{"id":"https://openalex.org/W1640275698","doi":"https://doi.org/10.1126/science.1163475","title":"Neuron Research Leaps Ahead","display_name":"Neuron Research Leaps Ahead","publication_year":2008,"publication_date":"2008-08-29","ids":{"openalex":"https://openalex.org/W1640275698","doi":"https://doi.org/10.1126/science.1163475","mag":"1640275698","pmid":"https://pubmed.ncbi.nlm.nih.gov/18755965"},"language":"en","primary_location":{"id":"doi:10.1126/science.1163475","doi":"https://doi.org/10.1126/science.1163475","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1163475","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025571618","display_name":"Robert H. Brown","orcid":"https://orcid.org/0000-0001-6062-1528","observed_orcids":["https://orcid.org/0000-0001-6062-1528"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert H. Brown","raw_affiliation_strings":["Massachusetts General Hospital, 16th Street, Navy Yard, Charlestown, MA 02129, USA","Massachusetts General Hospital, 16th Street, Navy Yard, Charlestown, MA 02129, USA. E-mail: rhbrown@partners.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, 16th Street, Navy Yard, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital, 16th Street, Navy Yard, Charlestown, MA 02129, USA. E-mail: rhbrown@partners.org","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025571618"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.1127,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.43065171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"321","issue":"5893","first_page":"1169","last_page":"1170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/stem-cell-reprogramming","display_name":"stem cell reprogramming","score":0.7419999837875366},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.890999972820282},{"id":"https://openalex.org/keywords/in-vitro-disease-model","display_name":"in vitro disease model","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fibroblast-reprogramming","display_name":"fibroblast reprogramming","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C2777705401","wikidata":"https://www.wikidata.org/wiki/Q6457570","display_name":"LEAPS","level":2,"score":0.9847991466522217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5056014060974121},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4612411856651306},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4522276222705841},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.14359593391418457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1004118025302887},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072105","descriptor_name":"Superoxide Dismutase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1163475","doi":"https://doi.org/10.1126/science.1163475","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1163475","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:18755965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18755965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1978173381","https://openalex.org/W2002179012","https://openalex.org/W2013606687","https://openalex.org/W2018110972","https://openalex.org/W2079870118","https://openalex.org/W2103612759","https://openalex.org/W2125987139","https://openalex.org/W2128815118","https://openalex.org/W2130271153","https://openalex.org/W2135107819","https://openalex.org/W2136681577","https://openalex.org/W2138977668","https://openalex.org/W2142046859"],"related_works":["https://openalex.org/W3150416287","https://openalex.org/W7082039226","https://openalex.org/W1965910001","https://openalex.org/W2101631778","https://openalex.org/W2005996699","https://openalex.org/W4205856357","https://openalex.org/W7098354690","https://openalex.org/W2050204715","https://openalex.org/W2098069311","https://openalex.org/W1885301965"],"abstract_inverted_index":{"There":[0],"has":[1,35],"been":[2,36],"substantial":[3],"progress":[4],"in":[5,46,69,78,89],"defining":[6],"the":[7,43,52,56,63,70,123],"primary":[8],"molecular":[9],"defects":[10],"causing":[11],"inherited":[12],"forms":[13],"of":[14,45,55,65,72],"major":[15],"neurodegenerative":[16],"diseases":[17,34],"such":[18],"as":[19],"Alzheimer's":[20],"disease,":[21],"amyotrophic":[22],"lateral":[23],"sclerosis":[24],"(ALS),":[25],"and":[26,58,113],"Parkinson's":[27],"disease.":[28],"However,":[29],"developing":[30],"therapies":[31],"for":[32],"these":[33,73,95],"hindered":[37],"by":[38,97],"several":[39],"experimental":[40],"limitations,":[41],"including":[42],"absence":[44],"vitro":[47],"models":[48],"that":[49,86,105],"accurately":[50],"reproduce":[51],"genetic":[53],"milieu":[54],"disease":[57],"inadequate":[59],"systems":[60],"to":[61,127],"dissect":[62],"roles":[64],"diverse":[66,128],"cell":[67,91],"types":[68],"pathogenesis":[71],"diseases.":[74,130],"On":[75],"page":[76],"1218":[77],"this":[79],"issue,":[80],"Dimos":[81],"et":[82],"al.":[83],"(1)":[84],"demonstrate":[85],"new":[87],"technologies":[88],"stem":[90,103],"biology":[92],"may":[93],"overcome":[94],"barriers":[96],"reprogramming":[98],"adult":[99],"fibroblasts":[100],"into":[101],"embryonic":[102],"cells":[104,111],"can":[106],"subsequently":[107],"yield":[108],"patient-specific":[109],"neural":[110],"(neurons":[112],"astroglial":[114],"cells)":[115],"(1).":[116],"The":[117],"study":[118],"focuses":[119],"on":[120],"ALS,":[121],"but":[122],"findings":[124],"are":[125],"applicable":[126],"neurological":[129]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
