{"id":"https://openalex.org/W1646256271","doi":"https://doi.org/10.4049/jimmunol.180.6.4022","title":"Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection","display_name":"Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W1646256271","doi":"https://doi.org/10.4049/jimmunol.180.6.4022","mag":"1646256271","pmid":"https://pubmed.ncbi.nlm.nih.gov/18322211"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.180.6.4022","doi":"https://doi.org/10.4049/jimmunol.180.6.4022","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.180.6.4022","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/180/6/4022/983173/zim00608004022.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/180/6/4022/983173/zim00608004022.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012163897","display_name":"Silvia Bozza","orcid":"https://orcid.org/0000-0002-8163-2936","observed_orcids":["https://orcid.org/0000-0002-8163-2936"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Bozza","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058411762","display_name":"Teresa Zelante","orcid":"https://orcid.org/0000-0002-7071-0302","observed_orcids":["https://orcid.org/0000-0002-7071-0302"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teresa Zelante","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009727581","display_name":"Silvia Moretti","orcid":"https://orcid.org/0000-0002-8177-7254","observed_orcids":["https://orcid.org/0000-0002-8177-7254"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Moretti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041343367","display_name":"Pierluigi Bonifazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierluigi Bonifazi","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Antonella DeLuca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella DeLuca","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carmen D\u2019Angelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen D\u2019Angelo","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gloria Giovannini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gloria Giovannini","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040551472","display_name":"Cec\u00edlia Garlanda","orcid":"https://orcid.org/0000-0002-1510-7703","observed_orcids":["https://orcid.org/0000-0002-1510-7703"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Garlanda","raw_affiliation_strings":["Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan , Milan ,","\u2020Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan, Milan, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan , Milan ,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210153126","https://openalex.org/I4210163047"]},{"raw_affiliation_string":"\u2020Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan, Milan, Italy; and","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025153030","display_name":"Louis Boon","orcid":"https://orcid.org/0000-0002-0937-9171","observed_orcids":["https://orcid.org/0000-0002-0937-9171"]},"institutions":[{"id":"https://openalex.org/I4210108500","display_name":"Polpharma Biologics (Netherlands)","ror":"https://ror.org/02h8kp866","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210108500"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Louis Boon","raw_affiliation_strings":["Bioceros , Utrecht ,","\u2021Bioceros, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioceros , Utrecht ,","institution_ids":["https://openalex.org/I4210108500"]},{"raw_affiliation_string":"\u2021Bioceros, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210108500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105836024","display_name":"Francesco Bistoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Bistoni","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079557352","display_name":"Paolo Puccetti","orcid":"https://orcid.org/0000-0001-6674-2128","observed_orcids":["https://orcid.org/0000-0001-6674-2128"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Puccetti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048654641","display_name":"Alberto Mantovani","orcid":"https://orcid.org/0000-0001-5578-236X","observed_orcids":["https://orcid.org/0000-0001-5578-236X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Mantovani","raw_affiliation_strings":["Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan , Milan ,","\u2020Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan, Milan, Italy; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan , Milan ,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210153126","https://openalex.org/I4210163047"]},{"raw_affiliation_string":"\u2020Clinical Institute Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy, and Institute of General Pathology, University of Milan, Milan, Italy; and","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087834518","display_name":"Luigina R. Romani","orcid":"https://orcid.org/0000-0002-1356-525X","observed_orcids":["https://orcid.org/0000-0002-1356-525X"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigina Romani","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T. , Perugia ,","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"*Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, and Fondazione \u201cIstituto di Ricovero e Cura per le Biotecnologie Trapiantologiche\u201d I.B.i.T., Perugia, Italy;","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.962,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.9764399,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"180","issue":"6","first_page":"4022","last_page":"4031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":1.0},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7889999747276306},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/host-resistance","display_name":"host