{"id":"https://openalex.org/W16322264","doi":null,"title":"The induction of anagen hair growth in telogen mouse skin by cyclosporine A administration.","display_name":"The induction of anagen hair growth in telogen mouse skin by cyclosporine A administration.","publication_year":1989,"publication_date":"1989-03-01","ids":{"openalex":"https://openalex.org/W16322264","mag":"16322264","pmid":"https://pubmed.ncbi.nlm.nih.gov/2927078"},"language":"en","primary_location":{"id":"pmid:2927078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2927078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082322510","display_name":"Ralf Paus","orcid":"https://orcid.org/0000-0002-3492-9358","observed_orcids":["https://orcid.org/0000-0002-3492-9358"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Paus","raw_affiliation_strings":["Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109925056","display_name":"Kurt S. Stenn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K S Stenn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019032811","display_name":"Richard Edward Link","orcid":"https://orcid.org/0000-0001-9019-7633","observed_orcids":["https://orcid.org/0000-0001-9019-7633"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Link","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0504,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.97025723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"60","issue":"3","first_page":"365","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.996999979019165},{"id":"https://openalex.org/keywords/anagen-induction","display_name":"anagen induction","score":0.9430000185966492},{"id":"https://openalex.org/keywords/telogen","display_name":"telogen","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hair-follicle-growth","display_name":"hair follicle growth","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hypertrichosis","display_name":"hypertrichosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immunosuppressant-adverse-effects","display_name":"immunosuppressive drug adverse effects","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hair-cycle","display_name":"hair cycle","score":0.7179999947547913},{"id":"https://openalex.org/keywords/keratinization","display_name":"keratinization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5849999785423279},{"id":"https://openalex.org/keywords/mouse-skin","display_name":"mouse skin","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2775876775","wikidata":"https://www.wikidata.org/wiki/Q595010","display_name":"Hypertrichosis","level":2,"score":0.8079074025154114},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.7990559339523315},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6436291933059692},{"id":"https://openalex.org/C3020618081","wikidata":"https://www.wikidata.org/wiki/Q5937811","display_name":"Hair growth","level":2,"score":0.5955380201339722},{"id":"https://openalex.org/C2991961867","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair cycle","level":3,"score":0.5689495801925659},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5641160607337952},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5488137602806091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4902782738208771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4697430729866028},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.44116532802581787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3745819926261902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3710602819919586},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.19659742712974548},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17776834964752197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06383177638053894}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003524","descriptor_name":"Cyclosporins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2927078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2927078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:16322264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2927078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084005375","https://openalex.org/W2065545597","https://openalex.org/W2039000256","https://openalex.org/W2026529903","https://openalex.org/W2125500104","https://openalex.org/W2157046997","https://openalex.org/W42551788","https://openalex.org/W2134913908","https://openalex.org/W2385531199","https://openalex.org/W2023815057"],"abstract_inverted_index":{"One":[0],"clinical":[1],"complication":[2],"of":[3,12,44,51,76,113,125,137,153,164],"immunosuppressive":[4],"cyclosporine":[5],"A":[6],"(CsA)":[7],"therapy":[8],"is":[9,116],"the":[10,27,41,45,74,111,119,140,150,162],"stimulation":[11],"hair":[13,32,42,77,105,157],"growth.":[14],"Since":[15],"few":[16],"pharmacologic":[17],"agents":[18],"cause":[19],"hypertrichosis,":[20],"CsA":[21,39,62,84,138,154],"appears":[22],"particularly":[23],"interesting":[24],"for":[25],"investigating":[26],"mechanisms":[28,152,163],"which":[29,72],"control":[30],"normal":[31,95,104,165],"formation.":[33],"Previous":[34],"investigators":[35],"have":[36,59],"shown":[37],"that":[38,61,83,110,128,148],"affects":[40],"growth":[43,92,158],"laboratory":[46,96],"rat,":[47],"several":[48],"genetic":[49],"variants":[50],"mice,":[52],"as":[53,55],"well":[54],"humans,":[56],"and":[57,123,127,142],"they":[58],"concluded":[60],"influences":[63],"keratinization":[64],"predominantly.":[65],"Using":[66],"a":[67,103,134],"well-defined":[68],"in":[69,94],"vivo":[70],"assay":[71],"measures":[73],"induction":[75,115],"follicle":[78],"growth,":[79],"we":[80],"report":[81],"here":[82],"induces":[85],"resting":[86],"(telogen)":[87],"follicles":[88],"to":[89],"enter":[90],"active":[91],"(anagen)":[93],"mice":[97],"(C57":[98],"B1-6),":[99],"i.e.,":[100],"animals":[101],"with":[102],"cycle.":[106],"The":[107],"experiments":[108],"indicate":[109],"rate":[112],"anagen":[114,166],"dependent":[117],"on":[118,139,156],"dose,":[120],"time":[121],"course,":[122],"method":[124],"administration":[126],"it":[129],"may":[130],"be":[131],"mediated":[132],"via":[133],"direct":[135],"action":[136,155],"skin":[141],"its":[143],"appendages.":[144],"These":[145],"studies":[146],"suggest":[147],"understanding":[149],"molecular":[151],"will":[159],"help":[160],"elucidate":[161],"induction.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}