{"id":"https://openalex.org/W1629389488","doi":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","title":"Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty","display_name":"Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty","publication_year":2010,"publication_date":"2010-05-27","ids":{"openalex":"https://openalex.org/W1629389488","doi":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","mag":"1629389488","pmid":"https://pubmed.ncbi.nlm.nih.gov/20722847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3014265"},"language":"en","primary_location":{"id":"doi:10.1111/j.1532-5415.2010.02865.x","doi":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3014265/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027947710","display_name":"Rose Anne Kenny","orcid":"https://orcid.org/0000-0002-9336-8124","observed_orcids":["https://orcid.org/0000-0002-9336-8124"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Kenny","raw_affiliation_strings":["Center on Aging, MC-5215, University of Connecticut Health Center, Farmington, CT 06030, USA. kenny@uchc.edu","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, MC-5215, University of Connecticut Health Center, Farmington, CT 06030, USA. kenny@uchc.edu","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032115933","display_name":"Alison Kleppinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Kleppinger","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051485444","display_name":"Kristen Annis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Annis","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072551606","display_name":"M. Rathier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Rathier","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce Browner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Browner","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103528781","display_name":"James O. Judge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James O. Judge","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109849417","display_name":"Daniel McGee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel McGee","raw_affiliation_strings":["From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","\u00a7Evercare Connecticut, Hartford, Connecticut","\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","\u2225Department of Statistics, Florida State University, Tallahassee, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the * Center on Aging, \u2020 Veterans Affairs Connecticut Healthcare System, Newington, Connecticut; \u2021 New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut; \u00a7 Evercare Connecticut, Hartford, Connecticut; and \u2225 Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I75929689"]},{"raw_affiliation_string":"From the\n*Center on Aging, \u2020Veterans Affairs Connecticut Healthcare System, Newington, Connecticut","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"\u00a7Evercare Connecticut, Hartford, Connecticut","institution_ids":[]},{"raw_affiliation_string":"\u2021New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"\u2225Department of Statistics, Florida State University, Tallahassee, Florida","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":12.6206,"has_fulltext":false,"cited_by_count":253,"citation_normalized_percentile":{"value":0.99187276,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"58","issue":"6","first_page":"1134","last_page":"1143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testosterone-replacement-therapy","display_name":"testosterone replacement therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/transdermal-testosterone","display_name":"transdermal testosterone","score":0.9599999785423279},{"id":"https://openalex.org/keywords/testosterone-deficiency","display_name":"androgen deficiency","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hypogonadism","display_name":"hypogonadism","score":0.8270000219345093},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7720000147819519},{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/physical-frailty","display_name":"physical frailty","score":0.8349999785423279},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.921999990940094},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.8169999718666077},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.6600000262260437},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.7559999823570251},{"id":"https://openalex.org/keywords/fracture-history","display_name":"fracture history","score":0.625},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.652999997138977},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8949135541915894},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7971698641777039},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.6914668083190918},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6460006237030029},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.6080923676490784},{"id":"https://openalex.org/C2775854910","wikidata":"https://www.wikidata.org/wiki/Q4844892","display_name":"Femoral neck","level":3,"score":0.583807110786438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5762364864349365},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.569599449634552},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5054376125335693},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.49109435081481934},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48658549785614014},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.43719029426574707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1532-5415.2010.02865.x","doi":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1532-5415.2010.02865.