{"id":"https://openalex.org/W1634101700","doi":null,"title":"Role of Histamine in the Regulation of Human Eosinophil Apoptosis","display_name":"Role of Histamine in the Regulation of Human Eosinophil Apoptosis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1634101700","mag":"1634101700"},"language":"en","primary_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67671","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67671","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67671/1/951-44-6775-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://trepo.tuni.fi/bitstream/10024/67671/1/951-44-6775-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036670818","display_name":"Hannele Hasala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hannele Hasala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036670818"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/eosinophil-apoptosis","display_name":"eosinophil apoptosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8209999799728394},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8840000033378601},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6740000247955322},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.6039999723434448},{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.6980000138282776},{"id":"https://openalex.org/keywords/eosinophilic-asthma","display_name":"eosinophilic asthma","score":0.35100001096725464},{"id":"https://openalex.org/keywords/eosinophilic-rhinosinusitis","display_name":"eosinophilic rhinosinusitis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/eosinophilic-bronchitis","display_name":"eosinophilic bronchitis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/eosinophilic-esophagitis","display_name":"eosinophilic esophagitis","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7585042715072632},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6897198557853699},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.6804581880569458},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5088251233100891},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37694427371025085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34732627868652344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3241623044013977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18825268745422363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14643403887748718},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.12646484375}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:trepo.tuni.fi:10024/67671","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67671","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67671/1/951-44-6775-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"pmh:oai:tampub.uta.fi:10024/67671","doi":null,"is_oa":false,"landing_page_url":"http://tampub.uta.fi/handle/10024/67671","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},{"id":"mag:1634101700","doi":null,"is_oa":false,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67671","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:trepo.tuni.fi:10024/67671","doi":null,"is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/67671","pdf_url":"https://trepo.tuni.fi/bitstream/10024/67671/1/951-44-6775-2.pdf","source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=V\u00e4it\u00f6skirja | en=Doctoral dissertation|"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311806","display_name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/022wvrv65"},{"id":"https://openalex.org/F4320322592","display_name":"Tampereen Yliopisto","ror":"https://ror.org/033003e23"},{"id":"https://openalex.org/F4320324052","display_name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00yp3hb50"},{"id":"https://openalex.org/F4320325149","display_name":"Filha","ror":"https://ror.org/01m9jhr72"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1634101700.pdf","grobid_xml":"https://content.openalex.org/works/W1634101700.grobid-xml"},"referenced_works_count":204,"referenced_works":["https://openalex.org/W41010650","https://openalex.org/W156887710","https://openalex.org/W178946232","https://openalex.org/W219992786","https://openalex.org/W1484315431","https://openalex.org/W1506955202","https://openalex.org/W1529680890","https://openalex.org/W1578051247","https://openalex.org/W1582824952","https://openalex.org/W1605170243","https://openalex.org/W1628031477","https://openalex.org/W1794581424","https://openalex.org/W1847746464","https://openalex.org/W1896311455","https://openalex.org/W1930515007","https://openalex.org/W1935322656","https://openalex.org/W1953047110","https://openalex.org/W1966043711","https://openalex.org/W1966159794","https://openalex.org/W1967224057","https://openalex.org/W1968295892","https://openalex.org/W1968692366","https://openalex.org/W1969109740","https://openalex.org/W1969594061","https://openalex.org/W1970648068","https://openalex.org/W1972355061","