{"id":"https://openalex.org/W1632467620","doi":"https://doi.org/10.1371/journal.ppat.1005133","title":"Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways","display_name":"Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways","publication_year":2015,"publication_date":"2015-08-28","ids":{"openalex":"https://openalex.org/W1632467620","doi":"https://doi.org/10.1371/journal.ppat.1005133","mag":"1632467620","pmid":"https://pubmed.ncbi.nlm.nih.gov/26317337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552728"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1005133","doi":"https://doi.org/10.1371/journal.ppat.1005133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005133","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005133&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005133&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077445259","display_name":"Nora Grahl","orcid":"https://orcid.org/0000-0002-7227-9261","observed_orcids":["https://orcid.org/0000-0002-7227-9261"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora Grahl","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009010756","display_name":"Elora G. Demers","orcid":"https://orcid.org/0000-0002-1709-7430","observed_orcids":["https://orcid.org/0000-0002-1709-7430"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elora G. Demers","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070708675","display_name":"Allia K. Lindsay","orcid":"https://orcid.org/0000-0002-1508-8258","observed_orcids":["https://orcid.org/0000-0002-1508-8258"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allia K. Lindsay","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037962789","display_name":"Colleen E. Harty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen E. Harty","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016384352","display_name":"Sven D. Willger","orcid":"https://orcid.org/0000-0002-9736-2926","observed_orcids":["https://orcid.org/0000-0002-9736-2926"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven D. Willger","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023065200","display_name":"Amy E. Piispanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Piispanen","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013463468","display_name":"Deborah A. Hogan","orcid":"https://orcid.org/0000-0002-6366-2971","observed_orcids":["https://orcid.org/0000-0002-6366-2971"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deborah A. Hogan","raw_affiliation_strings":["Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013463468"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":4.7712,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96031004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"11","issue":"8","first_page":"e1005133","last_page":"e1005133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ras1","display_name":"Ras1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cyr1","display_name":"CYR1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ira2","display_name":"IRA2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mitochondrial-activity","display_name":"mitochondrial activity","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hyphal-growth","display_name":"hyphal growth","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mitochondrial-complex-iv","display_name":"mitochondrial complex IV","score":0.9139999747276306},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.7649999856948853},{"id":"https://openalex.org/keywords/amp-kinase","display_name":"AMP kinase","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pyruvate-metabolism","display_name":"pyruvate metabolism","score":0.843999981880188},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9980000257492065},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sterol-content","display_name":"sterol content","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fungal-virulence","display_name":"fungal