{"id":"https://openalex.org/W162955091","doi":"https://doi.org/10.1007/978-1-4612-0411-4_27","title":"Transformation in vitro of Human Uroepithelial Cells","display_name":"Transformation in vitro of Human Uroepithelial Cells","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W162955091","doi":"https://doi.org/10.1007/978-1-4612-0411-4_27","mag":"162955091"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-0411-4_27","doi":"https://doi.org/10.1007/978-1-4612-0411-4_27","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0411-4_27","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplastic Transformation in Human Cell Culture","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2484655577","display_name":"Neoplastic Transformation in Human Cell Culture"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109874549","display_name":"Catherine A. Reznikoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. A. Reznikoff","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365848","display_name":"Chinghai H. Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Kao","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055266582","display_name":"E A Bookland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. A. Bookland","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052858229","display_name":"Aloysius John Klingelhutz","orcid":"https://orcid.org/0000-0003-4258-5046","observed_orcids":["https://orcid.org/0000-0003-4258-5046"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. J. Klingelhutz","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047895214","display_name":"Carol I. Pratt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. I. Pratt","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036530413","display_name":"Shi-Q. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Q. Wu","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109884621","display_name":"Kennedy W. Gilchrist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. W. Gilchrist","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108198191","display_name":"Santhanam Swaminathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Swaminathan","raw_affiliation_strings":["Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology and Clinical Cancer Center, University of Wisconsin, Madison, Wisconsin, 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":4.0593,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92788681,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"269","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelial-cells","display_name":"urothelial cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/in-vitro-transformation","display_name":"in vitro transformation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/sv40-t-antigen","display_name":"SV40 T antigen","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/4-aminobiphenyl","display_name":"4-aminobiphenyl","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bladder-carcinogens","display_name":"bladder carcinogens","score":0.6650000214576721},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.6150000095367432},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7274694442749023},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6114916205406189},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6110261678695679},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.5826389789581299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.566471517086029},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.5560509562492371},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5195741653442383},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48891058564186096},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4888615012168884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44990453124046326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3307512700557709},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32317212224006653},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.24809148907661438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20768886804580688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20716163516044617}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-0411-4_27","doi":"https://doi.org/10.1007/978-1-4612-0411-4_27","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0411-4_27","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplastic Transformation in Human Cell Culture","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1481453709","https://openalex.org/W1512405920","https://openalex.org/W1527185783","https://openalex.org/W1579210380","https://openalex.org/W1592937239","https://openalex.org/W1685865647","https://openalex.org/W1969608696","https://openalex.org/W1974932491","https://openalex.org/W1980890490","https://openalex.org/W1984281240","https://openalex.org/W1998562271","https://openalex.org/W2001258296","https://openalex.org/W2024107234","https://openalex.org/W2061805562","https://openalex.org/W2061963998","https://openalex.org/W2084139000","https://openalex.org/W2117646911","https://openalex.org/W2129558050","https://openalex.org/W2132010690","https://openalex.org/W2140566800","https://openalex.org/W2282729549","https://openalex.org/W2416337753","https://openalex.org/W2421538998","https://openalex.org/W3134722214","https://openalex.org/W4239751613"],"related_works":["https://openalex.org/W2132010690","https://openalex.org/W2140566800","https://openalex.org/W2402051617","https://openalex.org/W2023115042","https://openalex.org/W2093231955","https://openalex.org/W7099423244","https://openalex.org/W2731079186","https://openalex.org/W2034567612","https://openalex.org/W2105759508","https://openalex.org/W7099087834"],"abstract_inverted_index":{"Normal":[0],"human":[1,29,45],"uroepithelial":[2],"cells":[3],"can":[4],"now":[5],"be":[6,88],"routinely":[7],"cultured":[8],"in":[9,52,65],"vitro":[10,53],",":[11],"immortalized":[12],"by":[13,56,73,77],"SV40":[14],"T":[15],"antigen":[16],"oncoprotein":[17],"gene,":[18],"and":[19,34,37,75,84],"tumorigenically":[20],"transformed":[21],"after":[22],"exposure":[23],"to":[24,40],"oncogenic":[25],"agents":[26],"including":[27],"the":[28,78,85,91],"bladder":[30,46,67],"carcinogen,":[31],"4-aminobiphenyl":[32],"(ABP)":[33],"its":[35],"metabolites":[36],"mutant":[38],"EJ/ras":[39],"carcinoma":[41],"phenotypes":[42],"that":[43,59],"resemble":[44],"cancers.":[47,68],"Neoplastic":[48],"transformation":[49],"of":[50],"HUC":[51],"is":[54,82],"accompanied":[55],"chromosome":[57],"changes":[58,63],"recapitulate":[60],"many":[61],"cytogenetic":[62],"reported":[64],"clinical":[66],"These":[69],"keywords":[70,86],"were":[71],"added":[72],"machine":[74],"not":[76],"authors.":[79],"This":[80],"process":[81],"experimental":[83],"may":[87],"updated":[89],"as":[90],"learning":[92],"algorithm":[93],"improves.":[94]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}