{"id":"https://openalex.org/W1642374554","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","title":"Regional hepatic therapies: an important component in the management of colorectal cancer liver metastases.","display_name":"Regional hepatic therapies: an important component in the management of colorectal cancer liver metastases.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1642374554","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","mag":"1642374554","pmid":"https://pubmed.ncbi.nlm.nih.gov/24570923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2914341","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054772551","display_name":"Abdul Saied Calvino","orcid":"https://orcid.org/0000-0002-0996-2527","observed_orcids":["https://orcid.org/0000-0002-0996-2527"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Saied","raw_affiliation_strings":["Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040099847","display_name":"Steven C. Katz","orcid":"https://orcid.org/0000-0002-6030-9312","observed_orcids":["https://orcid.org/0000-0002-6030-9312"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C Katz","raw_affiliation_strings":["Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112759390","display_name":"N. Joseph Espat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Joseph Espat","raw_affiliation_strings":["Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Adele Decof Cancer Center, Roger Williams Medical Center, Providence, RI, Boston University School of Medicine, MA, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1336196053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0703,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76338095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"2","first_page":"97","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9819999933242798},{"id":"https://openalex.org/keywords/unresectable-liver-metastases","display_name":"unresectable liver metastases","score":0.871999979019165},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion-chemotherapy","display_name":"hepatic arterial infusion chemotherapy","score":0.718999981880188},{"id":"https://openalex.org/keywords/hepatic-artery-embolization","display_name":"hepatic artery embolization","score":0.6949999928474426},{"id":"https://openalex.org/keywords/systemic-chemotherapy","display_name":"systemic chemotherapy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9552531242370605},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6295034885406494},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.502615213394165},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4844803512096405},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.47858524322509766},{"id":"https://openalex.org/C3020284061","wikidata":"https://www.wikidata.org/wiki/Q5194613","display_name":"Curative treatment","level":3,"score":0.4561547338962555},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.44865792989730835},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44143596291542053},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41811442375183105},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4038923978805542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38635164499282837},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1382552981376648},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2914341","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3924659","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary Surg Nutr","raw_type":"Text"},{"id":"pmid:24570923","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24570923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary surgery and nutrition","raw_type":"Journal Article"},{"id":"mag:1642374554","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24570923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2914341","doi":"https://doi.org/10.3978/j.issn.2304-3881.2012.12.07","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330066","display_name":"Sirtex Medical","ror":"https://ror.org/05gt90n14"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W31513995","https://openalex.org/W119872925","https://openalex.org/W1585593526","https://openalex.org/W1961040537","https://openalex.org/W1963943534","https://openalex.org/W1965842207","https://openalex.org/W1968439009","https://openalex.org/W1968690354","https://openalex.org/W1971647170","https://openalex.org/W1982577778","https://openalex.org/W1983975249","https://openalex.org/W1985524610","https://openalex.org/W1994069598","https://openalex.org/W2000180049","https://openalex.org/W2007345685","https://openalex.org/W2010047598","https://openalex.org/W2014996730","https://openalex.org/W2018433986","https://openalex.org/W2019068717","https://openalex.org/W2022338038","https://openalex.org/W2027613559","https://openalex.org/W2034904702","https://openalex.org/W2035454562","https://openalex.org/W2035779983","https://openalex.org/W2036073319","https://openalex.org/W2036672856","https://openalex.org/W2039463465","https://openalex.org/W2042223776","https://openalex.org/W2045615651","https://openalex.org/W2056991614","https://openalex.org/W2057842358","https://openalex.org/W2058242433","https://openalex.org/W2059334131","https://openalex.org/W2064516382","https://openalex.org/W2065475260","https://openalex.org/W2069794794","https://openalex.org/W2079190855","https://openalex.org/W2079530087","https://openalex.org/W2080960152","https://openalex.org/W2084470612","https://openalex.org/W2085295387","https://openalex.org/W2087923534","https://openalex.org/W2088591216","https://openalex.org/W2088974189","https://openalex.org/W2092143175","https://openalex.org/W2094313851","https://openalex.org/W2095930306","https://openalex.org/W2104263669","https://openalex.org/W2106845199","https://openalex.org/W2108314923","https://openalex.org/W2128915202","https://openalex.org/W2131239494","https://openalex.org/W2131740088","https://openalex.org/W2131835105","https://openalex.org/W2135423900","https://openalex.org/W2137900825","https://openalex.org/W2138235363","https://openalex.org/W2139336946","https://openalex.org/W2153868090","https://openalex.org/W2155854000","https://openalex.org/W2157265626","https://openalex.org/W2157416388","https://openalex.org/W2157813866","https://openalex.org/W2158500499","https://openalex.org/W2161470595","https://openalex.org/W2167676775","https://openalex.org/W2170281599","https://openalex.org/W2316178638","https://openalex.org/W2323751510","https://openalex.org/W2423096169"],"related_works":["https://openalex.org/W2222549087","https://openalex.org/W4211076372","https://openalex.org/W2214741795","https://openalex.org/W2036605261","https://openalex.org/W2756485777","https://openalex.org/W4411230763","https://openalex.org/W7125690575","https://openalex.org/W4281798152","https://openalex.org/W3049460291","https://openalex.org/W7161288995"],"abstract_inverted_index":{"The":[0,84],"treatment":[1,47,121],"of":[2,29,55,62,77,82,89],"colorectal":[3],"cancer":[4],"liver":[5],"metastases":[6],"(CRLM)":[7],"has":[8],"evolved":[9],"significantly":[10],"in":[11],"the":[12,21,45,53,104,117],"last":[13],"15":[14],"years.":[15],"Currently,":[16],"complete":[17,37],"surgical":[18],"resection":[19],"remains":[20],"only":[22],"potentially":[23],"curative":[24],"option;":[25],"unfortunately,":[26],"approximately":[27],"80%":[28],"patients":[30,41],"with":[31,42],"CRLM":[32,44,110],"are":[33,111],"not":[34],"candidates":[35],"for":[36,79,109,119],"tumor":[38],"resection.":[39],"For":[40],"unresectable":[43],"available":[46,106],"options":[48,70,118],"were":[49],"historically":[50],"limited;":[51],"however,":[52],"development":[54],"regional":[56],"hepatic":[57],"therapies":[58],"(RHT)":[59],"and":[60,75,87,98],"improvement":[61],"systemic":[63],"chemotherapeutic":[64],"regimens":[65],"have":[66],"emerged":[67],"as":[68,113],"viable":[69],"to":[71,116],"improve":[72],"overall":[73],"survival":[74],"quality":[76],"life":[78],"this":[80,102],"group":[81],"patients.":[83],"selection,":[85],"sequence":[86],"integration":[88],"interventions":[90],"into":[91],"a":[92,96,114],"multi-modal":[93],"approach":[94],"is":[95],"complex":[97],"evolving":[99],"discipline.":[100],"In":[101],"article,":[103],"currently":[105],"RHT":[107],"modalities":[108],"presented":[112],"guide":[115],"clinical":[120],"decisions.":[122]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