virulence","score":0.6930000185966492},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5858959555625916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5614801645278931},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5453545451164246},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.5375667810440063},{"id":"https://openalex.org/C2779347548","wikidata":"https://www.wikidata.org/wiki/Q5161043","display_name":"Conidiation","level":4,"score":0.47971218824386597},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4596516489982605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35222095251083374},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25426530838012695},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18892401456832886},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15150198340415955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D025301","descriptor_name":"Hyphae","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.ppat.1005133","doi":"https://doi.org/10.1371/journal.ppat.1005133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005133","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005133&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3541182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552728","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4552728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:26317337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26317337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:922a28b40ff54410acbd0036f4597120","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/922a28b40ff54410acbd0036f4597120","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 11, Iss 8, p e1005133 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1527128","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Mitochondrial_Activity_and_Cyr1_Are_Key_Regulators_of_Ras1_Activation_of_C_albicans_Virulence_Pathways/1527128","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1005133","doi":"https://doi.org/10.1371/journal.ppat.1005133","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1005133","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005133&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6981840230","display_name":"Molecular and Cellular Biology at Dartmouth","funder_award_id":"T32GM008704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7390158464","display_name":"Dynamics of Bacterial-Fungal Interactions in Chronic Lung Infections","funder_award_id":"R01GM108492","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000863065","display_name":"Host-Microbe Interactions","funder_award_id":"T32AI007519","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320310400","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22"},{"id":"https://openalex.org/F4320311350","display_name":"Life Sciences Research Foundation","ror":"https://ror.org/0195dxj21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1632467620.pdf","grobid_xml":"https://content.openalex.org/works/W1632467620.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1500387969","https://openalex.org/W1523693806","https://openalex.org/W1762890948","https://openalex.org/W1831912214","https://openalex.org/W1841162023","https://openalex.org/W1964616617","https://openalex.org/W1967864456","https://openalex.org/W1979027806","https://openalex.org/W1979853218","https://openalex.org/W1982775535","https://openalex.org/W1985464808","https://openalex.org/W1991471393","https://openalex.org/W1992197029","https://openalex.org/W1993122323","https://openalex.org/W1993521681","https://openalex.org/W1993727333","https://openalex.org/W1994780794","https://openalex.org/W1994999924","https://openalex.org/W1995830102","https://openalex.org/W1999340863","https://openalex.org/W2001313326","https://openalex.org/W2003822984","https://openalex.org/W2005105017","https://openalex.org/W2010335504","https://openalex.org/W2012034776","https://openalex.org/W2012508946","https://openalex.org/W2015969127","https://openalex.org/W2016507401","https://openalex.org/W2016752484","https://openalex.org/W2017407017","https://openalex.org/W2018502270","https://openalex.org/W2027727188","https://openalex.org/W2031111964","https://openalex.org/W2031464657","https://openalex.org/W2032893561","https://openalex.org/W2033190396","https://openalex.org/W2034281332","https://openalex.org/W2036699947","https://openalex.org/W2036811094","https://openalex.org/W2038417443","https://openalex.org/W2038719295","https://openalex.org/W2040362471","https://openalex.org/W2040856926","https://openalex.org/W2043717389","https://openalex.org/W2054598634","https://openalex.org/W2057583358","https://openalex.org/W2058216045","https://openalex.org/W2058268415","https://openalex.org/W2063403933","https://openalex.org/W2071921540","https://openalex.org/W2079580613","https://openalex.org/W2080026861","https://openalex.org/W2080577934","https://openalex.org/W2083961274","https://openalex.org/W2085019683","https://openalex.org/W2085341005","https://openalex.org/W2088755036","https://openalex.org/W2089632133","https://openalex.org/W2093982944","https://openalex.org/W2096110497","https://openalex.org/W2104253511","https://openalex.org/W2104767186","https://openalex.org/W2107835138","https://openalex.org/W2110919024","https://openalex.org/W2112026166","