{"id":"https://openalex.org/W1632995414","doi":"https://doi.org/10.1158/1538-7445.am2014-4426","title":"Abstract 4426: Tumor suppressive effects of wild-type Hras on oncogenic Kras-driven pancreatic tumorigenesis","display_name":"Abstract 4426: Tumor suppressive effects of wild-type Hras on oncogenic Kras-driven pancreatic tumorigenesis","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1632995414","doi":"https://doi.org/10.1158/1538-7445.am2014-4426","mag":"1632995414"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-4426","doi":"https://doi.org/10.1158/1538-7445.am2014-4426","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4426","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042976615","display_name":"Jamie D. Weyandt","orcid":"https://orcid.org/0000-0001-5602-5782","observed_orcids":["https://orcid.org/0000-0001-5602-5782"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie D. Weyandt","raw_affiliation_strings":["Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087099776","display_name":"Christopher M. Counter","orcid":"https://orcid.org/0000-0003-0748-3079","observed_orcids":["https://orcid.org/0000-0003-0748-3079"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Counter","raw_affiliation_strings":["Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"4426","last_page":"4426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.847000002861023},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6399999856948853},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.902999997138977},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7120000123977661},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-growth-arrest","display_name":"tumor growth arrest","score":0.5389999747276306},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.5049999952316284},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.9931119680404663},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9336695671081543},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7894289493560791},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7346240878105164},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7181262969970703},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6883663535118103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6099206209182739},{"id":"https://openalex.org/C2777362581","wikidata":"https://www.wikidata.org/wiki/Q10881532","display_name":"Molecular oncology","level":4,"score":0.4710514545440674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4548152685165405},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.433212548494339},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.4128459095954895},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.34698134660720825},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2200320065021515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19690868258476257},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.12434455752372742}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-4426","doi":"https://doi.org/10.1158/1538-7445.am2014-4426","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4426","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100174630","https://openalex.org/W2221319669","https://openalex.org/W2322625569","https://openalex.org/W2268032170","https://openalex.org/W7099680334","https://openalex.org/W1965084174","https://openalex.org/W7096869341","https://openalex.org/W4386293350","https://openalex.org/W2558255316","https://openalex.org/W2799708148"],"abstract_inverted_index":{"Abstract":[0],"The":[1,73],"RAS":[2,49,74,108,121,309],"proteins":[3,75,122,310],"are":[4,19,46,76],"a":[5,22,193,251],"group":[6],"of":[7,26,38,59,139,146,156,169,181,201,218,234,242,266,293,327,338,343],"small":[8],"GTPases":[9],"that":[10,18,95,119,133,259,281],"can":[11,249],"become":[12],"constitutively":[13],"activated":[14,137,240],"by":[15,262],"point":[16],"mutations":[17],"found":[20,132,258],"in":[21,31,34,104,125,176,196,224,231,306],"quarter":[23],"or":[24,199],"more":[25,313],"all":[27,77],"cancer":[28,149],"patients,":[29],"particularly":[30],"pancreatic":[32,148,162,182,213,226,333],"cancer,":[33,114,214],"which":[35,60,142],"over":[36],"90%":[37],"patients":[39],"have":[40,90],"an":[41,202,222],"activating":[42],"KRAS":[43],"mutation.":[44],"There":[45],"three":[47],"well-characterized":[48],"protein":[50],"family":[51],"members:":[52],"HRAS,":[53],"NRAS,":[54],"and":[55,71,83,101,211,228,245,257,274,295],"KRAS,":[56,141,244],"the":[57,65,154,170,197,232,269,290,339,344],"latter":[58],"is":[61,109,136,239,303],"alternatively":[62],"spliced":[63],"at":[64,80],"C-terminus":[66],"into":[67,192],"two":[68],"proteins,":[69],"KRAS4A":[70],"KRAS4B.":[72],"nearly":[78],"identical":[79],"their":[81],"N-termini":[82],"core":[84],"effector":[85],"binding":[86],"domains.":[87],"However,":[88,300],"they":[89],"divergent":[91],"C-terminal":[92],"membrane-binding":[93],"regions":[94],"impart":[96],"both":[97,264],"different":[98],"subcellular":[99],"localization":[100],"subtle":[102],"changes":[103],"signaling.":[105],"While":[106],"oncogenic":[107,140,177,243,247,285,331],"well":[110],"established":[111],"to":[112,208,221,289],"promote":[113,312],"recent":[115],"work":[116],"has":[117],"suggested":[118],"wild-type":[120,134,157,171,273,282,308,328],"also":[123],"participate":[124],"tumorigenesis.":[126,299,334],"In":[127],"this":[128],"regard,":[129],"we":[130,165,255],"previously":[131],"HRAS":[135,238],"downstream":[138,241],"promoted":[143],"tumor":[144,163],"growth":[145,253,291],"human":[147],"cell":[150],"lines.":[151],"To":[152],"examine":[153],"role":[155],"Hras":[158,172,185,219,276,283,329],"during":[159],"de":[160],"novo":[161],"development,":[164],"tested":[166,256],"whether":[167],"knockout":[168],"gene":[173],"altered":[174],"tumorigenesis":[175],"Kras-driven":[178,332],"mice":[179,188],"models":[180],"cancer.":[183],"Specifically,":[184],"homozygous":[186],"null":[187,275],"(Hras-/-)":[189],"were":[190],"crossed":[191],"Pdx-Cre;LSL-KRasG12D/+":[194],"background":[195],"absence":[198],"presence":[200],"additional":[203],"mutant":[204],"p53":[205],"allele":[206],"(Trp53R172H/+)":[207],"induce":[209,250],"early":[210,225,298],"late":[212,235],"respectively.":[215],"Surprisingly,":[216],"loss":[217],"led":[220],"increase":[223],"lesions":[227],"reduced":[229],"survival":[230,270],"model":[233],"disease.":[236],"Since":[237],"high":[246],"signaling":[248],"senescent":[252],"arrest,":[254],"suppressing":[260],"senescence":[261,294,302],"mutating":[263],"alleles":[265],"Trp53":[267],"ameliorated":[268],"difference":[271],"between":[272],"mice.":[277],"We":[278],"thus":[279],"hypothesize":[280],"amplifies":[284],"Kras":[286],"signaling,":[287],"leading":[288],"arrest":[292],"thereby":[296],"inhibit":[297],"once":[301],"suppressed":[304],"later":[305],"tumorigenesis,":[307],"instead":[311],"malignant":[314],"phenotypes.":[315],"Citation":[316],"Format:":[317],"Jamie":[318],"D.":[319],"Weyandt,":[320],"Christopher":[321],"M.":[322],"Counter.":[323],"Tumor":[324],"suppressive":[325],"effects":[326],"on":[330],"[abstract].":[335],"In:":[336],"Proceedings":[337],"105th":[340],"Annual":[341],"Meeting":[342],"American":[345],"Association":[346],"for":[347],"Cancer":[348,359],"Research;":[349],"2014":[350],"Apr":[351],"5-9;":[352],"San":[353],"Diego,":[354],"CA.":[355],"Philadelphia":[356],"(PA):":[357],"AACR;":[358],"Res":[360],"2014;74(19":[361],"Suppl):Abstract":[362],"nr":[363],"4426.":[364],"doi:10.1158/1538-7445.AM2014-4426":[365]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}