{"id":"https://openalex.org/W162889216","doi":null,"title":"Methadone therapy for opioid dependence.","display_name":"Methadone therapy for opioid dependence.","publication_year":2001,"publication_date":"2001-06-15","ids":{"openalex":"https://openalex.org/W162889216","mag":"162889216","pmid":"https://pubmed.ncbi.nlm.nih.gov/11430455"},"language":"en","primary_location":{"id":"pmid:11430455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11430455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American family physician","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051731809","display_name":"L L Krambeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L L Krambeer","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City 66160-7341, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City 66160-7341, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064519417","display_name":"William McKnelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W von McKnelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017117577","display_name":"William F. Gabrielli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W F Gabrielli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111636933","display_name":"Elizabeth C. Penick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C Penick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7863,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.85067279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"12","first_page":"2404","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methadone-maintenance-treatment","display_name":"methadone maintenance treatment","score":0.9919999837875366},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/withdrawal-syndrome","display_name":"withdrawal syndrome","score":0.656000018119812},{"id":"https://openalex.org/keywords/opioid-craving","display_name":"opioid craving","score":0.6660000085830688},{"id":"https://openalex.org/keywords/opioid-detoxification","display_name":"opioid detoxification","score":0.550000011920929},{"id":"https://openalex.org/keywords/primary-care-coordination","display_name":"primary care coordination","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9295613765716553},{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.8241142630577087},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7085577249526978},{"id":"https://openalex.org/C2909923361","wikidata":"https://www.wikidata.org/wiki/Q2339584","display_name":"Directly Observed Therapy","level":3,"score":0.5861957669258118},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5511087775230408},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5295615792274475},{"id":"https://openalex.org/C2778903686","wikidata":"https://www.wikidata.org/wiki/Q60168","display_name":"Heroin","level":3,"score":0.51127028465271},{"id":"https://openalex.org/C2778903061","wikidata":"https://www.wikidata.org/wiki/Q17156814","display_name":"Methadone maintenance","level":3,"score":0.5041748285293579},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.49307772517204285},{"id":"https://openalex.org/C2779418921","wikidata":"https://www.wikidata.org/wiki/Q1639178","display_name":"Opioid use disorder","level":4,"score":0.48661836981773376},{"id":"https://openalex.org/C2775849661","wikidata":"https://www.wikidata.org/wiki/Q940","display_name":"Narcotic","level":2,"score":0.44963783025741577},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.44401025772094727},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.40807104110717773},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.22775688767433167},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.22152483463287354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14869177341461182},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10513579845428467},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.08582711219787598},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006040","descriptor_name":"Goals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11430455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11430455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American family physician","raw_type":"Journal Article"},{"id":"mag:162889216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11430455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1512554607","https://openalex.org/W1543439003","https://openalex.org/W1965069933","https://openalex.org/W1973849525","https://openalex.org/W1993215757","https://openalex.org/W2002091306","https://openalex.org/W2009337097","https://openalex.org/W2029891253","https://openalex.org/W2043146878","https://openalex.org/W2046457014","https://openalex.org/W2063256886","https://openalex.org/W2072922273","https://openalex.org/W2096117314","https://openalex.org/W2097145370","https://openalex.org/W2098696757","https://openalex.org/W2146707742","https://openalex.org/W2151273028","https://openalex.org/W2157107661","https://openalex.org/W2559306019"],"related_works":["https://openalex.org/W1041456650","https://openalex.org/W2010906830","https://openalex.org/W2272662893","https://openalex.org/W2220883480","https://openalex.org/W2124503010","https://openalex.org/W16489841","https://openalex.org/W2043485783","https://openalex.org/W1245393406","https://openalex.org/W2126913156","https://openalex.org/W2017950680"],"abstract_inverted_index":{"The":[0,117],"1999":[1],"Federal":[2],"regulations":[3],"extend":[4],"the":[5,50,73,81,128,131],"treatment":[6,56],"options":[7],"of":[8,61,76,84],"methadone-maintained":[9],"opioid-dependent":[10,175],"patients":[11,89,176],"from":[12],"specialized":[13],"clinics":[14],"to":[15,25,40,64,92,108,156],"office-based":[16],"opioid":[17,58,78],"therapy":[18,28,48,62,126],"(OBOT).":[19],"OBOT":[20],"allows":[21],"primary":[22],"care":[23],"physicians":[24],"coordinate":[26],"methadone":[27,85,184],"in":[29,174,181],"this":[30],"group":[31,38],"with":[32,183],"ongoing":[33],"medical":[34,113],"care.":[35],"This":[36],"patient":[37,129],"tends":[39],"be":[41,121],"poorly":[42],"understood":[43],"and":[44,54,71,114,152,159,167,177],"underserved.":[45],"Methadone":[46],"maintenance":[47,118],"is":[49,105],"most":[51],"widely":[52],"known":[53],"well-researched":[55],"for":[57,134,145],"dependency.":[59],"Goals":[60],"are":[63,90,98,170,178],"prevent":[65],"abstinence":[66],"syndrome,":[67],"reduce":[68],"narcotic":[69],"cravings":[70],"block":[72],"euphoric":[74],"effects":[75],"illicit":[77],"use.":[79],"In":[80],"first":[82],"phase":[83,119],"treatment,":[86],"appropriately":[87],"selected":[88],"tapered":[91],"adequate":[93],"steady-state":[94],"dosing.":[95],"Once":[96],"they":[97],"stabilized":[99],"on":[100],"a":[101,124],"satisfactory":[102],"dosage,":[103],"it":[104],"often":[106],"possible":[107],"address":[109],"their":[110],"other":[111,153],"chronic":[112],"psychiatric":[115],"conditions.":[116],"can":[120],"used":[122],"as":[123],"long-term":[125,163],"until":[127],"demonstrates":[130],"qualities":[132],"required":[133],"successful":[135],"detoxification.":[136],"Patients":[137],"who":[138],"abuse":[139],"narcotics":[140],"have":[141],"an":[142],"increased":[143,157],"risk":[144],"human":[146],"immunodeficiency":[147],"virus":[148],"infection,":[149],"hepatitis,":[150],"tuberculosis":[151],"conditions":[154],"contributing":[155],"morbidity":[158],"mortality.":[160],"Short-":[161],"or":[162],"pain":[164],"management":[165],"problems":[166],"surgical":[168],"needs":[169],"also":[171],"common":[172],"concerns":[173],"generally":[179],"treatable":[180],"conjunction":[182],"maintenance.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}