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:20722847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20722847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3014265","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3014265/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Geriatr Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3014265","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3014265/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Geriatr Soc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2409576744","display_name":null,"funder_award_id":"R01 AG1","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2655221040","display_name":"General Clinical Research Center","funder_award_id":"M01RR006192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3831504750","display_name":"TESTOSTERONE FOR PREVENTION OF FRACTURE IN MEN","funder_award_id":"R01AG018887","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4452414121","display_name":"CLAUDE PEPPER OLDER AMERICANS INDEPENDENCE CENTER","funder_award_id":"P60AG013631","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1513674708","https://openalex.org/W1562992882","https://openalex.org/W1915611504","https://openalex.org/W1971454445","https://openalex.org/W1974704788","https://openalex.org/W1980179699","https://openalex.org/W1989458934","https://openalex.org/W1992811319","https://openalex.org/W2005904869","https://openalex.org/W2016492979","https://openalex.org/W2036978149","https://openalex.org/W2040631444","https://openalex.org/W2051191691","https://openalex.org/W2075118988","https://openalex.org/W2093255726","https://openalex.org/W2095471601","https://openalex.org/W2096487978","https://openalex.org/W2102076625","https://openalex.org/W2105071743","https://openalex.org/W2116516133","https://openalex.org/W2116827517","https://openalex.org/W2127219068","https://openalex.org/W2133467178","https://openalex.org/W2135959338","https://openalex.org/W2142563833","https://openalex.org/W2149100552","https://openalex.org/W2150101787","https://openalex.org/W2152152253","https://openalex.org/W2156908503","https://openalex.org/W2161417745","https://openalex.org/W2164059021","https://openalex.org/W2185952775","https://openalex.org/W2277044869","https://openalex.org/W2496143106","https://openalex.org/W2588746827","https://openalex.org/W3036378166","https://openalex.org/W6645458349","https://openalex.org/W6723482101"],"related_works":["https://openalex.org/W7218142900","https://openalex.org/W2127219068","https://openalex.org/W2412756456","https://openalex.org/W2154398226","https://openalex.org/W2056150258","https://openalex.org/W2112008927","https://openalex.org/W1992811319","https://openalex.org/W2128339742","https://openalex.org/W7151848093","https://openalex.org/W1565549175"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"investigate":[2],"the":[3,159,168,174,182,199],"effects":[4],"of":[5,44,62,85,136],"testosterone":[6,63,146,164,200,222,225],"supplementation":[7],"on":[8,163],"bone,":[9],"body":[10,91,232],"composition,":[11,233],"muscle,":[12],"physical":[13,101,208,244],"function,":[14],"and":[15,55,77,79,89,103,113,144,154,171,178,192,227,239],"safety":[16,104,215],"in":[17,158,189,195,198,205,214,231,236,243],"older":[18],"men.":[19],"DESIGN:":[20],"Double-blind,":[21],"randomized,":[22],"placebo-controlled":[23],"trial.":[24],"SETTING:":[25],"A":[26],"major":[27],"medical":[28],"institution.":[29],"PARTICIPANTS:":[30],"One":[31],"hundred":[32],"thirty-one":[33],"men":[34,108,220],"(mean":[35,119],"age":[36],"77.1":[37],"+/-":[38],"7.6)":[39],"with":[40,134],"low":[41],"testosterone,":[42],"history":[43],"fracture,":[45],"or":[46,64,140,207],"bone":[47,97],"mineral":[48],"density":[49],"(BMD)":[50],"T-score":[51],"less":[52],"than":[53],"-2.0":[54],"frailty.":[56],"INTERVENTION:":[57],"Participants":[58],"received":[59,72],"5":[60],"mg/d":[61,75],"placebo":[65],"for":[66,125],"12":[67,111,149],"to":[68],"24":[69],"months;":[70,121],"all":[71],"calcium":[73],"(1500":[74],"diet":[76],"supplement)":[78],"cholecalciferol":[80],"(1,000":[81],"IU/d).":[82],"MEASUREMENTS:":[83],"BMD":[84,162],"hip,":[86],"lumbar":[87,175],"spine,":[88],"mid-radius;":[90],"composition;":[92],"sex":[93],"hormones,":[94],"calcium-regulating":[95],"hormones;":[96],"turnover":[98],"markers;":[99],"strength;":[100],"performance;":[102],"parameters.":[105,216],"RESULTS:":[106],"Ninety-nine":[107],"(75.6%)":[109],"completed":[110,116,128],"months,":[112],"62":[114,126],"(47.3%)":[115],"end":[117],"therapy":[118],"23":[120],"range":[122],"16-24":[123],"months":[124,150],"who":[127],"therapy).":[129],"Study":[130],"adherence":[131],"was":[132,186],"54%,":[133],"40%":[135],"subjects":[137],"maintaining":[138],"70%":[139],"greater":[141],"adherence.":[142],"Testosterone":[143],"bioavailable":[145],"levels":[147,226],"at":[148,167,173,181],"were":[151,211],"583":[152],"ng/dL":[153],"157":[155],"ng/dL,":[156],"respectively,":[157],"treatment":[160],"group.":[161],"increased":[165,224],"1.4%":[166],"femoral":[169],"neck":[170],"3.2%":[172],"spine":[176],"(P=.005)":[177],"decreased":[179],"1.3%":[180],"mid-radius":[183],"(P<.001).":[184],"There":[185,210],"an":[187],"increase":[188],"lean":[190],"mass":[191,197],"a":[193],"decrease":[194],"fat":[196],"group":[201],"but":[202],"no":[203,212,240],"differences":[204,213],"strength":[206],"performance.":[209],"CONCLUSION:":[217],"Older,":[218],"frail":[219],"receiving":[221],"replacement":[223],"had":[228],"favorable":[229],"changes":[230,235,242],"modest":[234],"axial":[237],"BMD,":[238],"substantial":[241],"function.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}