{"id":"https://openalex.org/W163314026","doi":"https://doi.org/10.1016/j.ccm.2013.09.005","title":"Oral Therapies for Pulmonary Arterial Hypertension","display_name":"Oral Therapies for Pulmonary Arterial Hypertension","publication_year":2013,"publication_date":"2013-11-21","ids":{"openalex":"https://openalex.org/W163314026","doi":"https://doi.org/10.1016/j.ccm.2013.09.005","mag":"163314026","pmid":"https://pubmed.ncbi.nlm.nih.gov/24267306"},"language":"en","primary_location":{"id":"doi:10.1016/j.ccm.2013.09.005","doi":"https://doi.org/10.1016/j.ccm.2013.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ccm.2013.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S42926609","display_name":"Clinics in Chest Medicine","issn_l":"0272-5231","issn":["0272-5231","1557-8216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics in Chest Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068539599","display_name":"Richard N. Channick","orcid":"https://orcid.org/0000-0002-9016-4468","observed_orcids":["https://orcid.org/0000-0002-9016-4468"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Channick","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: rchannick@partners.org","Division of Pulmonary and Critical Care Medicine; Massachusetts General Hospital; Harvard Medical School; Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: rchannick@partners.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine; Massachusetts General Hospital; Harvard Medical School; Boston MA USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iona Preston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iona Preston","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, New England Medical Center, Tufts University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, New England Medical Center, Tufts University, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071223454","display_name":"James R. Klinger","orcid":"https://orcid.org/0000-0003-2997-5955","observed_orcids":["https://orcid.org/0000-0003-2997-5955"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Klinger","raw_affiliation_strings":["Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068539599"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":null,"fwci":0.208,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.20769231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"4","first_page":"811","last_page":"824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-therapy","display_name":"oral therapy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pulmonary-vasodilators","display_name":"pulmonary vasodilators","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/drug-mechanisms","display_name":"drug mechanisms","score":0.5899999737739563},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/drug-limitations","display_name":"drug limitations","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9404174089431763},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6081579923629761},{"id":"https://openalex.org/C3017990168","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Orally active","level":3,"score":0.5874242782592773},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4763396084308624},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.45424920320510864},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.43403956294059753},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4272111654281616},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32405972480773926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3170117139816284},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.2821708917617798},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14301756024360657}],"mesh":[{"descriptor_ui":"D000068581","descriptor_name":"Tadalafil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068677","descriptor_name":"Sildenafil Citrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058986","descriptor_name":"Phosphodiesterase 5 Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065627","descriptor_name":"Familial Primary Pulmonary Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ccm.2013.09.005","doi":"https://doi.org/10.1016/j.ccm.2013.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ccm.2013.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S42926609","display_name":"Clinics in Chest Medicine","issn_l":"0272-5231","issn":["0272-5231","1557-8216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics in Chest Medicine","raw_type":"journal-article"},{"id":"pmid:24267306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24267306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinics in chest medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W103139616","https://openalex.org/W161240884","https://openalex.org/W1540498597","https://openalex.org/W1802716503","https://openalex.org/W1931029783","https://openalex.org/W1963720544","https://openalex.org/W1964184415","https://openalex.org/W1966835781","https://openalex.org/W1968302061","https://openalex.org/W1968709722","https://openalex.org/W1972208840","https://openalex.org/W1974227996","https://openalex.org/W1980429840","https://openalex.org/W1980762198","https://openalex.org/W1989435406","https://openalex.org/W1989792368","https://openalex.org/W1989984634","https://openalex.org/W1991255552","https://openalex.org/W1997011290","https://openalex.org/W1998543688","https://openalex.org/W2001314044","https://openalex.org/W2001706988","https://openalex.org/W2004177921","https://openalex.org/W2013930857","https://openalex.org/W2021965311","https://openalex.org/W2024527509","https://openalex.org/W2028930776","https://openalex.org/W2029370867","https://openalex.org/W2029592790","https://openalex.org/W2035736227","https://openalex.org/W2039467394","https://openalex.org/W2047399574","https://openalex.org/W2048443661","https://openalex.org/W2051069436","https://openalex.org/W2055710498","https://openalex.org/W2056055192","https://openalex.org/W2059341870","https://openalex.org/W2064652073","https://openalex.org/W2067313134","https://openalex.org/W2071350467","https://openalex.org/W2073590270","https://openalex.org/W2073884245","https://openalex.org/W2079063592","https://openalex.org/W2084858489","https://openalex.org/W2085220858","https://openalex.org/W2092237225","https://openalex.org/W2093620671","https://openalex.org/W2093881387","https://openalex.org/W2094151199","https://openalex.org/W2099246517","https://openalex.org/W2100283402","https://openalex.org/W2101386214","https://openalex.org/W2103058477","https://openalex.org/W2114079218","https://openalex.org/W2121376498","https://openalex.org/W2121538692","https://openalex.org/W2121688503","https://openalex.org/W2126534770","https://openalex.org/W2128435880","https://openalex.org/W2130400938","https://openalex.org/W2137267977","https://openalex.org/W2139041982","https://openalex.org/W2142303909","https://openalex.org/W2143132974","https://openalex.org/W2148038451","https://openalex.org/W2148200263","https://openalex.org/W2148663698","https://openalex.org/W2150989458","https://openalex.org/W2152540922","https://openalex.org/W2153625446","https://openalex.org/W2159214565","https://openalex.org/W2160314451","https://openalex.org/W2162804111","https://openalex.org/W2165378187","https://openalex.org/W2166811364","https://openalex.org/W2168113891","https://openalex.org/W2252374439","https://openalex.org/W2267563665","https://openalex.org/W2331798828","https://openalex.org/W2338761443","https://openalex.org/W2340048352","https://openalex.org/W2396142444","https://openalex.org/W2407424865","https://openalex.org/W2411426681","https://openalex.org/W2416661914","https://openalex.org/W6712042657","https://openalex.org/W6714061942"],"related_works":["https://openalex.org/W2774011618","https://openalex.org/W2359812130","https://openalex.org/W2076599539","https://openalex.org/W2183738246","https://openalex.org/W2000728653","https://openalex.org/W3146298770","https://openalex.org/W2030759015","https://openalex.org/W2082664121","https://openalex.org/W2038943891","https://openalex.org/W117397968"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}