{"id":"https://openalex.org/W1634540901","doi":null,"title":"The effect of full length and mature NAG-1 protein overexpression on cytotoxicity of celecoxib, tamoxifen and doxorubicin in HT1080.","display_name":"The effect of full length and mature NAG-1 protein overexpression on cytotoxicity of celecoxib, tamoxifen and doxorubicin in HT1080.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1634540901","mag":"1634540901","pmid":"https://pubmed.ncbi.nlm.nih.gov/22615612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3304365"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3304365","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Daru","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004585579","display_name":"Saba Barezi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S Barezi","raw_affiliation_strings":["Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology-Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040654724","display_name":"Najmeh Fahham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Fahham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027867925","display_name":"Mohammad Seyedabadi","orcid":"https://orcid.org/0000-0003-0044-8270","observed_orcids":["https://orcid.org/0000-0003-0044-8270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Seyedabadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047836568","display_name":"Seyed Nasser Ostad","orcid":"https://orcid.org/0000-0002-5476-8010","observed_orcids":["https://orcid.org/0000-0002-5476-8010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Ostad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103392102","display_name":"Mohammad Hosein Ghahremani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Ghahremani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"3","first_page":"163","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nag-1","display_name":"NAG-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.6830000281333923},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.996999979019165},{"id":"https://openalex.org/keywords/ht1080-cells","display_name":"HT1080 cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777751087","wikidata":"https://www.wikidata.org/wiki/Q5636047","display_name":"HT1080","level":3,"score":0.913662314414978},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6680459976196289},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5678530931472778},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5564256906509399},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5341668725013733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5248753428459167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4768967628479004},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4571109414100647},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.45335474610328674},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45243245363235474},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4355371594429016},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3904949128627777},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38424021005630493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3810157775878906},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.32931989431381226},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26883476972579956},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2173042595386505},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18536412715911865},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16920268535614014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11570215225219727},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.07459554076194763},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.048524051904678345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3304365","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Daru","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2361066","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3304365","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22615612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22615612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5adcf639a8e74fdcb603a93bab5b0422","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5adcf639a8e74fdcb603a93bab5b0422","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DARU: Journal of Pharmaceutical Sciences, Vol 18, Iss 3, Pp 163-167 (2010)","raw_type":"article"},{"id":"mag:1634540901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22615612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3304365","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3304365/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Daru","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1634540901.pdf","grobid_xml":"https://content.openalex.org/works/W1634540901.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1973987061","https://openalex.org/W1977621160","https://openalex.org/W2001642234","https://openalex.org/W2020474446","https://openalex.org/W2021533617","https://openalex.org/W2031760644","https://openalex.org/W2036284522","https://openalex.org/W2044187991","https://openalex.org/W2053042661","https://openalex.org/W2054183406","https://openalex.org/W2061185707","https://openalex.org/W2082480079","https://openalex.org/W2090834124","https://openalex.org/W2102359623","https://openalex.org/W2109560931","https://openalex.org/W2117234919","https://openalex.org/W2158554664","https://openalex.org/W2162856680","https://openalex.org/W2164218519","https://openalex.org/W2169552095","https://openalex.org/W2169658646"],"related_works":["https://openalex.org/W3185935225","https://openalex.org/W2414089825","https://openalex.org/W2036284522","https://openalex.org/W2169552095","https://openalex.org/W2061185707","https://openalex.org/W2005588966","https://openalex.org/W7025621202","https://openalex.org/W1569470217","https://openalex.org/W2054082864","https://openalex.org/W2338655541"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"THE":[2,5],"PURPOSE":[3],"OF":[4],"STUDY:":[6],"Non-steroidal":[7],"anti-inflammatory":[8],"drug-activated":[9],"gene-1":[10],"(NAG-1)":[11],"is":[12,27,40,294],"involved":[13],"in":[14,52,59,85,119,145,209,239,256,268,280,288],"inflammation,":[15],"apoptosis/survival":[16],"and":[17,32,44,76,96,105,110,117,131,142,158,160,180,196,215,227,241,254,270,284,303],"tumorigenesis":[18],"as":[19,21,29,34,296],"well":[20],"resistance":[22,250,279],"to":[23,218,251],"chemotherapy.":[24],"NAG-1":[25,39,48,58,80,100,124,133,173,198,208,236,246,263,274,281,293],"protein":[26],"synthesized":[28],"pro-peptide,":[30],"cleaved":[31],"secreted":[33],"mature":[35,77,97,132,197],"protein.":[36],"Regulation":[37],"of":[38,47,57,66,73,79,93,99,103,113,139,154,169,172,178,190,204,212,225,235,262,286],"not":[41,200],"completely":[42],"discovered":[43],"increased":[45],"level":[46],"has":[49],"been":[50],"reported":[51],"many":[53],"cancers.":[54],"The":[55,167,187,202,223],"expression":[56,247,264,275],"cancer":[60,301],"cells":[61,107,121,141,175,182,192,206,220,229,238,265,283],"could":[62],"affect":[63],"the":[64,71,91,111,210],"progression":[65],"tumor":[67,304],"growth.":[68],"In":[69,88,258],"addition":[70],"secretion":[72],"full":[74,94,194],"length":[75,95,130,195],"forms":[78,98],"can":[81,276],"influence":[82],"cell":[83],"proliferation":[84,177,224,267],"other":[86],"cells.":[87,147,272,291],"this":[89],"study":[90],"role":[92],"on":[101,176],"viability":[102,161,203,287],"HT-1080":[104],"MCF-7":[106,179,228,269],"were":[108,125,149,183,199,230],"evaluated,":[109],"cytotoxicity":[112],"celecoxib,":[114,156],"indomethacin,":[115,155,213],"tamoxifen":[116,157,216],"doxorubicin":[118,159,214,255],"HT1080":[120,146,181,191,205,226,271],"stably":[122,143],"expressing":[123,174,193,207,237,282,290],"also":[126,184],"tested.":[127,185],"METHODS:":[128],"Full":[129],"was":[134,162,221],"cloned":[135],"from":[136],"cDNA":[137],"library":[138],"HCT116":[140],"transfected":[144],"Cells":[148],"treated":[150],"with":[151],"different":[152],"concentrations":[153],"assessed":[163],"by":[164,232],"MTT":[165],"assay.":[166],"effect":[168],"conditioned":[170,233],"medium":[171,234,261],"RESULTS:":[186],"growth":[188],"curves":[189],"different.":[201],"presence":[211],"compared":[217],"untransfected":[219],"higher.":[222],"inhibited":[231],"24":[240],"48":[242],"hrs.":[243],"MAJOR":[244],"CONCLUSION:":[245],"enhances":[248],"drug":[249,278],"tamoxifen,":[252],"indomethacin":[253],"HT1080.":[257],"addition,":[259],"condition":[260],"inhibits":[266],"Thus,":[273,292],"induce":[277],"inhibition":[285],"non":[289],"suggested":[295],"a":[297],"marker":[298],"for":[299],"effective":[300],"chemotherapy":[302],"progression.":[305]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}