{"id":"https://openalex.org/W1642295343","doi":"https://doi.org/10.21236/ada424040","title":"The Role of Capase-8 in Breast Carcinoma Cells","display_name":"The Role of Capase-8 in Breast Carcinoma Cells","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W1642295343","doi":"https://doi.org/10.21236/ada424040","mag":"1642295343"},"language":"en","primary_location":{"id":"doi:10.21236/ada424040","doi":"https://doi.org/10.21236/ada424040","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada424040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078834428","display_name":"Bryan C. Barnhart","orcid":"https://orcid.org/0000-0002-5640-1677","observed_orcids":["https://orcid.org/0000-0002-5640-1677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan C. Barnhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056606410","display_name":"Marcus E. Peter","orcid":"https://orcid.org/0000-0003-3216-036X","observed_orcids":["https://orcid.org/0000-0003-3216-036X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus E. Peter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.7929999828338623},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.8650000095367432},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/death-inducing-signaling-complex","display_name":"death-inducing signaling complex","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7879999876022339},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-cell-motility","display_name":"tumor cell motility","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.5759036540985107},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.543363094329834},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.49813055992126465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4088415801525116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38502076268196106},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34640783071517944},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2767319679260254},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12895366549491882}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21236/ada424040","doi":"https://doi.org/10.21236/ada424040","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada424040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA424040","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA424040","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058563436","https://openalex.org/W1978587144","https://openalex.org/W2025559703","https://openalex.org/W2040852036","https://openalex.org/W2032250159","https://openalex.org/W2329448329","https://openalex.org/W2084363870","https://openalex.org/W2071509119","https://openalex.org/W3004330647","https://openalex.org/W1991707369"],"abstract_inverted_index":{"CD95":[0,16,33,75,156],"mediated":[1,17,34],"apoptosis":[2,35,79],"is":[3,57,72,158],"important":[4],"for":[5],"numerous":[6,87,146],"processes,":[7],"and":[8,38,53,66,101,104,110,132,140,149],"often":[9],"tumor":[10,81,174],"cells":[11,82],"develop":[12],"a":[13,23,26],"resistance":[14],"to":[15,85,116,142],"apoptosis.":[18],"NCF7-Fas-Bcl-xl":[19],"cells,":[20,170],"which":[21,155,171],"are":[22,30,138],"model":[24],"of":[25,50,60,68,94,122,145,165,183],"breast":[27,147,168],"carcinoma":[28,169],"cell,":[29],"protected":[31],"from":[32],"by":[36],"binding":[37,52,64],"inactivating":[39],"active":[40],"caspase-8":[41,134,166],"generated":[42],"at":[43],"the":[44,58,61,69,92,120,123,129,143,152,163,181,184],"DISC":[45],"on":[46,119],"mitochondria.":[47],"The":[48,63],"mechanism":[49,67],"this":[51],"its":[54],"functional":[55],"relevance":[56],"subject":[59],"study.":[62],"properties":[65],"subsequent":[70],"degradation":[71],"addressed.":[73],"Additionally,":[74],"signaling":[76,88,157],"in":[77,91,108,154,167,176],"these":[78],"resistant":[80],"was":[83,114],"determined":[84,115],"activate":[86],"pathways,":[89],"resulting":[90],"activation":[93,121],"multiple":[95],"genes":[96],"including":[97],"anti-apoptotic,":[98],"pro-":[99],"proliferative,":[100],"pro-tumorigenic":[102],"genes,":[103],"ultimately":[105],"an":[106],"increase":[107,113],"motility":[109],"invasiveness.":[111],"This":[112],"be":[117],"dependent":[118],"NF-KB":[124],"pathway,":[125,131],"as":[126,128],"well":[127],"Erkl/2":[130],"interestingly,":[133],"activity.":[135],"These":[136],"observations":[137],"profound":[139],"relevant":[141],"study":[144],"cancers,":[148],"my":[150],"redefine":[151],"way":[153],"viewed.":[159],"It":[160],"also":[161],"addresses":[162],"role":[164],"may":[172],"induce":[173],"progression":[175],"certain":[177],"circumstances":[178],"rather":[179],"than":[180],"death":[182],"cell.":[185]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}
