{"id":"https://openalex.org/W1642015145","doi":"https://doi.org/10.1099/00221287-146-1-199","title":"Three pathways for trehalose biosynthesis in mycobacteria","display_name":"Three pathways for trehalose biosynthesis in mycobacteria","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1642015145","doi":"https://doi.org/10.1099/00221287-146-1-199","mag":"1642015145","pmid":"https://pubmed.ncbi.nlm.nih.gov/10658666"},"language":"en","primary_location":{"id":"doi:10.1099/00221287-146-1-199","doi":"https://doi.org/10.1099/00221287-146-1-199","is_oa":false,"landing_page_url":"https://doi.org/10.1099/00221287-146-1-199","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1642015145"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110227042","display_name":"Koen A. L. De Smet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Koen A. L. De Smet","raw_affiliation_strings":["Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062912673","display_name":"Anthony Weston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Weston","raw_affiliation_strings":["Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, UK2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, UK2","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111449941","display_name":"Ivor N. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ivor N. Brown","raw_affiliation_strings":["Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111577872","display_name":"Douglas B. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Douglas B. Young","raw_affiliation_strings":["Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048343643","display_name":"Brian D. Robertson","orcid":"https://orcid.org/0000-0001-5785-5307","observed_orcids":["https://orcid.org/0000-0001-5785-5307"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Brian D. Robertson","raw_affiliation_strings":["Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary\u2019s Campus, Norfolk Place, London W2 1PG, UK1","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048343643"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":3.451,"has_fulltext":false,"cited_by_count":266,"citation_normalized_percentile":{"value":0.92028917,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"146","issue":"1","first_page":"199","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trehalose-biosynthesis","display_name":"trehalose biosynthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycobacteria","display_name":"mycobacteria","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mycobacterium-bovis-bcg","display_name":"Mycobacterium bovis BCG","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":0.9940000176429749},{"id":"https://openalex.org/keywords/trehalose-metabolism","display_name":"trehalose metabolism","score":0.7229999899864197},{"id":"https://openalex.org/keywords/udp-glucose","display_name":"UDP-glucose","score":0.6290000081062317},{"id":"https://openalex.org/keywords/maltose","display_name":"maltose","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.821588397026062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7448281645774841},{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.7388516664505005},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.6374363899230957},{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.6206276416778564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5505245327949524},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5487695932388306},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.5446552038192749},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4926329255104065},{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.42326271533966064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38624221086502075},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.368198037147522},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.34738489985466003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18868079781532288},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.10187634825706482},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.09099584817886353},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.07034605741500854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008320","descriptor_name":"Maltose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014199","descriptor_name":"Trehalose","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/00221287-146-1-199","doi":"https://doi.org/10.1099/00221287-146-1-199","is_oa":false,"landing_page_url":"https://doi.org/10.1099/00221287-146-1-199","pdf_url":null,"source":{"id":"https://openalex.org/S196799759","display_name":"Microbiology","issn_l":"1350-0872","issn":["1350-0872","1465-2080"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"pmid:10658666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10658666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology (Reading, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W223852105","https://openalex.org/W1276010910","https://openalex.org/W1480999188","https://openalex.org/W1554039407","https://openalex.org/W1565401097","https://openalex.org/W1604441141","https://openalex.org/W1612160157","https://openalex.org/W1652704082","https://openalex.org/W1998207782","https://openalex.org/W2003953466","https://openalex.org/W2018778397","https://openalex.org/W2022256231","https://openalex.org/W2034749656","https://openalex.org/W2035651986","https://openalex.org/W2037760587","https://openalex.org/W2054924586","https://openalex.org/W2063842337","https://openalex.org/W2065355538","https://openalex.org/W2066041798","https://openalex.org/W2066209597","https://openalex.org/W2072711160","https://openalex.org/W2082042773","https://openalex.org/W2098356079","https://openalex.org/W2104868544","https://openalex.org/W2108630388","https://openalex.org/W2109715166","https://openalex.org/W2112475430","https://openalex.org/W2122121924","https://openalex.org/W2123524214","https://openalex.org/W2126040811","https://openalex.org/W2149956451","https://openalex.org/W2153615653","https://openalex.org/W2158023121","https://openalex.org/W2158735659","https://openalex.org/W2161811059","https://openalex.org/W2168623726","https://openalex.org/W2315232969","https://openalex.org/W2893843115"],"related_works":["https://openalex.org/W2023817396","https://openalex.org/W2095463723","https://openalex.org/W2058445507","https://openalex.org/W1969559443","https://openalex.org/W2763971955","https://openalex.org/W2012089496","https://openalex.org/W2557486921","https://openalex.org/W7053324294","https://openalex.org/W1504340072","https://openalex.org/W2988872647"],"abstract_inverted_index":{"Trehalose":[0],"is":[1,135],"present":[2],"as":[3,13],"a":[4,14,124],"free":[5],"disaccharide":[6],"in":[7,20,59,111,128,138,154],"the":[8,38,104],"cytoplasm":[9],"of":[10,16,31,103,123,143],"mycobacteria":[11,76],"and":[12,43,67,83,96,116],"component":[15],"cell-wall":[17],"glycolipids":[18],"implicated":[19],"tissue":[21],"damage":[22],"associated":[23],"with":[24,46],"mycobacterial":[25,65,155],"infection.":[26],"To":[27],"obtain":[28],"an":[29,151],"overview":[30],"trehalose":[32,54,79,149],"metabolism,":[33],"we":[34],"analysed":[35],"data":[36],"from":[37,52,71,80,88,97],"Mycobacterium":[39,114,118,129],"tuberculosis":[40],"genome":[41],"project":[42],"identified":[44],"ORFs":[45,73],"homology":[47],"to":[48,108],"genes":[49],"encoding":[50],"enzymes":[51,69],"three":[53],"biosynthesis":[55],"pathways":[56,105,146],"previously":[57],"characterized":[58],"other":[60],"bacteria.":[61],"Functional":[62],"assays":[63],"using":[64],"extracts":[66],"recombinant":[68],"derived":[70],"these":[72],"demonstrated":[74],"that":[75,132,148],"can":[77],"produce":[78],"glucose":[81,91],"6-phosphate":[82],"UDP-glucose":[84],"(the":[85,93,99],"OtsA-OtsB":[86],"pathway)":[87,95],"glycogen-like":[89],"alpha(1-->4)-linked":[90],"polymers":[92],"TreY-TreZ":[94],"maltose":[98],"TreS":[100],"pathway).":[101],"Each":[102],"was":[106],"found":[107],"be":[109],"active":[110],"both":[112],"rapid-growing":[113],"smegmatis":[115],"slow-growing":[117],"bovis":[119],"BCG.":[120],"The":[121,141],"presence":[122,142],"disrupted":[125],"treZ":[126],"gene":[127],"leprae":[130],"suggests":[131],"this":[133,139],"pathway":[134],"not":[136],"functional":[137],"organism.":[140],"multiple":[144],"biosynthetic":[145],"indicates":[147],"plays":[150],"important":[152],"role":[153],"physiology.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
