{"id":"https://openalex.org/W1632191","doi":null,"title":"\u8840\u7ba1\u7d27\u5f20\u7d20II I\u578b\u53d7\u4f53\u963b\u65ad\u5242\u6291\u5236\u5927\u9f20\u7f3a\u8840\u2014\u518d\u704c\u6ce8\u6a21\u578b\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1","display_name":"\u8840\u7ba1\u7d27\u5f20\u7d20II I\u578b\u53d7\u4f53\u963b\u65ad\u5242\u6291\u5236\u5927\u9f20\u7f3a\u8840\u2014\u518d\u704c\u6ce8\u6a21\u578b\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1632191","mag":"1632191"},"language":"zh-cn","primary_location":{"id":"mag:1632191","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92767X/200102/4989152.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541228","display_name":"\u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058964790","display_name":"\u9f50\u4e3d\u5f64","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u9f50\u4e3d\u5f64","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023316029","display_name":"\u5f20\u94a7\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u94a7\u534e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004268014","display_name":"\u674e\u5927\u5143","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u5927\u5143","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102425387","display_name":"Zhou Airu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5468\u7231\u5112","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00031293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"2","first_page":"118","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9509999752044678},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-artery-ligation","display_name":"coronary artery ligation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27861642837524414}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1632191","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92767X/200102/4989152.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541228","display_name":"\u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5fc3\u8840\u7ba1\u75c5\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W812337076","https://openalex.org/W2381168332","https://openalex.org/W1146257815","https://openalex.org/W1503178118","https://openalex.org/W3031346692","https://openalex.org/W2340737735","https://openalex.org/W2170143689","https://openalex.org/W1018455620","https://openalex.org/W1013361891","https://openalex.org/W868322465"],"abstract_inverted_index":{"\u76ee\u7684\u89c2\u5bdf\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u2160\u578b\u53d7\u4f53\u963b\u65ad\u5242losartan\u5bf9\u5927\u9f20\u5fc3\u808c\u7f3a\u8840-\u518d\u704c\u6ce8\u6a21\u578b\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u53ca\u51cb\u4ea1\u76f8\u5173\u86cb\u767dP53\u548cBcl-2\u8868\u8fbe\u7684\u5f71\u54cd\u3002\u65b9\u6cd5":[0],"Wistar\u5927\u9f20\u968f\u673a\u5206\u4e3a\u4e09\u7ec4:":[1],"(1)\u5047\u624b\u672f\u7ec4(5\u53ea)\uff1b(2)\u7f3a\u8840-\u518d\u704c\u6ce8\u7ec4(6\u53ea)\uff1a\u7ed3\u624e\u5de6\u51a0\u72b6\u52a8\u810945":[2],"min\uff0c\u518d\u704c\u6ce84":[3],"h\uff1b(3)losartan\u7ec4(6\u53ea)\uff1a\u7f3a\u8840\u524d15":[4],"min\u548c\u518d\u704c\u6ce81":[5],"h\u5206\u522b\u9759\u8109\u6ce8\u5c04losartan":[6],"10":[7],"mg/kg\u3002\u91c7\u7528TUNEL\u548cDNA\u7535\u6cf3\u65b9\u6cd5\u68c0\u6d4b\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff0c\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u65b9\u6cd5\u68c0\u6d4b\u5fc3\u808c\u7ec4\u7ec7P53\u548cBcl-2\u86cb\u767d\u8868\u8fbe\u3002\u7ed3\u679c\u7f3a\u8840-\u518d\u704c\u6ce8\u7ec4\u51cb\u4ea1\u5fc3\u808c\u7ec6\u80de\u6570\u91cf\u4e3a(28.4\u00b11.4)\uff05\uff0closartan\u7ec4\u51cb\u4ea1\u5fc3\u808c\u7ec6\u80de\u6570\u91cf\u663e\u8457\u51cf\u5c11(10.3\u00b12.1)\uff05\uff0cP\uff1c0.01\u3002\u7f3a\u8840-\u518d\u704c\u6ce8\u7ec4\u5fc3\u808cP53\u8868\u8fbe\u589e\u52a0\u3002losartan\u6291\u5236P53\u7684\u8868\u8fbe\uff0c\u589e\u52a0Bcl-2\u8868\u8fbe\u3002\u7ed3\u8bba\u7f3a\u8840-\u518d\u704c\u6ce8\u8fc7\u7a0b\u4e2d\u5927\u9f20\u5fc3\u808c\u7ec6\u80de\u53ef\u4ee5\u53d1\u751f\u51cb\u4ea1\uff0c\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u2160\u578b\u53d7\u4f53\u963b\u65ad\u5242\u53ef\u51cf\u5c11\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u7684\u6570\u91cf\uff0c\u6291\u5236\u5fc3\u808cP53\u7684\u8868\u8fbe\u3001\u4fc3\u8fdbBcl-2\u7684\u8868\u8fbe\u3002":[8]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