resistance","score":0.6179999709129333},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2778025104","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll","level":2,"score":0.721275806427002},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6635584235191345},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.43158113956451416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3990674614906311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32228225469589233},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30899909138679504},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.1582045555114746}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008172","descriptor_name":"Lung Diseases, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008172","descriptor_name":"Lung Diseases, Fungal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.180.6.4022","doi":"https://doi.org/10.4049/jimmunol.180.6.4022","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.180.6.4022","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/180/6/4022/983173/zim00608004022.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:18322211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18322211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.180.6.4022","doi":"https://doi.org/10.4049/jimmunol.180.6.4022","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.180.6.4022","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/180/6/4022/983173/zim00608004022.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1646256271.pdf","grobid_xml":"https://content.openalex.org/works/W1646256271.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1482128986","https://openalex.org/W1496750702","https://openalex.org/W1502749381","https://openalex.org/W1515994079","https://openalex.org/W1519886765","https://openalex.org/W1942463334","https://openalex.org/W1942899011","https://openalex.org/W1959096743","https://openalex.org/W1964465182","https://openalex.org/W1970434640","https://openalex.org/W1970659009","https://openalex.org/W1977179270","https://openalex.org/W1978231462","https://openalex.org/W1995744610","https://openalex.org/W2000581651","https://openalex.org/W2001717792","https://openalex.org/W2008045357","https://openalex.org/W2010453472","https://openalex.org/W2012680181","https://openalex.org/W2022022413","https://openalex.org/W2022406313","https://openalex.org/W2036767516","https://openalex.org/W2038312972","https://openalex.org/W2043765645","https://openalex.org/W2044854941","https://openalex.org/W2046779553","https://openalex.org/W2060527543","https://openalex.org/W2087058049","https://openalex.org/W2094786750","https://openalex.org/W2103272567","https://openalex.org/W2106201919","https://openalex.org/W2112133235","https://openalex.org/W2112613634","https://openalex.org/W2112866067","https://openalex.org/W2114180142","https://openalex.org/W2117047064","https://openalex.org/W2117771953","https://openalex.org/W2122262578","https://openalex.org/W2122939321","https://openalex.org/W2129077500","https://openalex.org/W2130941282","https://openalex.org/W2134632062","https://openalex.org/W2134770979","https://openalex.org/W2136926115","https://openalex.org/W2138107401","https://openalex.org/W2141576574","https://openalex.org/W2144129715","https://openalex.org/W2148421703","https://openalex.org/W2157310133","https://openalex.org/W2159722730","https://openalex.org/W2161426250"],"related_works":["https://openalex.org/W2044897537","https://openalex.org/W1519886765","https://openalex.org/W7096859903","https://openalex.org/W2094786750","https://openalex.org/W2066035954","https://openalex.org/W1538506784","https://openalex.org/W2231006224","https://openalex.org/W2095753163","https://openalex.org/W2137173669","https://openalex.org/W2510333491"],"abstract_inverted_index":{"TLRs":[0],"contribute":[1,160],"to":[2,19,75,85,96,142,149],"the":[3,16,33,45,97,100,163],"inflammatory":[4,69,118,155],"response":[5,18],"in":[6,59,89,107,115,129,170],"fungal":[7,26,60,143],"infections.":[8,61],"Although":[9],"inflammation":[10],"is":[11,137],"an":[12],"essential":[13],"component":[14],"of":[15,44,53,99,123,154],"protective":[17,166],"fungi,":[20],"its":[21],"dysregulation":[22],"may":[23,159],"significantly":[24],"worsen":[25],"diseases.":[27],"In":[28],"this":[29],"study,":[30],"we":[31],"tested":[32],"hypothesis":[34],"that":[35,116,135,146],"Toll":[36],"IL-1R8":[37],"(TIR8)/single":[38],"Ig":[39],"IL-1-related":[40],"receptor,":[41],"a":[42,50],"member":[43],"IL-1R":[46,103],"family":[47],"acting":[48],"as":[49],"negative":[51],"regulator":[52],"TLR/IL-1R":[54],"signaling,":[55],"affects":[56],"TLR":[57],"responses":[58,74],"Genetically":[62],"engineered":[63],"Tir8(-/-)":[64,90],"mice":[65,91],"were":[66,87,93,127],"assessed":[67],"for":[68,139],"and":[70,78,83,92,113,120,145,168],"adaptive":[71],"Th":[72],"cell":[73,109,125],"Candida":[76],"albicans":[77],"Aspergillus":[79],"fumigatus.":[80],"Inflammatory":[81],"pathology":[82,119],"susceptibility":[84],"infection":[86],"higher":[88],"causally":[94],"linked":[95],"activation":[98,110,126,153],"Th17":[101,108,124,156],"pathway.":[102],"signaling":[104],"was":[105],"involved":[106],"by":[111],"IL-6":[112],"TGF-beta":[114],"limited":[117],"relative":[121],"absence":[122],"observed":[128],"IL-1RI(-/-)":[130],"mice.":[131],"These":[132],"data":[133],"demonstrate":[134],"TIR8":[136,158],"required":[138],"host":[140],"resistance":[141],"infections":[144],"it":[147],"functions":[148],"negatively":[150],"regulate":[151],"IL-1-dependent":[152],"responses.":[157],"toward":[161],"fine-tuning":[162],"balance":[164],"between":[165],"immunity":[167],"immunopathology":[169],"infection.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}