{"id":"https://openalex.org/W164757458","doi":null,"title":"Chronic antigen-antibody-complex glomerulonephritis in mice.","display_name":"Chronic antigen-antibody-complex glomerulonephritis in mice.","publication_year":1981,"publication_date":"1981-12-01","ids":{"openalex":"https://openalex.org/W164757458","mag":"164757458","pmid":"https://pubmed.ncbi.nlm.nih.gov/6459798","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041725"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2041725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041725","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041725","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111735797","display_name":"Michael W Steward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M W Steward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M J Collins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Collins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009028392","display_name":"Carolynne M. Stanley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Stanley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062186168","display_name":"Madeleine E. Devey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Devey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5199,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61785498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"62","issue":"6","first_page":"614","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-affinity-antibodies","display_name":"low-affinity antibodies","score":0.6740000247955322},{"id":"https://openalex.org/keywords/high-affinity-antibodies","display_name":"high-affinity antibodies","score":0.7919999957084656},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.37599998712539673},{"id":"https://openalex.org/keywords/subepithelial-deposits","display_name":"subepithelial deposits","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mesangial-deposits","display_name":"mesangial deposits","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mouse-strain-differences","display_name":"mouse strain differences","score":0.3370000123977661},{"id":"https://openalex.org/keywords/chronic-glomerulonephritis","display_name":"chronic glomerulonephritis","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8086302876472473},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7031104564666748},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.6109830737113953},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.555300772190094},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.518571674823761},{"id":"https://openalex.org/C2908797038","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Antigen-Antibody Complex","level":3,"score":0.5081145763397217},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.49746373295783997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4619695544242859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38787713646888733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3124117851257324},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3064737617969513},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.28653156757354736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1845102608203888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13276627659797668}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005921","descriptor_name":"Glomerulonephritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007105","descriptor_name":"Immune Complex Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007105","descriptor_name":"Immune Complex Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2041725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041725","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},{"id":"pmid:6459798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6459798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of experimental pathology","raw_type":"Journal Article"},{"id":"mag:164757458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6459798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2041725","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041725","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1487638043","https://openalex.org/W1587041382","https://openalex.org/W1998542409","https://openalex.org/W2047855936","https://openalex.org/W2093352141","https://openalex.org/W2407214801","https://openalex.org/W2411103057","https://openalex.org/W2416491170","https://openalex.org/W2417875797","https://openalex.org/W2443674589"],"related_works":["https://openalex.org/W2411103057","https://openalex.org/W2416491170","https://openalex.org/W2417875797","https://openalex.org/W2091896452","https://openalex.org/W2415599137","https://openalex.org/W1568160055","https://openalex.org/W204037863","https://openalex.org/W1530910736","https://openalex.org/W2407376751","https://openalex.org/W2166310345"],"abstract_inverted_index":{"Daily":[0],"injection":[1],"of":[2,36,42,49,57,62,95,101],"human":[3],"serum":[4],"albumin":[5],"into":[6],"mice":[7,26,32,68,75,85,91],"genetically":[8],"selected":[9],"to":[10,14,52,78],"produce":[11],"low-affinity":[12,31,67,84],"antibody":[13],"protein":[15],"antigens":[16],"resulted":[17],"in":[18,25,66,73,83,89,103],"a":[19],"more":[20],"severe":[21],"antigen-antibody-complex-induced":[22],"glomerulonephritis":[23],"than":[24],"producing":[27],"high-affinity":[28,53,74,90],"antibody.":[29],"The":[30],"had":[33],"higher":[34],"levels":[35],"circulating":[37],"antigen-antibody":[38],"complexes,":[39],"greater":[40],"impairment":[41],"renal":[43],"function":[44],"and":[45,69,86],"reduced":[46],"reticuloendothelial":[47],"clearance":[48],"125I-PVP":[50],"compared":[51],"mice.":[54],"Electron":[55],"microscopy":[56],"glomeruli":[58],"revealed":[59],"the":[60,79,99,104],"presence":[61,100],"subepithelial":[63],"electron-dense":[64,105],"deposits":[65,72,110],"predominantly":[70,80],"subendothelial-mesangial":[71],"which":[76],"corresponded":[77],"capillary":[81],"staining":[82,88],"mesangial":[87],"by":[92],"immunofluorescence.":[93],"Auto-radiography":[94],"electron-microscopy":[96],"sections":[97],"demonstrated":[98],"antigen":[102],"deposits,":[106],"indicating":[107],"that":[108],"these":[109],"indeed":[111],"contained":[112],"antigen-antigen":[113],"complexes.":[114]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}