://openalex.org/W2141393790","https://openalex.org/W2141410747","https://openalex.org/W2143303362","https://openalex.org/W2143362349","https://openalex.org/W2143500395","https://openalex.org/W2143879406","https://openalex.org/W2144634347","https://openalex.org/W2145163296","https://openalex.org/W2145419979","https://openalex.org/W2146355396","https://openalex.org/W2146848960","https://openalex.org/W2147328076","https://openalex.org/W2148297520","https://openalex.org/W2149393207","https://openalex.org/W2150972461","https://openalex.org/W2151820600","https://openalex.org/W2151974707","https://openalex.org/W2153933760","https://openalex.org/W2154099481","https://openalex.org/W2154352356","https://openalex.org/W2154361640","https://openalex.org/W2155502787","https://openalex.org/W2155513152","https://openalex.org/W2155707112","https://openalex.org/W2156643308","https://openalex.org/W2159064969","https://openalex.org/W2159512050","https://openalex.org/W2161667408","https://openalex.org/W2161721798","https://openalex.org/W2163258576","https://openalex.org/W2164976222","https://openalex.org/W2166207067","https://openalex.org/W2166454117","https://openalex.org/W2167424472","https://openalex.org/W2167649358","https://openalex.org/W2167673013","https://openalex.org/W2170179136","https://openalex.org/W2170229434","https://openalex.org/W2170967347","https://openalex.org/W2171454878","https://openalex.org/W2181414232","https://openalex.org/W2202691910","https://openalex.org/W2317242660","https://openalex.org/W2317783677","https://openalex.org/W2330923897","https://openalex.org/W2342102040","https://openalex.org/W2402970027","https://openalex.org/W2409304774","https://openalex.org/W2418976672","https://openalex.org/W2419098744","https://openalex.org/W2465716927","https://openalex.org/W2512906422","https://openalex.org/W2569020266","https://openalex.org/W2768021705","https://openalex.org/W2769112105","https://openalex.org/W3143166964","https://openalex.org/W3191919454","https://openalex.org/W4233326795","https://openalex.org/W7098325675"],"related_works":["https://openalex.org/W1971876346","https://openalex.org/W7095479033","https://openalex.org/W2465012582","https://openalex.org/W1964366999","https://openalex.org/W2010866230","https://openalex.org/W2314249428","https://openalex.org/W6959548037","https://openalex.org/W2146611892","https://openalex.org/W1596283759","https://openalex.org/W2011671698"],"abstract_inverted_index":{"Over":[0],"the":[1,21,28,33,46,85,147,234,280,371,383,389],"past":[2],"years,":[3],"much":[4],"research":[5],"on":[6,9],"sarcomas":[7,386],"based":[8],"low-resolution":[10],"cytogenetic":[11,14],"and":[12,61,66,101,117,136,165,190,194,211,215,240,256,262,273,283,321,324,334,397],"molecular":[13],"methods":[15],"has":[16,378],"been":[17,350,409],"published,":[18],"leading":[19],"to":[20,75,128,279],"identification":[22,34],"of":[23,35,71,87,134,149,228,237,252,269,316,327,336,385],"genetic":[24,36],"abnormalities":[25],"partially":[26],"underlying":[27],"tumourigenesis.":[29],"Continued":[30],"progress":[31],"in":[32,84,126,162,182,199,209,287,311,319,332,344,367,375],"events":[37],"such":[38],"as":[39,246],"copy":[40,78,123,176,253,270,297,329,341,364,394],"number":[41,79,124,177,254,271,298,330,342,365,395],"aberrations":[42,139],"relies":[43],"upon":[44],"adapting":[45],"rapidly":[47],"evolving":[48],"high-resolution":[49],"microarray":[50],"technology,":[51,355],"which":[52,144,406],"will":[53],"eventually":[54],"provide":[55],"novel":[56,308],"insights":[57,381],"into":[58,382],"sarcoma":[59],"biology,":[60],"targets":[62],"for":[63],"both":[64],"diagnostics":[65],"drug":[67],"development.":[68],"The":[69,201,306],"aim":[70],"this":[72,222,312,357,376],"Thesis":[73,358,377],"was":[74,205],"characterize":[76],"DNA":[77,328,363],"changes":[80,299,331,343,366,396],"that":[81],"are":[82],"involved":[83],"pathogenesis":[86],"soft":[88],"tissue":[89],"leiomyosarcoma":[90,103],"(LMS),":[91],"dermatofibrosarcoma":[92],"protuberans":[93],"(DFSP),":[94],"osteosarcoma":[95],"(OS),":[96],"malignant":[97],"fibrous":[98],"histiocytoma":[99],"(MFH),":[100],"uterine":[102],"(ULMS)":[104],"by":[105,142,158,184,207,289,295,303,340,353,387,393,411],"applying":[106],"fine":[107],"resolution":[108,148,415],"array":[109],"comparative":[110,151],"genomic":[111,152],"hybridization":[112,153],"(aCGH)":[113],"technology.":[114],"Both":[115],"low-":[116,210,320],"high-grade":[118,212,241,322],"LMS":[119,242,264,323],"tumours":[120,156],"showed":[121,160,248,265],"distinct":[122],"patterns,":[125],"addition":[127,278],"sharing":[129],"two":[130],"minimal":[131,225],"common":[132,226],"regions":[133,227,285,391],"gains":[135,161,229,255,272],"losses.":[137],"Small":[138],"were":[140,145,186,196,243,300],"detected":[141],"aCGH,":[143,290],"beyond":[146],"chromosomal":[150],"(cCGH).":[154],"DFSP":[155],"analysed":[157],"aCGH":[159,185,208,354,372],"17q,":[163],"22q,":[164],"21":[166],"additional":[167],"gained":[168,282],"regions,":[169,405],"but":[170,219],"only":[171],"one":[172,220],"region":[173],"(22q)":[174],"with":[175,224,233],"loss.":[178],"Recurrent":[179],"amplicons":[180],"identified":[181,286],"OS":[183,239],"12q11-q15,":[187],"8q,":[188],"6p12-p21,":[189],"17p.":[191,276],"Amplicons":[192],"12q":[193],"17p":[195,204,318],"further":[197],"characterized":[198,206],"detail.":[200],"amplicon":[202,317],"at":[203,230,258,275],"LMS,":[213,333],"OS,":[214],"MFH.":[216],"In":[217,277,369],"all":[218],"case":[221],"amplicon,":[223],"17p11-p12,":[231],"started":[232],"distal":[235],"loss":[236],"17p13-pter.":[238],"grouped":[244],"together":[245],"they":[247],"a":[249,266],"complex":[250],"pattern":[251,268],"amplifications":[257],"17p,":[259],"whereas":[260],"MFH":[261],"low-grade":[263],"continuous":[267],"amplification":[274],"commonly":[281],"lost":[284],"ULMS":[288],"various":[291,337],"biological":[292],"processes":[293],"affected":[294,339,392],"these":[296],"also":[301],"indicated":[302],"pathway":[304],"analysis.":[305],"three":[307],"findings":[309],"obtained":[310],"work":[313],"were:":[314],"characterization":[315],"MFH,":[325],"profiles":[326],"detection":[335],"pathways":[338],"ULMS.":[345],"These":[346],"studies":[347],"have":[348],"not":[349,408],"undertaken":[351],"previously":[352,412],"thus":[356],"adds":[359],"new":[360,380],"information":[361],"regarding":[362],"sarcomas.":[368],"conclusion,":[370],"technique":[373],"used":[374],"provided":[379],"genetics":[384],"detecting":[388],"precise":[390],"some":[398],"potential":[399],"candidate":[400],"target":[401],"genes":[402],"within":[403],"those":[404],"had":[407],"uncovered":[410],"applied":[413],"low":[414],"techniques.":[416]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
