{"id":"https://openalex.org/W1642077366","doi":"https://doi.org/10.1002/glia.22770","title":"Interferon regulatory factor 7 participates in the M 1\u2010like microglial polarization switch","display_name":"Interferon regulatory factor 7 participates in the M 1\u2010like microglial polarization switch","publication_year":2014,"publication_date":"2014-11-24","ids":{"openalex":"https://openalex.org/W1642077366","doi":"https://doi.org/10.1002/glia.22770","mag":"1642077366","pmid":"https://pubmed.ncbi.nlm.nih.gov/25422089"},"language":"en","primary_location":{"id":"doi:10.1002/glia.22770","doi":"https://doi.org/10.1002/glia.22770","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22770","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://asahikawa-med.repo.nii.ac.jp/records/5490","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005226273","display_name":"Tatsuhide Tanaka","orcid":"https://orcid.org/0000-0002-3373-9093","observed_orcids":["https://orcid.org/0000-0002-3373-9093"]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tatsuhide Tanaka","raw_affiliation_strings":["Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Hokkaido, Japan","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Koichi Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Murakami","raw_affiliation_strings":["Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878894","display_name":"Yoshio Band\u00f4","orcid":"https://orcid.org/0000-0002-2466-5248","observed_orcids":["https://orcid.org/0000-0002-2466-5248"]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Bando","raw_affiliation_strings":["Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan","institution_ids":["https://openalex.org/I147809708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111801519","display_name":"Shigetaka Yoshida","orcid":"https://orcid.org/0009-0003-0019-5143","observed_orcids":["https://orcid.org/0009-0003-0019-5143"]},"institutions":[{"id":"https://openalex.org/I147809708","display_name":"Asahikawa Medical University","ror":"https://ror.org/025h9kw94","country_code":"JP","type":"education","lineage":["https://openalex.org/I147809708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigetaka Yoshida","raw_affiliation_strings":["Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Anatomy and Neuroscience Asahikawa Medical University Hokkaido Japan","institution_ids":["https://openalex.org/I147809708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005226273"],"corresponding_institution_ids":["https://openalex.org/I147809708"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":3.2489,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.91062484,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"63","issue":"4","first_page":"595","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf7","display_name":"IRF7","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.8600000143051147},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"phenotypic switching","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8920000195503235},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.847000002861023},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neurotrophic-factor-secretion","display_name":"neurotrophic factor secretion","score":0.7379999756813049},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.796999990940094},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/stat1-phosphorylation","display_name":"STAT1 phosphorylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/microglia-neuron-interaction","display_name":"microglia-neuron interaction","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9704467058181763},{"id":"https://openalex.org/C2776966659","wikidata":"https://www.wikidata.org/wiki/Q18028003","display_name":"IRF7","level":4,"score":0.7281055450439453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.704799234867096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5923594236373901},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5164926052093506},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5038475394248962},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34297823905944824},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33727556467056274},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3338952958583832},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.29760128259658813},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21901938319206238},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20595407485961914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06899896264076233}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050839","descriptor_name":"Interferon Regulatory Factor-7","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050839","descriptor_name":"Interferon Regulatory Factor-7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/glia.22770","doi":"https://doi.org/10.1002/glia.22770","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.22770","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:25422089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25422089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01468:0006143767","doi":null,"is_oa":true,"landing_page_url":"https://asahikawa-med.repo.nii.ac.jp/records/5490","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Glia","raw_type":"journal