https://openalex.org/W1972833715","https://openalex.org/W1974058875","https://openalex.org/W1978098394","https://openalex.org/W1978689032","https://openalex.org/W1979129905","https://openalex.org/W1979378314","https://openalex.org/W1980066697","https://openalex.org/W1980996212","https://openalex.org/W1982256662","https://openalex.org/W1982287477","https://openalex.org/W1983962580","https://openalex.org/W1984113136","https://openalex.org/W1984214199","https://openalex.org/W1984417766","https://openalex.org/W1985411605","https://openalex.org/W1986257767","https://openalex.org/W1989212984","https://openalex.org/W1989697230","https://openalex.org/W1989913574","https://openalex.org/W1990195184","https://openalex.org/W1994101665","https://openalex.org/W1994256610","https://openalex.org/W1995593745","https://openalex.org/W1995605852","https://openalex.org/W1996587485","https://openalex.org/W1999838741","https://openalex.org/W2000476522","https://openalex.org/W2001464122","https://openalex.org/W2001588895","https://openalex.org/W2002372722","https://openalex.org/W2003387372","https://openalex.org/W2003655725","https://openalex.org/W2006512957","https://openalex.org/W2006758118","https://openalex.org/W2006950815","https://openalex.org/W2011128900","https://openalex.org/W2011292298","https://openalex.org/W2011353053","https://openalex.org/W2011382880","https://openalex.org/W2012087980","https://openalex.org/W2013125458","https://openalex.org/W2013255276","https://openalex.org/W2013349676","https://openalex.org/W2013361230","https://openalex.org/W2013396311","https://openalex.org/W2013573744","https://openalex.org/W2014943803","https://openalex.org/W2017543645","https://openalex.org/W2017760925","https://openalex.org/W2020614682","https://openalex.org/W2024052734","https://openalex.org/W2024395135","https://openalex.org/W2024904064","https://openalex.org/W2026694052","https://openalex.org/W2027042060","https://openalex.org/W2031906032","https://openalex.org/W2032382363","https://openalex.org/W2032393468","https://openalex.org/W2033362656","https://openalex.org/W2033711751","https://openalex.org/W2034350096","https://openalex.org/W2034844750","https://openalex.org/W2034915619","https://openalex.org/W2036706758","https://openalex.org/W2036866060","https://openalex.org/W2036963336","https://openalex.org/W2038547454","https://openalex.org/W2041102059","https://openalex.org/W2041718345","https://openalex.org/W2042985675","https://openalex.org/W2043382313","https://openalex.org/W2043391766","https://openalex.org/W2044076804","https://openalex.org/W2044696938","https://openalex.org/W2045106554","https://openalex.org/W2046848104","https://openalex.org/W2048589504","https://openalex.org/W2049024233","https://openalex.org/W2051916700","https://openalex.org/W2052677994","https://openalex.org/W2054537722","https://openalex.org/W2054824421","https://openalex.org/W2055203083","https://openalex.org/W2056324134","https://openalex.org/W2057239437","https://openalex.org/W2058644368","https://openalex.org/W2059985102","https://openalex.org/W2059995799","https://openalex.org/W2061049725","https://openalex.org/W2061278890","https://openalex.org/W2061497413","https://openalex.org/W2062399840","https://openalex.org/W2063155750","https://openalex.org/W2063630313","https://openalex.org/W2065338281","https://openalex.org/W2066107385","https://openalex.org/W2067541649","https://openalex.org/W2069400651","https://openalex.org/W2070973166","https://openalex.org/W2071206933","https://openalex.org/W2073174532","https://openalex.org/W2074371965","https://openalex.org/W2076485183","https://openalex.org/W2078601060","https://openalex.org/W2079587906","https://openalex.org/W2081776165","https://openalex.org/W2082293109","https://openalex.org/W2082755088","https://openalex.org/W2082782319","https://openalex.org/W2083425324","https://openalex.org/W2084859214","https://openalex.org/W2085577426","https://openalex.org/W2087025056","https://openalex.org/W2087509980","https://openalex.org/W2087807334","https://openalex.org/W2090254346","https://openalex.org/W2091213060","https://openalex.org/W2091408032","https://openalex.org/W2091686229","https://openalex.org/W2092601318","https://openalex.org/W2094155854","https://openalex.org/W2097901958","https://openalex.org/W2101035994","https://openalex.org/W2101086655","https://openalex.org/W2102985419","https://openalex.org/W2106777744","https://openalex.org/W2112175677","https://openalex.org/W2116932347","https://openalex.org/W2121464855","https://openalex.org/W2121651456","https://openalex.org/W2124657042","https://openalex.org/W2130191484","https://openalex.org/W2133895139","https://openalex.org/W2134285032","https://openalex.org/W2136790250","https://openalex.org/W2140068522","https://openalex.org/W2140773676","https://openalex.org/W2140942460","https://openalex.org/W2141144196","https://openalex.org/W2142047593","https://openalex.org/W2144266634","https://openalex.org