{"id":"https://openalex.org/W1645763","doi":null,"title":"Mirtazapine versus selective serotonin reuptake inhibitors.","display_name":"Mirtazapine versus selective serotonin reuptake inhibitors.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1645763","mag":"1645763","pmid":"https://pubmed.ncbi.nlm.nih.gov/10446737"},"language":"en","primary_location":{"id":"pmid:10446737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101433219","display_name":"Christopher Thompson","orcid":"https://orcid.org/0000-0001-7447-408X","observed_orcids":["https://orcid.org/0000-0001-7447-408X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C Thompson","raw_affiliation_strings":["Department of Psychiatry, Royal South Hampshire Hospital, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Royal South Hampshire Hospital, Southampton, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101433219"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1536,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91752922,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"60 Suppl 17","issue":null,"first_page":"18","last_page":"22; discussion 46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13118","display_name":"Psychological Treatments and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mirtazapine","display_name":"mirtazapine","score":1.0},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":1.0},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":1.0},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.8140000104904175},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hamilton-depression-rating-scale","display_name":"Hamilton Depression Rating Scale","score":0.7649999856948853},{"id":"https://openalex.org/keywords/montgomery-asberg-depression-rating-scale","display_name":"Montgomery-Asberg Depression Rating Scale","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hamilton-anxiety-rating-scale","display_name":"Hamilton Anxiety Rating Scale","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2781068410","wikidata":"https://www.wikidata.org/wiki/Q421930","display_name":"Mirtazapine","level":4,"score":0.9085991382598877},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8416808843612671},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.77463698387146},{"id":"https://openalex.org/C2777490545","wikidata":"https://www.wikidata.org/wiki/Q409672","display_name":"Citalopram","level":4,"score":0.7530341148376465},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.627193808555603},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6085606813430786},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5102665424346924},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4893900752067566},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4457568824291229},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.4307257831096649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4262572228908539},{"id":"https://openalex.org/C2776466505","wikidata":"https://www.wikidata.org/wiki/Q385555","display_name":"Hamilton Rating Scale for Depression","level":4,"score":0.4145127534866333},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3973068296909332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32402878999710083},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.2906980514526367},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.17323914170265198},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.15334945917129517},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078785","descriptor_name":"Mirtazapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008803","descriptor_name":"Mianserin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017374","descriptor_name":"Paroxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10446737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Comparative Study"},{"id":"mag:1645763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051517388","https://openalex.org/W1567908185","https://openalex.org/W2059502896","https://openalex.org/W2229094993","https://openalex.org/W2075245372","https://openalex.org/W2028123499","https://openalex.org/W2350783263","https://openalex.org/W2375707730","https://openalex.org/W2168271065","https://openalex.org/W2379099725"],"abstract_inverted_index":{"The":[0,21,226],"results":[1,227],"of":[2,7,32,119,149,151,187,200,228,241],"3":[3,109],"completed":[4],"comparative":[5,41,78],"studies":[6,22,230],"mirtazapine":[8,120,167,216,233],"versus":[9],"selective":[10],"serotonin":[11],"reuptake":[12],"inhibitors":[13],"(SSRIs;":[14],"fluoxetine,":[15,44],"paroxetine,":[16,83,130],"and":[17,27,34,58,70,82,99,113,129,162,217],"citalopram)":[18],"are":[19],"reviewed.":[20],"aimed":[23],"to":[24,204,237],"compare":[25],"efficacy":[26,135,150],"tolerability":[28],"in":[29,117,133,139,196,212,221],"acute":[30],"treatment":[31,140],"inpatients":[33],"outpatients":[35],"with":[36,43,80,244],"major":[37],"depressive":[38],"disorder.":[39],"In":[40,76,107,165],"trials":[42,79],"patients":[45],"who":[46],"had":[47],"high":[48],"baseline":[49,178],"total":[50,88],"17-item":[51,100,160],"Hamilton":[52,181],"Rating":[53,91,182],"Scale":[54,92,183],"for":[55,184],"Depression":[56,90],"(HAM-D)":[57],"depressed":[59],"mood":[60],"item":[61],"scores":[62],"were":[63,87,121,136,155,219],"included":[64],"(scores":[65],">":[66,71,95,103],"or":[67,72,96,104],"=":[68,73,97,105],"21":[69],"2,":[74],"respectively).":[75],"the":[77,84,131,159,180,208],"citalopram":[81,128],"inclusion":[85],"criteria":[86],"Montgomery-Asberg":[89],"(MADRS)":[93],"score":[94,102],"22":[98],"HAM-D":[101,161],"18.":[106],"all":[108,188],"studies,":[110],"statistically":[111],"significant":[112],"clinically":[114],"relevant":[115],"differences":[116,132,154,211],"favor":[118],"evident":[122],"on":[123,157,179],"several":[124],"outcome":[125],"variables.":[126],"Against":[127],"antidepressant":[134],"registered":[137],"early":[138,239],"but":[141],"not":[142],"later,":[143],"thus":[144],"suggesting":[145],"potentially":[146],"faster":[147],"onset":[148],"mirtazapine.":[152],"These":[153],"demonstrated":[156,168],"both":[158],"MADRS":[163],"scales.":[164],"addition,":[166],"an":[169,238],"accelerated":[170],"anxiolytic":[171],"effect":[172],"as":[173,194],"shown":[174],"by":[175],"changes":[176],"from":[177],"Anxiety.":[185],"Tolerability":[186],"studied":[189],"compounds":[190],"was":[191],"very":[192],"good,":[193],"reflected":[195,220],"a":[197],"low":[198],"percentage":[199],"premature":[201],"terminations":[202],"due":[203],"adverse":[205,223],"events.":[206],"On":[207],"other":[209],"hand,":[210],"pharmacologic":[213],"profiles":[214],"between":[215],"SSRIs":[218],"their":[222],"events":[224],"profiles.":[225],"these":[229],"confirm":[231],"that":[232],"displays":[234],"good":[235,245],"efficacy--leading":[236],"relief":[240],"symptoms--in":[242],"combination":[243],"tolerability.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