article"},{"id":"pmh:amcor:id/25422089","doi":null,"is_oa":false,"landing_page_url":"http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=25422089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401647","display_name":"Asahikawa Medical University Collection and Research (Asahikawa Medical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I147809708","host_organization_name":"Asahikawa Medical University","host_organization_lineage":["https://openalex.org/I147809708"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01468:0006143767","doi":null,"is_oa":true,"landing_page_url":"https://asahikawa-med.repo.nii.ac.jp/records/5490","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Glia","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4871769871","display_name":"Analysis of microglial polarization switching.","funder_award_id":"26830040","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1511127813","https://openalex.org/W1906918777","https://openalex.org/W1940795041","https://openalex.org/W1961550958","https://openalex.org/W1967369695","https://openalex.org/W1972296893","https://openalex.org/W1973619847","https://openalex.org/W1977213877","https://openalex.org/W1989435502","https://openalex.org/W1995299599","https://openalex.org/W2001653597","https://openalex.org/W2003674452","https://openalex.org/W2006517495","https://openalex.org/W2009170266","https://openalex.org/W2011678998","https://openalex.org/W2015412022","https://openalex.org/W2028090656","https://openalex.org/W2031170591","https://openalex.org/W2039183048","https://openalex.org/W2040239818","https://openalex.org/W2041363468","https://openalex.org/W2045262404","https://openalex.org/W2053313069","https://openalex.org/W2053646585","https://openalex.org/W2054472394","https://openalex.org/W2060908677","https://openalex.org/W2063082801","https://openalex.org/W2063995449","https://openalex.org/W2066680385","https://openalex.org/W2070855360","https://openalex.org/W2081014274","https://openalex.org/W2085667648","https://openalex.org/W2093705034","https://openalex.org/W2094427913","https://openalex.org/W2095444837","https://openalex.org/W2100128950","https://openalex.org/W2100904149","https://openalex.org/W2108756356","https://openalex.org/W2120247510","https://openalex.org/W2123640179","https://openalex.org/W2123877754","https://openalex.org/W2124836944","https://openalex.org/W2128215483","https://openalex.org/W2131409211","https://openalex.org/W2133536768","https://openalex.org/W2134729461","https://openalex.org/W2139778190","https://openalex.org/W2146543727","https://openalex.org/W2148898943","https://openalex.org/W2156821568","https://openalex.org/W2161456562","https://openalex.org/W2170706621","https://openalex.org/W2170959966","https://openalex.org/W2171520885"],"related_works":["https://openalex.org/W2979963107","https://openalex.org/W2095444837","https://openalex.org/W2242800549","https://openalex.org/W2057101628","https://openalex.org/W1768846296","https://openalex.org/W2949951331","https://openalex.org/W2000187060","https://openalex.org/W2087251303","https://openalex.org/W2153137812","https://openalex.org/W1427803231"],"abstract_inverted_index":{"Microglia":[0],"are":[1,47],"generally":[2],"considered":[3],"the":[4,8,33,42,63,99,153,171],"immune":[5],"cells":[6],"of":[7,36,71,98,102,145,166,173,180],"central":[9],"nervous":[10],"system.":[11],"Recent":[12],"studies":[13],"have":[14],"demonstrated":[15],"that":[16,44,65,143,185],"under":[17],"specific":[18],"polarization":[19,46,139,195],"conditions,":[20],"microglia":[21,40,60,109,118,125,159],"develop":[22],"into":[23],"two":[24],"different":[25],"phenotypes,":[26],"termed":[27],"M1-like":[28,56,93,108,131,156],"and":[29,38,41,57,61,162,177],"M2-like":[30,59,72,106,117,124,154],"microglia.":[31,107,132],"However,":[32],"phenotypic":[34,67],"characteristics":[35],"M1-like-":[37],"M2-like-polarized":[39],"mechanisms":[43,64],"regulate":[45,66],"largely":[48],"unknown.":[49],"In":[50],"this":[51],"study,":[52],"we":[53],"characterized":[54,112,120],"lipopolysaccharide-treated":[55],"IL-4-treated":[58],"investigated":[62],"switching.":[68,196],"The":[69],"addition":[70],"microglial":[73,94,194],"conditioned":[74],"medium":[75],"(CM)":[76],"to":[77,138,155],"primary":[78],"neurons":[79,90],"resulted":[80],"in":[81,84,136,158,160,163,193],"an":[82,190],"increase":[83],"neurite":[85],"length":[86],"when":[87],"compared":[88],"with":[89,92],"treated":[91],"CM,":[95],"possibly":[96],"because":[97],"enhanced":[100],"secretion":[101],"neurotrophic":[103],"factors":[104],"by":[105,113,121],"were":[110,119],"morphologically":[111],"larger":[114],"soma,":[115],"whereas":[116],"long":[122],"processes.":[123],"exhibited":[126],"greater":[127],"phagocytic":[128],"capacity":[129],"than":[130],"These":[133],"features":[134],"switched":[135],"response":[137],"cues.":[140],"We":[141],"found":[142],"expression":[144,172],"interferon":[146],"regulatory":[147],"factor":[148],"7":[149],"(IRF7)":[150],"increased":[151],"during":[152],"switch":[157],"vitro":[161],"vivo.":[164],"Knockdown":[165],"IRF7":[167,186],"using":[168],"siRNA":[169],"suppressed":[170],"M1":[174],"marker":[175],"mRNA":[176],"reduced":[178],"phosphorylation":[179],"STAT1.":[181],"Our":[182],"findings":[183],"suggest":[184],"signaling":[187],"may":[188],"play":[189],"important":[191],"role":[192]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}