/W2145354141","https://openalex.org/W2147651285","https://openalex.org/W2147654380","https://openalex.org/W2148396162","https://openalex.org/W2153232658","https://openalex.org/W2154405537","https://openalex.org/W2155345300","https://openalex.org/W2158251899","https://openalex.org/W2158528246","https://openalex.org/W2158969445","https://openalex.org/W2165373478","https://openalex.org/W2165556354","https://openalex.org/W2166312785","https://openalex.org/W2167216302","https://openalex.org/W2167900561","https://openalex.org/W2168691139","https://openalex.org/W2168841009","https://openalex.org/W2170413821","https://openalex.org/W2171418244","https://openalex.org/W2262618850","https://openalex.org/W2266029732","https://openalex.org/W2282042267","https://openalex.org/W2291620044","https://openalex.org/W2292202903","https://openalex.org/W2394992044","https://openalex.org/W2399210400","https://openalex.org/W2404573200","https://openalex.org/W2411440617","https://openalex.org/W2414964888","https://openalex.org/W2417329099","https://openalex.org/W2423106512","https://openalex.org/W2464651370","https://openalex.org/W3147588112","https://openalex.org/W3217178944","https://openalex.org/W4312320457","https://openalex.org/W4313343401","https://openalex.org/W4406065813"],"related_works":["https://openalex.org/W2067541649","https://openalex.org/W2017760925","https://openalex.org/W161107723","https://openalex.org/W7132455880","https://openalex.org/W2082782319","https://openalex.org/W2132874616","https://openalex.org/W1987445668","https://openalex.org/W2460448533","https://openalex.org/W7095246936","https://openalex.org/W2289849490"],"abstract_inverted_index":{"Eosinofiilinen":[0],"tulehdus":[1,39],"on":[2,16],"t\u00e4rke\u00e4":[3],"tekij\u00e4":[4],"astman":[5],"ja":[6,38,46,136],"allergisten":[7,23],"sairauksien":[8,24],"synnyss\u00e4.":[9],"My\u00f6s":[10],"tulehdussoluista":[11],"allergeenialtistuksen":[12],"j\u00e4lkeen":[13,61],"vapautuva":[14],"histamiini":[15,128],"olennainen":[17],"allergiaoireiden":[18],"kehittymisess\u00e4.":[19],"Antihistamiineja":[20],"k\u00e4ytet\u00e4\u00e4nkin":[21],"yleisesti":[22],"hoidossa.":[25,187],"Apoptoosia":[26],"eli":[27],"ohjelmoitua":[28],"solukuolemaa":[29],"pidet\u00e4\u00e4n":[30],"keskeisen\u00e4":[31],"mekanismina,":[32],"jonka":[33,60,92],"avulla":[34],"tulehdussoluja":[35],"poistuu":[36],"kudoksista":[37],"lievittyy.":[40],"Hannele":[41],"Hasalan":[42],"v\u00e4it\u00f6skirjatutkimuksessa":[43],"arvioitiin":[44,63],"histamiinin":[45,139],"antihistamiinien":[47,183],"merkityst\u00e4":[48],"eosinofiilisten":[49],"valkosolujen":[50],"apoptoosin":[51],"s\u00e4\u00e4telyss\u00e4.":[52],"Vapaaehtoisten":[53],"henkil\u00f6iden":[54],"verest\u00e4":[55],"eristettyj\u00e4":[56],"eosinofiilej\u00e4":[57,71],"viljeltiin":[58],"koeolosuhteissa,":[59],"apoptoosia":[62,79,132,142],"eri":[64],"menetelmill\u00e4.\\n\\nHistamiinin":[65],"havaittiin":[66],"osittain":[67],"kumoavan":[68],"interleukiini-5-sytokiinin":[69],"(IL-5:n)":[70],"hengiss\u00e4pit\u00e4v\u00e4\u00e4":[72],"vaikutusta":[73],"tehostamalla":[74],"eosinofiilien":[75,78,131,141,150,175],"apoptoosia.":[76],"Histamiinin":[77,102],"lis\u00e4\u00e4v\u00e4":[80],"vaikutus":[81,103,160],"oli":[82],"vastaavaa":[83],"suuruusluokkaa":[84],"kuin":[85],"aiemmin":[86],"havaittu":[87],"glukokortikoidien":[88,96],"aiheuttama":[89],"eosinofiiliapoptoosin":[90,164],"tehostuminen,":[91],"ajatellaan":[93],"olevan":[94],"yksi":[95,181],"t\u00e4rkeimmist\u00e4":[97],"eosinofiilist\u00e4":[98],"tulehdusta":[99,158],"lievitt\u00e4vist\u00e4":[100],"ominaisuuksista.":[101],"ei":[104],"n\u00e4ytt\u00e4nyt":[105],"v\u00e4littyv\u00e4n":[106],"mink\u00e4\u00e4n":[107],"tunnetun":[108],"histamiinireseptorin":[109,172],"eik\u00e4":[110],"muiden":[111],"amiinireseptorien":[112],"ep\u00e4spesifisen":[113],"aktivaation":[114],"kautta,":[115],"mik\u00e4":[116],"viittaa":[117],"siihen,":[118],"ett\u00e4":[119],"eosinofiileiss\u00e4":[120],"saattaa":[121,129,167,178],"ilmenty\u00e4":[122],"uusi,":[123],"toistaiseksi":[124,170],"tuntematon":[125],"histamiinireseptori.":[126],"Vaihtoehtoisesti":[127],"tehostaa":[130],"ei-reseptoriv\u00e4litteisesti.":[133],"Antihistamiinit":[134],"difenhydramiini":[135],"kloorifeniramiini":[137],"lis\u00e4siv\u00e4t":[138],"tavoin":[140],"IL-5:n":[143],"l\u00e4sn\u00e4ollessa,":[144],"kun":[145],"taas":[146],"ketotifeeni":[147],"sai":[148],"aikaan":[149],"nekroottisen":[151],"solu-kuoleman.\\n\\nTulosten":[152],"mukaan":[153],"histamiinilla":[154],"voi":[155],"olla":[156,180],"my\u00f6s":[157,179],"hillitsev\u00e4":[159],"allergiassa":[161],"sen":[162],"tehostaman":[163],"takia.":[165],"T\u00e4m\u00e4":[166],"v\u00e4litty\u00e4":[168],"uuden,":[169],"tuntemattoman":[171],"kautta.":[173],"Suora":[174],"solukuoleman":[176],"s\u00e4\u00e4tely":[177],"joidenkin":[182],"terapeuttisista":[184],"vaikutuksista":[185],"allergian":[186]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}