{"id":"https://openalex.org/W163712909","doi":null,"title":"Preclinical evaluation of Sm-153-DOTMP as a therapeutic bone-seeking radiopharmaceutical","display_name":"Preclinical evaluation of Sm-153-DOTMP as a therapeutic bone-seeking radiopharmaceutical","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W163712909","mag":"163712909"},"language":"en","primary_location":{"id":"mag:163712909","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1751","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108574012","display_name":"Jaime Sim\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime Sim\u00f3n","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108675199","display_name":"R. Keith Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Keith Frank","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044406696","display_name":"Druce K. Crump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Druce K. Crump","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065942241","display_name":"Jason A. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Rogers","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shannon Phillips","orcid":"https://orcid.org/0000-0001-5697-9156","observed_orcids":["https://orcid.org/0000-0001-5697-9156"]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Phillips","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":"https://orcid.org/0000-0001-5697-9156","affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084978032","display_name":"Scot Ellebracht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094817","display_name":"IsoTherapeutics Group (United States)","ror":"https://ror.org/00hz0qn68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094817"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scot Ellebracht","raw_affiliation_strings":["IsoTherapeutics Group LLC, Angleton, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IsoTherapeutics Group LLC, Angleton, TX","institution_ids":["https://openalex.org/I4210094817"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088814426","display_name":"Naoto Tada Ueno","orcid":"https://orcid.org/0000-0002-0166-7275","observed_orcids":["https://orcid.org/0000-0002-0166-7275"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoto T. Ueno","raw_affiliation_strings":["UT\u2010M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":"https://orcid.org/0000-0002-0166-7275","affiliations":[{"raw_affiliation_string":"UT\u2010M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111688451","display_name":"Richard E. Wendt","orcid":"https://orcid.org/0000-0001-6215-4206","observed_orcids":["https://orcid.org/0000-0001-6215-4206"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Wendt","raw_affiliation_strings":["UT\u2010M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT\u2010M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.01757382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"52","issue":null,"first_page":"1751","last_page":"1751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/samarium-153","display_name":"samarium-153","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bone-seeking-radiopharmaceuticals","display_name":"bone-seeking radiopharmaceuticals","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8370000123977661},{"id":"https://openalex.org/keywords/saturation-effects","display_name":"saturation effects","score":0.621999979019165},{"id":"https://openalex.org/keywords/high-dose-radiotherapy","display_name":"high-dose radiotherapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.7887201905250549},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5963119268417358},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5958402752876282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5719650983810425},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5199753046035767},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5091659426689148},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4897959232330322},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.48136717081069946},{"id":"https://openalex.org/C149857219","wikidata":"https://www.wikidata.org/wiki/Q5239054","display_name":"Effective dose (radiation)","level":2,"score":0.43295520544052124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34124308824539185},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3364311158657074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3054041266441345},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2762506604194641},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24168825149536133},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13490664958953857},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:163712909","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/52/supplement_1/1751","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022765064","https://openalex.org/W2348439401","https://openalex.org/W2272155453","https://openalex.org/W1898092403","https://openalex.org/W1154177420","https://openalex.org/W1809261514","https://openalex.org/W2994100353","https://openalex.org/W193279618","https://openalex.org/W1805060424","https://openalex.org/W2162292616"],"abstract_inverted_index":{"1751":[0],"Objectives":[2],"High-dose":[4],"bone-seeking":[5],"radiopharmaceuticals":[6],"have":[7,25],"been":[8],"investigated":[9],"for":[10,66,70,131,214,258,271],"treating":[11],"conditions":[12],"such":[13],"as":[14,199],"breast":[15],"cancer":[16],"bone":[17],"metastasis":[18],"or":[19,114],"multiple":[20],"myeloma.":[21],"Bartlett":[22],"et":[23],"al.":[24],"reported":[26],"a":[27,62,67,93,120,126,243,272],"saturation":[28,68,206,244],"effect":[29,69,245],"within":[30],"the":[31,132,205,208,211,217,221],"range":[32],"of":[33,37,50,82,100,103,123,128,177,184,187,210,216,220,267],"desirable":[34],"administered":[35,90,117,181,223,254],"activities":[36],"high-dose":[38,71],"Sm-153-EDTMP.":[39],"Sm-153-DOTMP":[40,72,91,239,268],"(1,":[41],"4,":[42,141],"7,":[43],"10-tetraazacyclododecanetetramethylenephosphonic":[44],"acid)":[45],"is":[46,269],"theoretically":[47],"superior":[48],"because":[49],"its":[51,75],"more":[52],"favorable":[53,270],"chelant-to-metal":[54,121],"ratio":[55,122],"(1.5:1":[56],"vs.":[57,226],"273:1).":[58],"This":[59],"study":[60],"in":[61,125,147],"rat":[63],"model":[64],"looked":[65],"and":[73,105,144,168,172,193,197,265],"assessed":[74],"biodistribution.":[76],"Methods":[78],"Five":[80],"cohorts":[81,134,176],"seven":[83,178],"Sprague-Dawley":[84],"rats,":[85],"weighing":[86],"275\u00b111.1":[87],"g,":[88],"were":[89,152,170,180],"using":[92],"tail":[94],"vein":[95],"injection.":[96],"The":[97,150,263],"dosage":[98,227],"consisted":[99],"100":[101,129],"uCi":[102],"Sm-153":[104],"sufficient":[106],"Sm-152":[107],"to":[108,139,249,255],"simulate":[109],"8,":[110],"16,":[111],"24,":[112,192],"32,":[113],"40":[115,185],"mCi":[116,186],"activity":[118,224],"at":[119,190,246],"1.5:1":[124],"volume":[127],"uL":[130],"five":[133],"respectively.":[135],"These":[136],"dosages":[137,183,247],"correspond":[138],"2,":[140,191],"6,":[142],"8":[143],"10":[145],"Ci":[146],"human":[148,256],"beings.":[149],"animals":[151],"sacrificed":[153,189],"3.09\u00b10.11":[154],"hours":[155,195],"after":[156],"administration.":[157],"Blood,":[158],"heart,":[159],"lung,":[160],"liver,":[161],"spleen,":[162],"kidney,":[163],"muscle,":[164],"stomach,":[165],"intestines,":[166],"femur":[167],"excreta":[169],"collected":[171],"assayed.":[173],"Then,":[174],"three":[175],"rats":[179],"simulated":[182],"Sm-153-DOTMP,":[188],"48":[194],"respectively,":[196],"processed":[198],"above.":[200],"Results":[202],"In":[204],"study,":[207],"slope":[209],"linear":[212],"regression":[213],"each":[215],"sampled":[218],"tissues":[219],"percentage":[222],"(%ID)":[225],"was":[228],"not":[229,241],"significantly":[230],"different":[231],"from":[232],"zero":[233],"(p":[234],"Conclusions":[237],"does":[240],"exhibit":[242],"equivalent":[248],"those":[250],"that":[251],"would":[252],"be":[253],"beings":[257],"therapy":[259],"with":[260],"curative":[261],"intent.":[262],"biodistribution":[264],"clearance":[266],"bone-seeking,":[273],"therapeutic":[274],"radiopharmaceutical.":[275],"Research":[277],"Support":[278],"NCI":[280],"R43CA150601":[281]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
