{"id":"https://openalex.org/W1627110571","doi":"https://doi.org/10.1038/28893","title":"Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex","display_name":"Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W1627110571","doi":"https://doi.org/10.1038/28893","mag":"1627110571","pmid":"https://pubmed.ncbi.nlm.nih.gov/9697776"},"language":"en","primary_location":{"id":"doi:10.1038/28893","doi":"https://doi.org/10.1038/28893","is_oa":false,"landing_page_url":"https://doi.org/10.1038/28893","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028683198","display_name":"Andr\u00e9 White","orcid":"https://orcid.org/0000-0002-4393-1062","observed_orcids":["https://orcid.org/0000-0002-4393-1062"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 White","raw_affiliation_strings":["Rosenstiel Basic Medical Sciences Research Center MS029, Brandeis University, Waltham, Massachusetts 02454-9110, USA","Rosenstiel Basic Medical Sciences Research Center MS029,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center MS029, Brandeis University, Waltham, Massachusetts 02454-9110, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center MS029,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaochun Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochun Ding","raw_affiliation_strings":["Rosenstiel Basic Medical Sciences Research Center MS029,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center MS029,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113655131","display_name":"Johanna C. vanderSpek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johanna C. vanderSpek","raw_affiliation_strings":["Department of Medicine, Boston University School of Medicine, Boston, 02118-2393, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Boston University School of Medicine, Boston, 02118-2393, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036639335","display_name":"John R. Murphy","orcid":"https://orcid.org/0000-0002-9360-4481","observed_orcids":["https://orcid.org/0000-0002-9360-4481"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Murphy","raw_affiliation_strings":["Department of Medicine, Boston University School of Medicine, Boston, 02118-2393, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Boston University School of Medicine, Boston, 02118-2393, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, Brandeis Univesity, Waltham, 02454-9110, Massachusetts, USA","Rosenstiel Basic Medical Sciences Research Center MS029,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, Brandeis Univesity, Waltham, 02454-9110, Massachusetts, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center MS029,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014900252"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.6438,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.97997835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"394","issue":"6692","first_page":"502","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4162999987602234,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4162999987602234,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12499","display_name":"Diphtheria, Corynebacterium, and Tetanus","score":0.32179999351501465,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10580000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diphtheria-toxin","display_name":"diphtheria toxin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/corynebacterium-diphtheriae","display_name":"Corynebacterium diphtheriae","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nickel-ii-binding","display_name":"nickel(II) binding","score":0.6570000052452087},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/protein-dna-complex","display_name":"protein-DNA complex","score":0.6660000085830688},{"id":"https://openalex.org/keywords/helix-coil-transition","display_name":"helix-coil transition","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.8619805574417114},{"id":"https://openalex.org/C33057221","wikidata":"https://www.wikidata.org/wiki/Q421580","display_name":"Diphtheria toxin","level":3,"score":0.7629960179328918},{"id":"https://openalex.org/C2781288345","wikidata":"https://www.wikidata.org/wiki/Q131649","display_name":"Corynebacterium diphtheriae","level":4,"score":0.6420474648475647},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.564596951007843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5418596267700195},{"id":"https://openalex.org/C17020691","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operator (biology)","level":5,"score":0.4417581558227539},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.41240859031677246},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32943955063819885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30884820222854614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29166072607040405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2274760603904724},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.21864625811576843},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.17236915230751038},{"id":"https://openalex.org/C2780572238","wikidata":"https://www.wikidata.org/wiki/Q134649","display_name":"Diphtheria","level":3,"score":0.11171111464500427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003353","descriptor_name":"Corynebacterium diphtheriae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004167","descriptor_name":"Diphtheria Toxin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009875","descriptor_name":"Operator Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019077","descriptor_name":"Helix-Turn-Helix Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/28893","doi":"https://doi.org/10.1038/28893","is_oa":false,"landing_page_url":"https://doi.org/10.1038/28893","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:9697776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9697776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:394:y:1998:i:6692:d:10.1038_28893","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/28893","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1599629122","https://openalex.org/W1795554247","https://openalex.org/W1969905579","https://openalex.org/W1970227811","https://openalex.org/W1975914851","https://openalex.org/W1985459186","https://openalex.org/W1986191025","https://openalex.org/W1993404146","https://openalex.org/W1996607909","https://openalex.org/W1997329250","https://openalex.org/W1998862250","https://openalex.org/W2000197629","https://openalex.org/W2001641653","https://openalex.org/W2005675760","https://openalex.org/W2013083986","https://openalex.org/W2024265765","https://openalex.org/W2028231353","https://openalex.org/W2031338911","https://openalex.org/W2032387849","https://openalex.org/W2033414089","https://openalex.org/W2049297824","https://openalex.org/W2072148144","https://openalex.org/W2075090496","https://openalex.org/W2080476827","https://openalex.org/W2087502952","https://openalex.org/W2091046397","https://openalex.org/W2116275717","https://openalex.org/W2155338010"],"related_works":["https://openalex.org/W2075090496","https://openalex.org/W2006409446","https://openalex.org/W1998862250","https://openalex.org/W2068018855","https://openalex.org/W1991152286","https://openalex.org/W2044999558","https://openalex.org/W1969905579","https://openalex.org/W1982757640","https://openalex.org/W1795554247","https://openalex.org/W1970227811"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}