{"id":"https://openalex.org/W1647337374","doi":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","title":"Thrombospondin\u20101 is an inhibitor of pharmacological activation of soluble guanylate cyclase","display_name":"Thrombospondin\u20101 is an inhibitor of pharmacological activation of soluble guanylate cyclase","publication_year":2010,"publication_date":"2010-03-03","ids":{"openalex":"https://openalex.org/W1647337374","doi":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","mag":"1647337374","pmid":"https://pubmed.ncbi.nlm.nih.gov/20233213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2850410"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.2009.00631.x","doi":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2009.00631.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2009.00631.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043468096","display_name":"Thomas W. Miller","orcid":"https://orcid.org/0000-0001-8645-2785","observed_orcids":["https://orcid.org/0000-0001-8645-2785"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas W Miller","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA","Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090250366","display_name":"Jeff S. Isenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff S Isenberg","raw_affiliation_strings":["Vascular Medicine Institute of the University of Pittsburgh, the Department of Medicine, and the Department of Pharmacology and Chemical Biology of the University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Medicine Institute of the University of Pittsburgh, the Department of Medicine, and the Department of Pharmacology and Chemical Biology of the University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031078822","display_name":"David D. Roberts","orcid":"https://orcid.org/0000-0002-2481-2981","observed_orcids":["https://orcid.org/0000-0002-2481-2981"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David D Roberts","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031078822"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":4.7645,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94720143,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"159","issue":"7","first_page":"1542","last_page":"1547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":1.0},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sgc-activators","display_name":"sGC activators","score":0.7699999809265137},{"id":"https://openalex.org/keywords/yc-1","display_name":"YC-1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bay-41-2272","display_name":"BAY 41-2272","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.5870000123977661},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-contraction","display_name":"vascular smooth muscle contraction","score":0.968999981880188},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6150000095367432},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.6318265795707703},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6291279792785645},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6272279024124146},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5937594771385193},{"id":"https://openalex.org/C99194444","wikidata":"https://www.wikidata.org/wiki/Q14906367","display_name":"Thrombospondin 1","level":3,"score":0.549370288848877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5491955876350403},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5439602732658386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47851359844207764},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.47808384895324707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46619170904159546},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.438416987657547},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41833531856536865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3917621970176697},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34422168135643005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23542892932891846},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2145475447177887},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21341881155967712},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19322261214256287},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.14736732840538025},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.1215755045413971},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11724472045898438},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0746101438999176},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019700","descriptor_name":"Thrombospondin 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.2009.00631.x","doi":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2009.00631.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2850410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2850410","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:20233213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20233213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.2009.00631.x","doi":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.2009.00631.