{"id":"https://openalex.org/W1641618604","doi":"https://doi.org/10.4049/jimmunol.181.6.3877","title":"Cytokine-Mediated Inhibition of Fibrillar Amyloid-\u03b2 Peptide Degradation by Human Mononuclear Phagocytes","display_name":"Cytokine-Mediated Inhibition of Fibrillar Amyloid-\u03b2 Peptide Degradation by Human Mononuclear Phagocytes","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W1641618604","doi":"https://doi.org/10.4049/jimmunol.181.6.3877","mag":"1641618604","pmid":"https://pubmed.ncbi.nlm.nih.gov/18768842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2603577"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.181.6.3877","doi":"https://doi.org/10.4049/jimmunol.181.6.3877","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.181.6.3877","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/181/6/3877/1265511/zim01808003877.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/181/6/3877/1265511/zim01808003877.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004238920","display_name":"Masaru Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaru Yamamoto","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center , Omaha, NE 68198-5880","Department of Pharmacology & Experimental Neuroscience, Center for Neurovirology & Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center , Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Pharmacology & Experimental Neuroscience, Center for Neurovirology & Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088328383","display_name":"Tomomi Kiyota","orcid":"https://orcid.org/0000-0002-0862-6441","observed_orcids":["https://orcid.org/0000-0002-0862-6441"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomomi Kiyota","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007227109","display_name":"Shannon M. Walsh","orcid":"https://orcid.org/0000-0001-9845-629X","observed_orcids":["https://orcid.org/0000-0001-9845-629X"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M Walsh","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035605254","display_name":"Jianuo Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianuo Liu","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088728393","display_name":"Jonathan Kipnis","orcid":"https://orcid.org/0000-0002-3714-517X","observed_orcids":["https://orcid.org/0000-0002-3714-517X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Kipnis","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008524903","display_name":"Tsuneya Ikezu","orcid":"https://orcid.org/0000-0002-3979-8596","observed_orcids":["https://orcid.org/0000-0002-3979-8596"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsuneya Ikezu","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.9997,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.90884763,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"181","issue":"6","first_page":"3877","last_page":"3886"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-degradation","display_name":"amyloid beta degradation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/fibrillar-amyloid-beta","display_name":"fibrillar amyloid-beta","score":0.9210000038146973},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.878000020980835},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7649999856948853},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.906000018119812},{"id":"https://openalex.org/keywords/insulin-degrading-enzyme","display_name":"insulin-degrading enzyme","score":0.7699999809265137},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.6340000033378601},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7275707125663757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5791431069374084},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4822712540626526},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44660359621047974},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.43905436992645264},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43803030252456665},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43759840726852417},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41878095269203186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3390965163707733},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3266642093658447},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32201671600341797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2598254680633545},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19593417644500732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.181.6.3877","doi":"https://doi.org/10.4049/jimmunol.181.6.3877","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.181.6.3877","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/181/6/3877/1265511/zim01808003877.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:18768842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18768842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2603577","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2603577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.181.6.3877","doi":"https://doi.org/10.4049/jimmunol.181.6.3877","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.181.6.3877","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/181/6/3877/1265511/zim01808003877.