https://openalex.org/W2114725487","https://openalex.org/W2116429296","https://openalex.org/W2117262980","https://openalex.org/W2119507799","https://openalex.org/W2121045940","https://openalex.org/W2121730836","https://openalex.org/W2124588380","https://openalex.org/W2125164964","https://openalex.org/W2127142654","https://openalex.org/W2132092226","https://openalex.org/W2133183053","https://openalex.org/W2141142060","https://openalex.org/W2142554739","https://openalex.org/W2143712580","https://openalex.org/W2144035662","https://openalex.org/W2146115175","https://openalex.org/W2152255355","https://openalex.org/W2157017251","https://openalex.org/W2157931918","https://openalex.org/W2160615487","https://openalex.org/W2162566576","https://openalex.org/W2163110564","https://openalex.org/W2167580004","https://openalex.org/W2171089401","https://openalex.org/W2582743722","https://openalex.org/W4232741726","https://openalex.org/W4235294385"],"related_works":["https://openalex.org/W7097013894","https://openalex.org/W2104253511","https://openalex.org/W2150023843","https://openalex.org/W4292477541","https://openalex.org/W4401443617","https://openalex.org/W2896091232","https://openalex.org/W2162566576","https://openalex.org/W7112603271","https://openalex.org/W2950010168","https://openalex.org/W1885405831"],"abstract_inverted_index":{"Candida":[0,93],"albicans":[1,48,85],"is":[2,24,42,65,193],"both":[3],"a":[4,9,43,99,185,236,254,277],"major":[5,44],"fungal":[6],"pathogen":[7],"and":[8,28,55,81,86,104,125,139,155,167,178,259,265,285],"member":[10],"of":[11,46,123,142,152,165,191,224,231,244,295],"the":[12,36,156,189,212,222,242,293],"commensal":[13],"human":[14],"microflora.":[15],"The":[16,39,204],"morphological":[17],"switch":[18],"from":[19],"yeast":[20,116],"to":[21,34,228,249,275,281,291],"hyphal":[22,63],"growth":[23,64],"associated":[25],"with":[26,96,145,272],"disease":[27],"many":[29],"environmental":[30,284],"factors":[31],"are":[32],"known":[33],"influence":[35,267],"yeast-to-hyphae":[37],"switch.":[38],"Ras1-Cyr1-PKA":[40],"pathway":[41],"regulator":[45],"C.":[47,84],"morphogenesis":[49],"as":[50,52,115],"well":[51],"biofilm":[53],"formation":[54],"white-opaque":[56],"switching.":[57],"Previous":[58],"studies":[59],"have":[60],"shown":[61],"that":[62,74],"strongly":[66,77],"repressed":[67],"by":[68,130,195],"mitochondrial":[69,75,251],"inhibitors.":[70,132],"Here,":[71],"we":[72],"show":[73],"inhibitors":[76,148],"decreased":[78,135,168,250],"Ras1":[79,126,192,205,213,238,258,266],"GTP-binding":[80,127],"activity":[82,103,252],"in":[83,91,117,160,187,198,226,241,247,262],"similar":[87],"effects":[88],"were":[89],"observed":[90],"other":[92,269],"species.":[94],"Consistent":[95],"there":[97],"being":[98],"connection":[100],"between":[101],"respiratory":[102,131,147],"GTP-Ras1":[105],"binding,":[106],"mutants":[107],"lacking":[108],"complex":[109,112,279],"I":[110],"or":[111],"IV":[113],"grew":[114],"hypha-inducing":[118],"conditions,":[119],"had":[120],"lower":[121],"levels":[122,197],"GTP-Ras1,":[124],"was":[128,219],"unaffected":[129],"Mitochondria-perturbing":[133],"agents":[134],"intracellular":[136,286],"ATP":[137,196,232],"concentrations":[138],"metabolomics":[140],"analyses":[141],"cells":[143],"grown":[144],"different":[146,283],"found":[149],"consistent":[150],"perturbation":[151],"pyruvate":[153],"metabolism":[154],"TCA":[157],"cycle,":[158],"changes":[159],"redox":[161],"state,":[162],"increased":[163,173],"catabolism":[164],"lipids,":[166],"sterol":[169],"content":[170],"which":[171,188,263],"suggested":[172],"AMP":[174,200],"kinase":[175,201],"activity.":[176],"Biochemical":[177],"genetic":[179],"experiments":[180],"provide":[181],"strong":[182],"evidence":[183],"for":[184,221,257],"model":[186,256],"activation":[190],"controlled":[194],"an":[199],"independent":[202],"manner.":[203],"GTPase":[206],"activating":[207],"protein,":[208],"Ira2,":[209,273],"but":[210],"not":[211],"guanine":[214],"nucleotide":[215],"exchange":[216],"factor,":[217],"Cdc25,":[218],"required":[220],"reduction":[223,230],"Ras1-GTP":[225,245],"response":[227,248],"inhibitor-mediated":[229],"levels.":[233],"Furthermore,":[234],"Cyr1,":[235],"well-characterized":[237],"effector,":[239],"participated":[240],"control":[243],"binding":[246],"suggesting":[253],"revised":[255],"Cyr1":[260,264],"signaling":[261],"each":[268],"and,":[270],"together":[271],"seem":[274],"form":[276],"master-regulatory":[278],"necessary":[280],"integrate":[282],"signals,":[287],"including":[288],"metabolic":[289],"status,":[290],"decide":[292],"fate":[294],"cellular":[296],"morphology.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}