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.2009.00631.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4915224427","display_name":"Thrombospondin-1 Regulates Vascular Tone","funder_award_id":"K22CA128616","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1647337374.pdf","grobid_xml":"https://content.openalex.org/works/W1647337374.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W44848436","https://openalex.org/W127742586","https://openalex.org/W1502165328","https://openalex.org/W1509418264","https://openalex.org/W1529948332","https://openalex.org/W1596708099","https://openalex.org/W1973983795","https://openalex.org/W1980360989","https://openalex.org/W1996406153","https://openalex.org/W2000075945","https://openalex.org/W2003630942","https://openalex.org/W2003794997","https://openalex.org/W2008437077","https://openalex.org/W2008650426","https://openalex.org/W2010850700","https://openalex.org/W2023644971","https://openalex.org/W2024862570","https://openalex.org/W2027673613","https://openalex.org/W2028046930","https://openalex.org/W2036524028","https://openalex.org/W2037009561","https://openalex.org/W2040261887","https://openalex.org/W2042436980","https://openalex.org/W2046938785","https://openalex.org/W2051558008","https://openalex.org/W2053197617","https://openalex.org/W2054935021","https://openalex.org/W2059281609","https://openalex.org/W2073439809","https://openalex.org/W2073858857","https://openalex.org/W2076618504","https://openalex.org/W2081347741","https://openalex.org/W2086121837","https://openalex.org/W2087929503","https://openalex.org/W2095222063","https://openalex.org/W2097433480","https://openalex.org/W2099312302","https://openalex.org/W2109407919","https://openalex.org/W2116403540","https://openalex.org/W2124067042","https://openalex.org/W2126671869","https://openalex.org/W2143340640","https://openalex.org/W2153948972","https://openalex.org/W2154480952","https://openalex.org/W2167352445","https://openalex.org/W2175642831","https://openalex.org/W2290277615"],"related_works":["https://openalex.org/W1988664338","https://openalex.org/W2036237867","https://openalex.org/W2012228368","https://openalex.org/W3173692569","https://openalex.org/W1825691755","https://openalex.org/W2015101923","https://openalex.org/W2060100462","https://openalex.org/W434792086","https://openalex.org/W2076618504","https://openalex.org/W2118188147"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,190],"PURPOSE:":[2],"Soluble":[3],"guanylate":[4],"cyclase":[5],"(sGC)":[6],"is":[7,197,244],"the":[8,16,41,101,141,164,177,213,226],"signal":[9],"transduction":[10],"enzyme":[11],"most":[12],"responsible":[13],"for":[14],"mediating":[15],"effects":[17],"of":[18,27,55,103,123,131,145,166,179,201,229],"nitric":[19],"oxide":[20],"(NO).":[21],"Recently,":[22],"NO-independent":[23,79],"small":[24,82],"molecule":[25],"activators":[26,106,125],"sGC":[28,56,76,80,105,124,151,180,234],"have":[29,33,38],"been":[30],"developed":[31],"that":[32,40,70,195,225,232],"promising":[34],"clinical":[35],"activities.":[36],"We":[37],"shown":[39],"secreted":[42],"matrix":[43],"protein":[44],"thrombospondin-1":[45],"(TSP-1)":[46],"binds":[47],"to":[48,169,183],"CD47":[49,74],"and":[50,59,65,90,110,116,129,143,158,206,222],"potently":[51],"inhibits":[52,75],"NO":[53],"stimulation":[54],"in":[57,100,134,140,154,156,187,216,238],"endothelial":[58],"vascular":[60],"smooth":[61,87],"muscle":[62,88],"cells":[63,89],"(VSMCs)":[64],"platelets.":[66,159],"Here":[67],"we":[68],"show":[69],"TSP-1":[71,97,160,174,196,217],"signalling":[72,243],"via":[73],"activation":[77],"by":[78],"activating":[81,181],"molecules.":[83],"EXPERIMENTAL":[84],"APPROACH:":[85],"Vascular":[86],"washed":[91],"human":[92],"platelets":[93],"were":[94,119],"pretreated":[95],"with":[96,212,218],"(2.2":[98],"nM)":[99],"presence":[102,142],"haeme-dependent":[104,205],"(YC-1,":[107],"BAY":[108],"41-2272),":[109],"a":[111,198],"haeme-independent":[112,207],"activator":[113],"(meso-porphyrin":[114],"IX),":[115],"cGMP":[117,155],"levels":[118],"measured.":[120],"The":[121],"effect":[122],"on":[126],"platelet":[127,172],"aggregation":[128],"contraction":[130,186],"VSMC":[132,157,185],"embedded":[133],"collagen":[135],"gels":[136],"was":[137],"also":[138,162],"assayed":[139],"absence":[144],"TSP-1.":[146],"KEY":[147],"RESULTS:":[148],"Thrombospondin-1":[149],"inhibited":[150,163],"activator-dependent":[152],"increase":[153],"pretreatment":[161,175],"ability":[165,178],"these":[167],"agents":[168,182],"delay":[170],"thrombin-induced":[171],"aggregation.":[173],"reduced":[176],"abrogate":[184],"vitro.":[188],"CONCLUSIONS":[189],"IMPLICATIONS:":[191],"This":[192],"work":[193],"demonstrates":[194],"universal":[199],"inhibitor":[200],"sGC,":[202],"blocking":[203],"both":[204],"activation.":[208],"These":[209],"data":[210],"coupled":[211],"reported":[214],"increases":[215],"age,":[219],"diabetes,":[220],"ischaemia/reperfusion,":[221],"atherosclerosis":[223],"implies":[224],"therapeutic":[227],"potential":[228],"all":[230],"drugs":[231],"activate":[233],"could":[235],"be":[236],"compromised":[237],"disease":[239],"states":[240],"where":[241],"TSP-1/CD47":[242],"elevated.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