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G812179197","display_name":"Neural Immunity in HIV Dementia","funder_award_id":"P01NS043985","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320316613","display_name":"Nebraska Tobacco Settlement Biomedical Research Development Fund","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1641618604.pdf","grobid_xml":"https://content.openalex.org/works/W1641618604.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1535417449","https://openalex.org/W1545148544","https://openalex.org/W1586876258","https://openalex.org/W1621971853","https://openalex.org/W1693283493","https://openalex.org/W1964741226","https://openalex.org/W1966977299","https://openalex.org/W1968014528","https://openalex.org/W1975258429","https://openalex.org/W1987398071","https://openalex.org/W1991993391","https://openalex.org/W1996155848","https://openalex.org/W1996821202","https://openalex.org/W1998208719","https://openalex.org/W2001349268","https://openalex.org/W2004660702","https://openalex.org/W2009156994","https://openalex.org/W2009639401","https://openalex.org/W2010464023","https://openalex.org/W2011666658","https://openalex.org/W2026156322","https://openalex.org/W2028937444","https://openalex.org/W2030011352","https://openalex.org/W2032694200","https://openalex.org/W2036094153","https://openalex.org/W2050216330","https://openalex.org/W2051926625","https://openalex.org/W2057821000","https://openalex.org/W2062084653","https://openalex.org/W2069895863","https://openalex.org/W2082487815","https://openalex.org/W2091551200","https://openalex.org/W2101486467","https://openalex.org/W2112216133","https://openalex.org/W2147904592","https://openalex.org/W2156716608","https://openalex.org/W2170944561","https://openalex.org/W2419588077"],"related_works":["https://openalex.org/W1974966491","https://openalex.org/W78553266","https://openalex.org/W2897137341","https://openalex.org/W2018626218","https://openalex.org/W2098456470","https://openalex.org/W2010464023","https://openalex.org/W2062084653","https://openalex.org/W1511127813","https://openalex.org/W2011205127","https://openalex.org/W1995648866"],"abstract_inverted_index":{"Vaccination":[0],"therapy":[1],"of":[2,13,20,53,65,79,88,113,121,131,179,201,205,226],"AD":[3],"animal":[4],"models":[5],"and":[6,36,59,74,81,84,91,95,106,119,134,142,147,160,169,173,183,190,246],"patients":[7],"strongly":[8],"suggests":[9],"an":[10,110],"active":[11],"role":[12],"brain":[14],"mononuclear":[15],"phagocytes":[16],"in":[17,24,103,154,199,217,241],"immune-mediated":[18],"clearance":[19],"amyloid-beta":[21],"peptides":[22],"(Abeta)":[23],"brain.":[25],"Although":[26],"Abeta":[27,43,66,115,152,215,239],"uptake":[28,87,112],"by":[29,34,100,136,223],"macrophages":[30,72],"can":[31],"be":[32],"regulated":[33],"pro-":[35,58],"anti-inflammatory":[37,60,245],"cytokines,":[38],"their":[39],"effects":[40],"on":[41],"macrophage-mediated":[42],"degradation":[44,64,97,122,153,216,240],"are":[45,197],"poorly":[46],"understood.":[47],"To":[48],"better":[49],"understand":[50],"this":[51],"mechanism":[52],"degradation,":[54,138],"we":[55],"examined":[56],"whether":[57],"cytokines":[61,237,248],"affect":[62],"the":[63,128,177],"using":[67,76],"primary":[68],"cultured":[69],"human":[70],"monocyte-derived":[71],"(MDM)":[73],"microglia":[75],"pulse-chase":[77],"analysis":[78],"fibrillar":[80,89,132],"oligomer":[82],"(125)I-Abeta40":[83],"Abeta42.":[85],"Initial":[86],"Abeta40":[90,133],"Abeta42":[92,135],"was":[93,98,220],"40%":[94],"its":[96],"saturated":[99],"120":[101],"h":[102],"both":[104],"MDM":[105,155,206],"microglia,":[107],"compared":[108],"with":[109,207],"initial":[111],"oligomeric":[114],"less":[116],"than":[117],"0.5%":[118],"saturation":[120],"within":[123],"24":[124],"h.":[125],"IFN-gamma":[126,172],"increased":[127],"intracellular":[129],"retention":[130],"inhibiting":[137],"whereas":[139,243],"IL-4,":[140],"IL-10,":[141],"TGF-beta1,":[143],"but":[144,165,209],"not":[145,210],"IL-13":[146],"IL-27,":[148],"enhanced":[149],"degradation.":[150],"Fibrillar":[151],"is":[156],"sensitive":[157],"to":[158,167],"lysosomal":[159],"insulin":[161,180],"degrading":[162,181],"enzyme":[163,182],"inhibitors":[164],"insensitive":[166],"proteasomal":[168],"neprilysin":[170],"inhibitors.":[171],"TNF-alpha":[174],"directly":[175],"reduced":[176],"expression":[178],"chaperone":[184],"molecules":[185],"(heat":[186],"shock":[187,192],"protein":[188,194],"70":[189],"heat":[191],"cognate":[193],"70),":[195],"which":[196,219],"involved":[198],"refolding":[200],"aggregated":[202],"proteins.":[203],"Coculture":[204],"activated,":[208],"naive":[211],"T":[212],"cells,":[213],"suppressed":[214],"MDM,":[218,242],"partially":[221],"blocked":[222],"a":[224],"combination":[225],"neutralizing":[227],"Abs":[228],"against":[229],"proinflammatory":[230,236],"cytokines.":[231],"These":[232],"data":[233],"suggest":[234],"that":[235],"suppress":[238],"select":[244],"regulatory":[247],"antagonize":[249],"these":[250],"effects.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
